Increased apoptosis of bone marrow pre-B cells in old mice associated with their low number

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Cell Cycle Control

1995 • 259 citations

Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta.

1989 • 229 citations

The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

1991 • 222 citations

Interleukin 7 production and function in stromal cell-dependent B cell development.

1989 • 221 citations

Effect of age on humoral immunity, selection of the B‐cell repertoire and B‐cell development

1997 • 186 citations

B cells are generated throughout life in humans.

1996 • 178 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.

1990 • 158 citations

Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors.

1997 • 133 citations

Stage-specific alterations in murine B lymphopoiesis with age

1996 • 128 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34.

1995 • 99 citations

B cell precursors are decreased in senescent mice, but retain normal mitotic activity in vivo and in vitro

1991 • 89 citations

Age-related changes in the capability of the bone marrow to generate B cells.

1988 • 88 citations

Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells

1993 • 74 citations

Activation of src family kinases in human pre-B cells by IL-7.

1994 • 71 citations

Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells.

1993 • 61 citations

Clonal expansions of B lymphocytes in old mice.

1997 • 56 citations

How B‐Precursor Cells are Driven to Cycle

1994 • 49 citations

Cell cycle control of c-kit+IL-7R+ B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium.

1995 • 41 citations

Identification of a novel low-affinity receptor for human interleukin-7

1992 • 37 citations

Age-related changes in production of interleukin-7 (IL-7) by murine long-term bone marrow cultures (LTBMC)

1993 • 23 citations

Autoantibodies inhibit interleukin-7-mediated proliferation and are associated with the age-dependent loss of pre-B cells in autoimmune New Zealand Black Mice

1996 • 15 citations