Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Revised methods for the Salmonella mutagenicity test

1983 • 7,295 citations

Histopathologic examination of the rat nasal cavity

1981 • 385 citations

Chemically‐induced unscheduled DNA synthesis in primary rat hepatocyte cultures: A comparison with bacterial mutagenicity using 218 compounds

1981 • 363 citations

Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a.

1986 • 341 citations

Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells

1975 • 309 citations

Mutagenicity screening of pesticides in the microbial system

1976 • 274 citations

Metabolic activation of carcinogens

1992 • 271 citations

Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2′-deoxyuridine and[³H]thymidine administered by injection or osmotic pump

1990 • 209 citations

An evaluation of the genotoxic properties of insecticides following plant and animal activation

1982 • 177 citations

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

1991 • 163 citations

Reproducibility of microbial mutagenicity assays: I. Tests withSalmonella typhimurium andEscherichia coli using a standardized protocol

1984 • 161 citations

Herbicide-induced DNA damage in human lymphocytes evaluated by the single-cell gel electrophoresis (SCGE) assay

1995 • 151 citations

Results of the National Alachlor Well Water Survey

1992 • 143 citations

Metabolic deactivation of mutagens in the Salmonella-microsome test

1978 • 118 citations

Drug Metabolism in the Nasal Cavity: Relevance to Toxicology

1993 • 112 citations

Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes

1988 • 104 citations

Olfactory Toxicity of Methimazole: Dose-Response and Structure-Activity Studies and Characterization of Flavin-Containing Monooxygenase Activity in the Long-Evans Rat Olfactory Mucosa

1995 • 104 citations

Cytogenetic effects of alachlor and/or atrazine in vivo and in vitro

1992 • 79 citations

Respiratory Tract Uptake of Inhalants and Metabolism of Xenobiotics

1993 • 77 citations

Nature of N-nitrosodimethylamine demethylase and its inhibitors.

1987 • 75 citations

Immunohistochemical Localization of a Cytochrome P-450 Isozyme in Human Nasal Mucosa: Age-Related Trends

1993 • 74 citations

Genotoxicity of the herbicides alachlor and maleic hydrazide in cultured human lymphocytes

1996 • 74 citations

Pesticide clastogenicity in Chinese hamster ovary cells

1987 • 70 citations

Dialkylquinoneimine metabolites of chloroacetanilide herbicides induce sister chromatid exchanges in cultured human lymphocytes

1997 • 70 citations

Unit Length as the Denominator for Quantitation of Cell Proliferation in Nasal Epithelia

1990 • 64 citations

Metabolism of alachlor by rat and mouse liver and nasal turbinate tissues.

1990 • 56 citations

Cytogenetic effects of alachlor and mancozeb

1983 • 52 citations

Regenerative Hyperplasia Is Not Required for Liver Tumor Induction in Female B6C3F1Mice Exposed to Trihalomethanes

1998 • 50 citations

Ethanol Increases Content and Activity of Human Cytochrome P4502E1 in a Transduced HepG2 Cell Line

1994 • 49 citations

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

1999 • 49 citations

Effects of P450 inhibition and induction on the olfactory toxicity of β, β′‐iminodipropionitrile (IDPN) in the rat

1994 • 48 citations

Age- and Gender-Related Trends in the Expression of Glutathione S-Transferases in Human Nasal Mucosa

1995 • 46 citations

Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.

1996 • 44 citations

Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Methods used and chemicals evaluated

1988 • 42 citations

Genotoxicity of four herbicides in the Drosophila wing spot test

1992 • 41 citations

Intraperitoneal Administration of Coumarin Causes Tissue-Selective Depletion of Cytochromes P450 and Cytotoxicity in the Olfactory Mucosa

1997 • 41 citations

Glutathione transferases in human nasal mucosa

1989 • 41 citations

Investigation of mechanisms of acetaminophen toxicity in isolated rat hepatocytes with the acetaminophen analogues 3,5-dimethylacetaminophen and 2,6-dimethylacetaminophen.

1987 • 40 citations

Genotoxic effects of the herbicides alachlor, atrazine, pendimethaline, and simazine in mammalian cells

1994 • 40 citations

DNA damage induced by alachlor after in vitro activation by rat hepatocytes

1992 • 39 citations

The detection of weak recombinogenic activities in the herbicides alachlor and propachlor using a plant-activation bioassay

1977 • 36 citations

Toxic and mutagenic action of the herbicide alachlor (lasso) on various strains of the nitrogen-fixing blue-green alga Nostoc muscorum and characterization of the herbicide-induced mutants resistant to methylamine and l-methionine-dl-sulfoximine

1979 • 36 citations

Distribution of Microsomal Epoxide Hydrolase and Glutathione S-transferase in the Rat Olfactory Mucosa: Relevance to Distribution of Lesions Caused by Systemically-administered Olfactory Toxicants

1995 • 34 citations

Induction of micronuclei in Vicia faba root tips treated in different soils with the herbicide alachlor

1990 • 34 citations

Dialkylquinonimines Validated as in Vivo Metabolites of Alachlor, Acetochlor, and Metolachlor Herbicides in Rats

1998 • 32 citations

Formation of reactive metabolites of phenacetin in humans and rats

1985 • 27 citations

The w/w⁺ SMART is a useful tool for the evaluation of pesticides

1994 • 25 citations

Early cell proliferative and cytotoxic effects of phenacetin on rat nasal mucosa

1989 • 24 citations

Identification of mercapturic acid pathway metabolites of alachlor formed by liver and kidney homogenates of rats, mice, and monkeys

1988 • 23 citations

Posttranscriptional Elevation of Cytochrome P450 3A Expression

1997 • 23 citations

THE AMES MUTAGEN ASSAY TESTED AGAINST HERBICIDES AND HERBICIDE COMBINATIONS

1981 • 21 citations

In vitro oxidation of alachlor by liver microsomal enzymes from rats, mice, and monkeys

1989 • 19 citations

MECHANISM OF INHIBITION OF HEPATIC BIOACTIVATION OF PARACETAMOL BY DIMETHYL SULFOXIDE

1988 • 13 citations

Influence of long-term ethanol treatment on rat liver aniline and p-nitrophenol hydroxylation

1996 • 12 citations

Genotoxicity of selected herbicides.

1989 • 9 citations

Micronuclei induced by alachlor, mitomycin-C and vinblastine in human lymphocytes: presence of centromeres and kinetochores and influence of staining technique

1996 • 8 citations

Identification of Human Genes Related to Olfactory-Specific CYP2G1

1996 • 8 citations

Stimulatory and inhibitory effects of dimethyl sulfoxide on microsomal aniline hydroxylase activity

1991 • 6 citations

Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.

1980 • 5 citations

Potent inhibition of MAO mediated propranolol metabolism by dimethyl sulfoxide in Hep G2 cells.

1992 • 2 citations