Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants

Gram-Positive Pathogens

2019 • 1,038 citations

Erythromycin resistance by ribosome modification

1995 • 983 citations

Detection of erythromycin-resistant determinants by PCR

1996 • 977 citations

Cloning and Expression of the Tyrosinase Gene from Streptomyces antibioticus in Streptomyces lividans

1983 • 640 citations

Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system

1996 • 635 citations

Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification

1991 • 605 citations

Unconstrained bacterial promiscuity: the Tn916–Tn1545 family of conjugative transposons

1995 • 386 citations

Conjugative transposons: an unusual and diverse set of integrated gene transfer elements

1995 • 373 citations

Molecular cloning and functional analysis of a novel macrolide‐resistance determinant, mefA, from Streptococcus pyogenes

1996 • 363 citations

mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae

1997 • 304 citations

Insights into erythromycin action from studies of its activity as inducer of resistance

1995 • 273 citations

A Novel Erythromycin Resistance Methylase Gene ( ermTR ) in Streptococcus pyogenes

1998 • 259 citations

Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria

1991 • 221 citations

Presence ofermgene classes in Gram-positive bacteria of animal and human origin in Denmark

1999 • 216 citations

Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11

1995 • 215 citations

Nomenclature for New Tetracycline Resistance Determinants

1999 • 209 citations

Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare

1994 • 189 citations

Prevalence and Characterization of the Mechanisms of Macrolide, Lincosamide, and Streptogramin Resistance in Isolates of Streptococcus pneumoniae

1998 • 180 citations

A New Resistance Gene, linB , Conferring Resistance to Lincosamides by Nucleotidylation in Enterococcus faecium HM1025

1999 • 173 citations

Distribution of genes encoding erythromycin ribosomal methylases and an erythromycin efflux pump in epidemiologically distinct groups of staphylococci

1993 • 171 citations

A variety of Gram-positive bacteria carry mobile mef genes

1999 • 168 citations

Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis

1986 • 156 citations

Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545

1990 • 154 citations

Erythromycin Resistance Genes in Group A Streptococci in Finland

1999 • 151 citations

Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics

1992 • 147 citations

Evidence for natural gene transfer from gram-positive cocci to Escherichia coli

1988 • 135 citations

Origin and evolution of genes specifying resistance to macrolide, lincosamide and streptogramin antibiotics: data and hypotheses

1987 • 133 citations

Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145

1993 • 130 citations

Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin

1987 • 123 citations

Host range of the ermF rRNA methylase gene in bacteria of human and animal origin

1999 • 122 citations

Novel mechanism of macrolide resistance in Streptococcus pneumoniae

1996 • 121 citations

Complete nucleotide sequence and transcription of ermF, a macrolide-lincosamide-streptogramin B resistance determinant from Bacteroides fragilis

1986 • 116 citations

Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA

1997 • 112 citations

Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin

1989 • 111 citations

Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics

1993 • 109 citations

Cloning and characterization of a Bacteroides conjugal tetracycline-erythromycin resistance element by using a shuttle cosmid vector

1989 • 109 citations

Tetracycline resistance determinants in Mycobacterium and Streptomyces species

1994 • 109 citations

Nomenclature for tetracycline resistance determinants

1989 • 106 citations

Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB

1995 • 105 citations

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

1990 • 101 citations

Erythromycin-Resistant Neisseria gonorrhoeae and Oral Commensal Neisseria spp. Carry Known rRNA Methylase Genes

1999 • 100 citations

Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli

1995 • 99 citations

Detection of thesatAgene and transferability of virginiamycin resistance inEnterococcus faeciumfrom food-animals

1998 • 98 citations

Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport

1991 • 98 citations

Different Erythromycin Resistance Mechanisms in Group C and Group G Streptococci

1998 • 97 citations

Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins

1992 • 97 citations

Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli

1985 • 94 citations

A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofacienslibrary

1987 • 94 citations

Description of the Erythromycin-Producing Bacterium Arthrobacter sp. Strain NRRL B-3381 as Aeromicrobium erythreum gen. nov., sp. nov.

1991 • 93 citations

Inactivation of lincosaminide antibiotics in Staphylococcus. Identification of lincosaminide O-nucleotidyltransferases and comparison of the corresponding resistance genes.

1988 • 92 citations

Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics

1988 • 89 citations

Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae

1989 • 86 citations

Macrolide resistance

1998 • 84 citations

Homology of a transferable tetracycline resistance determinant of Clostridium difficile with Streptococcus (Enterococcus) faecalis transposon Tn916

1987 • 83 citations

Streptomyces antibioticus contains at least three oleandomycin‐resistance determinants, one of which shows similarity with proteins of the ABC‐transporter superfamily

1993 • 75 citations

Characterization of a Staphylococcal Plasmid Related to pUB110 and Carrying Two Novel Genes, vatC and vgbB , Encoding Resistance to Streptogramins A and B and Similar Antibiotics

1998 • 75 citations

A plasmid that encodes three genes for resistance to macrolide antibiotics inStaphylococcus aureus

1998 • 73 citations

Azithromycin and erythromycin resistant Neisseria gonorrhoea e following treatment with azithromycin

1997 • 71 citations

Cloning and nucleotide sequence of a carbomycin-resistance gene from Streptomyces thermotolerans

1987 • 67 citations

Cloning of tlrD, a fourth resistance gene, from the tyiosin producer, Streptomyces fradiae

1991 • 64 citations

Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus

1987 • 64 citations

Nucleotide sequence analysis of Tn4551: use of ermFS operon fusions to detect promoter activity in Bacteroides fragilis

1987 • 61 citations

Structural Alterations in the Translational Attenuator of Constitutively Expressed ermC Genes

1999 • 61 citations

Molecular cloning and characterization of two lincomycin‐resistance genes, ImrA and ImrB, from Streptomyces lincolnensls 78–11

1992 • 60 citations

Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola

1996 • 50 citations

Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus

1986 • 50 citations

Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220

1996 • 49 citations

Cloning and hybridization analysis of ermP, a macrolide-lincosamide-streptogramin B resistance determinant from Clostridium perfringens

1989 • 49 citations

The closely related ermB-ermAM genes from Clostridium perfringens, Enterococcus faecalis (pAM beta 1), and Streptococcus agalactiae (pIP501) are flanked by variants of a directly repeated sequence

1995 • 46 citations

Cloning and sequence analysis of ermQ, the predominant macrolide-lincosamide-streptogramin B resistance gene in Clostridium perfringens

1994 • 45 citations

Cloning and nucleotide sequence of themphBgene for macrolide 2′-phosphotransferase II inEscherichia coli

1996 • 43 citations

Resistance to spiramycin in Streptomyces ambofaciens, the producer organism, involves at least two different mechanisms

1993 • 41 citations

Characterization of the genetic basis of antibiotic resistance in Clostridium difficle

1994 • 41 citations

The erythromycin resistance gene from the Bacteroides conjugal transposon Tcr Emr 7853 is nearly identical to ermG from Bacillus sphaericus

1996 • 41 citations

An erythromycin-resistance gene from an erythromycin-producing strain of Arthrobacter sp

1985 • 41 citations

Plasmid-mediated pristinamycin resistance. PAC IIA: A new enzyme which modifies pristinamycin IIA.

1977 • 40 citations

Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant from Staphylococcus xylosus

1992 • 39 citations

Emergence of the M Phenotype of Erythromycin-Resistant Pneumococci in South Africa

1998 • 38 citations

The streptogramin antibiotics: update on their mechanism of action

1998 • 37 citations

23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TlrA) methyltransferase

1994 • 34 citations

Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism

1990 • 34 citations

Nucleotide sequence ofermFU, a macrolide-lincosamidestreptogramin (MLS) resistance gene encoding an RNA methylase from the conjugal element ofBacteroides fragillsV503

1991 • 31 citations

Plasmid mediated pristinamycin resistance: PH 1A, a pristinamycin 1A hydrolase.

1977 • 30 citations

Characterization of tetracycline and erythromycin resistance in Actinobacillus pleuropneumoniae

1996 • 29 citations

Section Review Anti-infectives: Recent developments in 14- and 15-membered macrolides

1995 • 29 citations

Macrolides are ideal for empiric therapy of community-acquired pneumonia in the immunocompetent host.

1997 • 29 citations

Macrolide-lincosamide resistance determinants in streptococcal species isolated from the bovine mammary gland

1994 • 28 citations

Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant fromStaphylococcus xylosus

1992 • 28 citations

Induction of ermAMR from a Clinical Strain of Enterococcus faecalis by 16-Membered-Ring Macrolide Antibiotics

1998 • 27 citations

Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida

1994 • 25 citations

Inducible Ribosomal RNA Methylation in Streptomyces lividans, Conferring Resistance to Lincomycin

1989 • 24 citations

Role of mRNA termination in regulation of ermK

1997 • 21 citations

Nucleotide sequence of the erythromycin resistance gene from theCorynebacteriumplasmid pNG2

1990 • 20 citations

Cloning of midecamycin (MLS)-resistance genes from Streptomyces mycarofacines, Streptomyces lividans and streptomyces coelicolor A3(2).

1990 • 20 citations

Mobile rRNA methylase genes coding for erythromycin resistance in Actinobacillus actinomycetemcomitans

1996 • 19 citations

A dyadic plasmid that shows MLS and PMS resistance in Staphylococcus aureus

2006 • 19 citations

Distribution of Tetracycline and Macrolide-Lincosamide-Streptogramin B Resistance Genes in Anaerobic Bacteria

1995 • 16 citations

A Mechanism of Resistance to Partial Macrolide and Streptogramin B Antibiotics in Staphylococcus aureus Clinically Isolated in Hungary.

1995 • 14 citations

Characterization of the ATPase activity of the N-terminal nucleotide binding domain of an ABC transporter involved in oleandomycin secretion byStreptomyces antibioticus

1996 • 12 citations

Nucleotide Sequence, Expression and Transcriptional Analysis of the Escherichia coli mphK Gene Encoding Macrolide-phosphotransferase K

1996 • 11 citations