Drug Discovery in Psychiatric Illness: Mining for Gold

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

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Introduction to Data Mining

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Dopamine, learning and motivation

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Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

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Kaplan & Sadock's Comprehensive Textbook of Psychiatry

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The NIMH-MATRICS Consensus Statement on Negative Symptoms

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

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Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

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Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

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Drug target validation and identification of secondary drug target effects using DNA microarrays

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Effects of Ketamine in Normal and Schizophrenic Volunteers

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Systematic discovery of multicomponent therapeutics

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Systems biology in drug discovery

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The neuropharmacological basis of reward

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Ketamine activates psychosis and alters limbic blood flow in schizophrenia

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Preclinical Evaluation of Pharmacotherapies for Treatment of Cocaine and Opioid Abuse Using Drug Self-Administration Procedures

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The Maudsley Reactive and Nonreactive strains of rats: A survey

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Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

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Chemical combination effects predict connectivity in biological systems

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Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade

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How can drug discovery for psychiatric disorders be improved?

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NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders

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The impact of systems approaches on biological problems in drug discovery

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The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities

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Rescuing drug discovery: in vivo systems pathology and systems pharmacology

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Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement

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The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?

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Treatment of Schizophrenia Negative Symptoms: Future Prospects

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Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

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Statistical discrimination of natural modes of motion in rat exploratory behavior

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The role of human drug self-administration procedures in the development of medications

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New replicable anxiety-related measures of wall vs. center behavior of mice in the open field

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Animal Models in Psychiatry

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Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

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Genotype–environment interactions in mouse behavior: A way out of the problem

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An integrative biology approach for analysis of drug action in models of human vascular inflammation

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Rapid Structure-Activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-Based Models

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SEE locomotor behavior test discriminates C57BL/6J and DBA/2J mouse inbred strains across laboratories and protocol conditions.

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A pathophysiological paradigm for the therapy of psychiatric disease

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Application of Genomic Biomarkers to Predict Increased Lung Tumor Incidence in 2-Year Rodent Cancer Bioassays

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Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior

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A Comparison of Transcriptomic and Metabonomic Technologies for Identifying Biomarkers Predictive of Two-Year Rodent Cancer Bioassays

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Concept of schizophrenia

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Estimating wall guidance and attraction in mouse free locomotor behavior

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Schizophrenia: A Computational Reinforcement Learning Perspective

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Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity

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Texture of locomotor path: a replicable characterization of a complex behavioral phenotype

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Activity density in the open field: a measure for differentiating the effect of psychostimulants

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NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

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A Data Mining Approach to In Vivo Classification of Psychopharmacological Drugs

2008 • 20 citations

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

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Data mining in a behavioral test detects early symptoms in a model of amyotrophic lateral sclerosis.

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Inhibition of Dopaminergic Agonist-Induced Gnawing Behavior by Neuroleptic Drugs in Mice

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