Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons

Proceedings of the National Academy of Sciences, USA

1996 • 1,621 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Polycyclic Hydrocarbons and Cancer

1981 • 737 citations

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules

1981 • 733 citations

The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation

1992 • 195 citations

Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

1995 • 176 citations

Role of radical cations in aromatic hydrocarbon carcinogenesis.

1985 • 174 citations

Polynuclear aromatic hydrocarbons : chemistry, metabolism, and carcinogenesis

1976 • 162 citations

Chemical Induction of Cancer

1953 • 157 citations

Biochemical Distinctions between the Nuclear and Microsomal Membranes from Rat Hepatocytes

1971 • 141 citations

Identification and quantitation of benzo[a]pyrene-DNA adducts formed in mouse skin

1993 • 121 citations

Preferential induction of aryl hydroxylase activity in rat liver nuclear envelope by 3-methylcholanthrene

1973 • 112 citations

Synthesis and identification of benzo[a]pyrene-guanine nucleoside adducts formed by electrochemical oxidation and by horseradish peroxidase catalyzed reaction of benzo[a]pyrene with DNA

1988 • 111 citations

Identification and quantitation of benzo[a]pyrene-DNA adducts formed by rat liver microsomes in vitro

1992 • 95 citations

The relationship between ionization potential and horseradish peroxidase/hydrogen peroxide-catalyzed binding of aromatic hydrocarbons to DNA

1983 • 95 citations

3-Methylcholanthrene-inducible binding of aromatic hydrocarbons to DNA in purified rat liver nuclei

1974 • 93 citations

Identification and Quantitation of Dibenzo[a,l]pyrene-DNA Adducts Formed by Rat Liver Microsomes in Vitro: Preponderance of Depurinating Adducts

1995 • 87 citations

Electrochemical oxidation pathways of benzo[a]pyrene

1970 • 77 citations

Binding of benzo[a]pyrene to DNA by cytochrome P 450 catalyzed one-electron oxidation in rat liver microsomes and nuclei

1990 • 74 citations

Involvement of Dihydrodiols and Diol Epoxides in the Metabolic Activation of Polycyclic Hydrocarbons Other than Benzo[a]pyrene

1981 • 70 citations

Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin

1993 • 69 citations

PHOTOCHEMICAL COUPLING OF BENZO[a]PYRENE WITH 1‐METHYLCYTOSINE; PHOTOENHANCEMENT OF CARCINOGENICITY

1971 • 64 citations

Mechanism of metabolic activation of the potent carcinogen 7,12-dimethylbenz[a]anthracene

1992 • 64 citations

Interaction of nucleic acids. IV. Physical binding of 3,4-benzopyrene to nucleosides, nucleotides, nucleic acids, and nucleoprotein

1968 • 61 citations

Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen.

1976 • 60 citations

Model adducts of benzo[a]pyrene and nucleosides formed from its radical cation and diol epoxide

1992 • 57 citations

Neue reaktionen der carcinogenen kohlenwasserstoffe 3,4-benzypyren, 9,10-dimethyl-1,2-benzanthracen und 20-methylcholanthren

1966 • 53 citations

Radical cations as precursors in the metabolic formation of quinones from benzo[a]pyrene and 6-fluorobenzo[a]pyrene

1988 • 52 citations

Synthesis and structure determination of the adducts of the potent carcinogen 7,12-dimethylbenz[a]anthracene and deoxyribonucleosides formed by electrochemical oxidation: models for metabolic activation by one-electron oxidation

1992 • 51 citations

Stereoelectronic effects in the deprotonation of arylalkyl radical cations: meso-ethylanthracenes

1990 • 46 citations

One-electron oxidation of aromatic hydrocarbons

1967 • 45 citations

One-electron oxidations by peroxidases

1995 • 44 citations

One electron transfer oxidation of 7,12-dimethylbenz[.alpha.]anthracene, a model for the metabolic activation of carcinogenic hydrocarbons

1967 • 43 citations

Interaction of nucleic acids. 7. Chemical linkage of polycyclic hydrocarbons to deoxyribonucleic acids and polynucleotides in aqueous solution and in a buffer-ethanol solvent system

1970 • 41 citations

Neue reaktionen der carcinogenen kohlenwasserstoffe—II

1967 • 40 citations

Synthesis and structure determination of the adducts formed by electrochemical oxidation of the potent carcinogen dibenzo[a,l]pyrene in the presence of nucleosides

1993 • 36 citations

Interaction of nucleic acids. V. Chemical linkage of 3,4-benzopyrene to deoxyribonucleic acid in aqueous solution

1969 • 36 citations

Effect of a 6-fluoro substituent on the metabolism and biological activity of benzo(a)pyrene.

1983 • 36 citations

Reactions Between Benzo[a]pyrene and Nucleobases by One-Electron Oxidation234

1972 • 35 citations

One-electron oxidation of 6-substituted benzo[a]pyrenes by manganic acetate. A model for metabolic activation

1989 • 35 citations

Reactions Between Activated Benzo[ a ]pyrene and Nucleophilic Compounds, With Possible Implications on the Mechanism of Tumor Initiation 2

1974 • 33 citations

Reaction of methylbenzanthracenes and pyridine by one-electron oxidation. A model for metabolic activation and binding of carcinogenic aromatic hydrocarbons

1976 • 33 citations

Radical cations in the horseradish peroxidase and prostaglandin H synthase mediated metabolism and binding of benzo[a]pyrene to deoxyribonucleic acid

1988 • 32 citations

Correlation studies of anodic peak potentials and ionization potentials for polycyclic aromatic hydrocarbons

1992 • 23 citations

One-electron oxidation of dibenzo[a]pyrenes by manganic acetate

1992 • 23 citations

Adducts of 6-methylbenzo[a]pyrene and 6-fluorobenzo[a]pyrene formed by electrochemical oxidation in the presence of deoxyribonucleosides

1993 • 18 citations

The relationship between ionization potential and prostaglandin H synthase-catalyzed binding of aromatic hydrocarbons to DNA

1987 • 16 citations

Tumorigenicity of 7,12-Dimethylbenz[a]anthracene, Some of Its Fluorinated Derivatives, and 1,2,3,4-Tetrahydro-7,12-dimethylbenz[a]anthracene in Mouse Skin and Rat Mammary Gland

1990 • 12 citations

Relative carcinogenicity of some diethylbenz[a]anthracenes

1972 • 12 citations

Metabolism of 1- and 3-Fluorobenzo[a]pyrene by Cytochrome p450 and Horseradish Peroxidase

1994 • 2 citations