6 ́,7 ́-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

1997 • 620 citations

Interaction of citrus juices with felodipine and nifedipine

1991 • 595 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Interaction between grapefruit juice and midazolam in humans*

1995 • 360 citations

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

1995 • 349 citations

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

1998 • 309 citations

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

1997 • 303 citations

In vitro inhibition of dihydropyridine oxidation and aflatoxin B₁ activation in human liver microsomes by naringenin and other flavonoids

1990 • 247 citations

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1997 • 240 citations

Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

1993 • 230 citations

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.

1997 • 221 citations

Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation

1996 • 221 citations

Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.

1996 • 215 citations

Effect of grapefruit juice on blood cyclosporin concentration

1995 • 205 citations

Effect of quercetin on hoechst 33342 transport by purified and reconstituted p-glycoprotein

1997 • 193 citations

Specific CYP3 A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

1997 • 187 citations

Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay

1996 • 185 citations

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram*

1996 • 183 citations

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.

1992 • 177 citations

Effects of grapefruit juice ingestion - pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men

1997 • 162 citations

Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen.

1997 • 142 citations

Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice

1995 • 140 citations

Trough concentrations of cyclosporine in blood following administration with grapefruit juice

1993 • 105 citations

Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice

1993 • 101 citations

Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice

1996 • 98 citations

Ketoconazole Effectively Reverses Multidrug Resistance in Highly Resistant KB Cells

1994 • 85 citations

Grapefruit juice—terfenadine single-dose interaction: Magnitude, mechanism, and relevance*

1997 • 68 citations

Microfluorometric Evaluation of Calcein Acetoxymethyl Ester as a Probe for P-Glycoprotein-Mediated Resistance: Effects of Cyclosporin A and Its Nonimmunosuppressive Analogue SDZ PSC 833

1994 • 57 citations

Mechanism-Based Inactivation of Hepatic Ethoxyresorufin O-Dealkylation Activity by Naturally Occurring Coumarins

1996 • 51 citations

Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats.

1986 • 42 citations

Kinetic parameters for reversal of the multidrug pump as measured for drug accumulation and cell killing

1996 • 28 citations

Effect of erythromycin and tumour necrosis factor on the drug resistance of multidrug‐resistant cells: Reversal of drug resistance by erythromycin

1989 • 21 citations

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