The Genome of the Kinetoplastid Parasite, Leishmania major
Data up to Jan 2025
Total Citations Per Year
Abstract
References (50)
The Genome of the African Trypanosome Trypanosoma brucei
2005 • 1,617 citations
The Genome Sequence of Trypanosoma cruzi , Etiologic Agent of Chagas Disease
2005 • 1,321 citations
Comparative Genomics of Trypanosomatid Parasitic Protozoa
2005 • 807 citations
NEW EMBO MEMBER'S REVIEW Life without transcriptional control? From fly to man and back again
2002 • 532 citations
MEROPS: the peptidase database
2003 • 360 citations
The Interaction of Leishmania Species with Macrophages
1992 • 323 citations
trans and cis Splicing in Trypanosomatids: Mechanism, Factors, and Regulation
2003 • 303 citations
The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function
2003 • 299 citations
A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.
1994 • 269 citations
Transcription of Leishmania major Friedlin Chromosome 1 Initiates in Both Directions within a Single Region
2003 • 267 citations
Leishmania majorFriedlin chromosome 1 has an unusual distribution of protein-coding genes
1999 • 234 citations
The exosome of Trypanosoma brucei
2001 • 197 citations
Cell signalling andTrypanosoma cruziinvasion
2002 • 183 citations
A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA
2000 • 170 citations
Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?
2002 • 157 citations
The Leishmania Genome Comprises 36 Chromosomes Conserved Across Widely Divergent Human Pathogenic Species
1996 • 151 citations
Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha.
1998 • 144 citations
Transcription Initiation and Termination on Leishmania major Chromosome 3
2004 • 144 citations
Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human
2001 • 142 citations
ABrugia malayiHomolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection
2001 • 129 citations
The transcriptional complexity of the TFIIH complex
2003 • 126 citations
Trypanosoma brucei contains two RNA polymerase II largest subunit genes with an altered C-terminal domain
1989 • 116 citations
Migration Inhibitory Factor Induces Killing ofLeishmania majorby Macrophages: Dependence on Reactive Nitrogen Intermediates and Endogenous TNF-α
1998 • 109 citations
A differentially expressed gene family encoding “amastin,” a surface protein of Trypanosoma cruzi amastigotes.
1994 • 108 citations
Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability
2001 • 106 citations
Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis
2005 • 106 citations
Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes
1998 • 105 citations
Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp.
2005 • 101 citations
Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity
2004 • 98 citations
Chagasin, the endogenous cysteine-protease inhibitor ofTrypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells
2005 • 88 citations
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene
2003 • 73 citations
The sequence and analysis of Trypanosoma brucei chromosome II
2003 • 67 citations
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional “strand-switch” domain as a major feature
2005 • 65 citations
Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression
2002 • 63 citations
The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism
2003 • 63 citations
A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite
2004 • 59 citations
Leishmania major Elongation Factor 1B Complex Has Trypanothione S-Transferase and Peroxidase Activity
2004 • 57 citations
Functional Characterization of a Trypanosoma brucei TATA-Binding Protein-Related Factor Points to a Universal Regulator of Transcription in Trypanosomes
2004 • 56 citations
Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei
2003 • 44 citations
The Trypanosomatid Signal Recognition Particle Consists of Two RNA Molecules, a 7SL RNA Homologue and a Novel tRNA-like Molecule
2003 • 43 citations
Shotgun optical mapping of the entire Leishmania major Friedlin genome
2004 • 43 citations
The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end
2000 • 42 citations
Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania major-Sand Fly Interactions
2003 • 39 citations
Cloning and Characterization of Leishmania donovani Telomeres
2000 • 36 citations
Eubacterial HslV and HslU Subunits Homologs in Primordial Eukaryotes
2002 • 34 citations
Tetrahymena Elongation Factor-1 Is Localized with Calmodulin in the Division Furrow
2000 • 29 citations
Secondary DNA structure analysis of the coding strand switch regions of five Leishmania major Friedlin chromosomes
2001 • 23 citations
High conservation of the fine-scale organisation of chromosome 5 between two pathogenic Leishmania species
1999 • 21 citations
The Histone Minority Report
2003 • 16 citations
Engines of gene expression
2000 • 9 citations