Back to search

The Genome of the Kinetoplastid Parasite, Leishmania major

Data up to Jan 2025

Published2005
Citations1,324
References50

Total Citations Per Year

Abstract

References (50)

The Genome of the African Trypanosome Trypanosoma brucei

2005 • 1,617 citations

The Genome Sequence of Trypanosoma cruzi , Etiologic Agent of Chagas Disease

2005 • 1,321 citations

Comparative Genomics of Trypanosomatid Parasitic Protozoa

2005 • 807 citations

NEW EMBO MEMBER'S REVIEW Life without transcriptional control? From fly to man and back again

2002 • 532 citations

MEROPS: the peptidase database

2003 • 360 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

trans and cis Splicing in Trypanosomatids: Mechanism, Factors, and Regulation

2003 • 303 citations

The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function

2003 • 299 citations

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.

1994 • 269 citations

Transcription of Leishmania major Friedlin Chromosome 1 Initiates in Both Directions within a Single Region

2003 • 267 citations

Leishmania majorFriedlin chromosome 1 has an unusual distribution of protein-coding genes

1999 • 234 citations

The exosome of Trypanosoma brucei

2001 • 197 citations

Cell signalling andTrypanosoma cruziinvasion

2002 • 183 citations

A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA

2000 • 170 citations

Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?

2002 • 157 citations

The Leishmania Genome Comprises 36 Chromosomes Conserved Across Widely Divergent Human Pathogenic Species

1996 • 151 citations

Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha.

1998 • 144 citations

Transcription Initiation and Termination on Leishmania major Chromosome 3

2004 • 144 citations

Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human

2001 • 142 citations

ABrugia malayiHomolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection

2001 • 129 citations

The transcriptional complexity of the TFIIH complex

2003 • 126 citations

Trypanosoma brucei contains two RNA polymerase II largest subunit genes with an altered C-terminal domain

1989 • 116 citations

Migration Inhibitory Factor Induces Killing ofLeishmania majorby Macrophages: Dependence on Reactive Nitrogen Intermediates and Endogenous TNF-α

1998 • 109 citations

A differentially expressed gene family encoding “amastin,” a surface protein of Trypanosoma cruzi amastigotes.

1994 • 108 citations

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability

2001 • 106 citations

Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis

2005 • 106 citations

Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes

1998 • 105 citations

Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp.

2005 • 101 citations

Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity

2004 • 98 citations

Chagasin, the endogenous cysteine-protease inhibitor ofTrypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells

2005 • 88 citations

Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene

2003 • 73 citations

The sequence and analysis of Trypanosoma brucei chromosome II

2003 • 67 citations

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional “strand-switch” domain as a major feature

2005 • 65 citations

Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression

2002 • 63 citations

The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism

2003 • 63 citations

A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite

2004 • 59 citations

Leishmania major Elongation Factor 1B Complex Has Trypanothione S-Transferase and Peroxidase Activity

2004 • 57 citations

Functional Characterization of a Trypanosoma brucei TATA-Binding Protein-Related Factor Points to a Universal Regulator of Transcription in Trypanosomes

2004 • 56 citations

Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei

2003 • 44 citations

The Trypanosomatid Signal Recognition Particle Consists of Two RNA Molecules, a 7SL RNA Homologue and a Novel tRNA-like Molecule

2003 • 43 citations

Shotgun optical mapping of the entire Leishmania major Friedlin genome

2004 • 43 citations

The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end

2000 • 42 citations

Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania major-Sand Fly Interactions

2003 • 39 citations

Cloning and Characterization of Leishmania donovani Telomeres

2000 • 36 citations

Eubacterial HslV and HslU Subunits Homologs in Primordial Eukaryotes

2002 • 34 citations

Tetrahymena Elongation Factor-1 Is Localized with Calmodulin in the Division Furrow

2000 • 29 citations

Secondary DNA structure analysis of the coding strand switch regions of five Leishmania major Friedlin chromosomes

2001 • 23 citations

High conservation of the fine-scale organisation of chromosome 5 between two pathogenic Leishmania species

1999 • 21 citations

The Histone Minority Report

2003 • 16 citations

Engines of gene expression

2000 • 9 citations

Cited By (0)

Loading...
The Genome of the Kinetoplastid Parasite, Leishmania major (2005) – Science | Metascience Observatory Explorer