Evolving role of theophylline for treatment of chronic childhood asthma

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1991 • 1,717 citations

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1990 • 1,318 citations

Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma

1985 • 1,315 citations

Rational Intravenous Doses of Theophylline

1973 • 666 citations

Effects of 22 Months of Treatment with Inhaled Corticosteroids and/or Beta-2-Agonists on Lung Function, Airway Responsiveness, and Symptoms in Children with Asthma

1992 • 459 citations

A New Approach to the Treatment of Asthma

1989 • 458 citations

Histamine Release in vitro: Inhibition by Catecholamines and Methylxanthines

1968 • 458 citations

Anti-inflammatory effects of low-dose oral theophylline in atopic asthma

1994 • 405 citations

THE FAMILY DOCTOR IN THE CONTEXT OF BRITAIN'S SOCIAL SERVICES.

1965 • 401 citations

The assessment and treatment of asthma: A conference report

1990 • 390 citations

Effect of Cyclic AMP on Release of Lysosomal Enzymes from Phagocytes

1971 • 380 citations

Comparison of Patients' Compliance With Prescribed Oral and Inhaled Asthma Medications

1994 • 325 citations

Management of asthma: a consensus statement.

1989 • 306 citations

A meta-analysis of the effect of oral and inhaled corticosteroids on growth

1994 • 303 citations

Aerosol Beclomethasone Dipropionate Compared With Theophylline as Primary Treatment of Chronic, Mild to Moderately Severe Asthma in Children

1993 • 300 citations

Effects of Theophylline on Diaphragmatic Strength and Fatigue in Patients with Chronic Obstructive Pulmonary Disease

1984 • 290 citations

Asthma: a follow up statement from an international paediatric asthma consensus group.

1992 • 255 citations

Factors affecting theophylline clearances: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol

1979 • 253 citations

Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells.

1991 • 235 citations

The effect of theophylline and enprofylline on allergen-induced bronchoconstriction

1985 • 223 citations

Regulation of interleukin 2 synthesis by cAMP in human T cells.

1987 • 197 citations

Altered Theophylline Clearance During an Influenza B Outbreak

1982 • 197 citations

Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea‐pigs: the effect of anti‐asthma drugs

1990 • 189 citations

Guidelines on the management of asthma. Statement by the British Thoracic Society, the Brit. Paediatric Association, the Research Unit of the Royal College of Physicians of London, the King's Fund Centre, the National Asthma Campaign, the Royal College of General Practitioners, the General Practitioners in Asthma Group, the Brit. Assoc. of Accident and Emergency Medicine, and the Brit. Paediatric Respiratory Group.

1993 • 180 citations

A Clinical and Pharmacokinetic Basis for the Selection and Use of Slow Release Theophylline Products

1984 • 158 citations

Theophylline—an Immunomodulatory Role in Asthma?

1993 • 153 citations

COMPARISON OF CROMOGLYCATE (CROMOLYN) AND THEOPHYLLINE IN CONTROLLING SYMPTOMS OF CHRONIC ASTHMA

1977 • 150 citations

Frequent Toxicity from IV Aminophylline Infusions in Critically Ill Patients

1977 • 148 citations

Inhibitors of Cyclic Nucleotide Phosphodiesterase Isoenzymes—their Potential Utility in the Therapy of Asthma

1994 • 134 citations

The value of maintenance theophylline in steroiddependent asthma

1981 • 133 citations

Behavior Abnormalities and Poor School Performance Due to Oral Theophylline Use

1986 • 126 citations

Need for theophylline in severe steroid‐requiring asthmatics

1988 • 124 citations

Frequent Toxicity from IV Aminophylline Infusions in Critically ILL Patients

2006 • 123 citations

The pathogenesis and significance of bronchial hyper-responsiveness in airways disease

1987 • 116 citations

A Double-Blind Study Comparing the Effectiveness of Cromolyn Sodium and Sustained-Release Theophylline in Childhood Asthma

1984 • 116 citations

Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate.

1991 • 115 citations

Pharmacologic Control of Plasma Exudation into Tracheobronchial Airways

1991 • 113 citations

Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig.

1989 • 110 citations

Diaphragmatic contractility enhanced by aminophylline: role of extracellular calcium

1983 • 103 citations

Eosinophil accumulation in pulmonary airways of guinea‐pigs induced by exposure to an aerosol of platelet‐activating factor: effect of anti‐asthma drugs

1990 • 99 citations

Cyclic nucleotides and modulation of effector systems of inflammation

1974 • 95 citations

Theophylline Has a Dose-related Effect on the Airway Response to Inhaled Histamine and Methacholine in Asthmatics

1987 • 92 citations

Polymorphonuclear Leukocyte Inhibition by Therapeutic Concentrations of Theophylline Is Mediated by Cyclic-3′, 5′-Adenosine Monophosphate

1988 • 91 citations

Local Allergen Challenge and Bronchoalveolar Lavage of Allergic Asthmatic Lungs

2015 • 89 citations

Twenty-four Hour Lung Function in Adult Patients with Asthma: Chronoptimized Theophylline Therapy Once-daily Dosing in the Evening versus Conventional Twice-daily Dosing

1990 • 84 citations

Relative efficacy of maintenance therapy with theophylline, inhaled albuterol, and the combination for chronic asthma***

1987 • 83 citations

Effect of Theophylline and Adenosine on Eosinophil Function

1989 • 79 citations

Does Asthma or Treatment with Theophylline Limit Children's Academic Performance?

1992 • 77 citations

Circadian Variations in Theophylline Concentrations and the Treatment of Nocturnal Asthma

1989 • 75 citations

Safety and efficacy of theophylline in children with asthma

1992 • 72 citations

The relationship between airway inflammation and bronchial hyperresponsiveness

1989 • 72 citations

Update on the Pharmacodynamics and Pharmacokinetics of Theophylline

1985 • 59 citations

Theophylline and the immune response: In vitro and in vivo effects

1988 • 58 citations

Comparison of human lung and intestinal mast cells

1988 • 55 citations

Effect of dietary protein and carbohydrate on theophylline metabolism in children.

1980 • 55 citations

Induction of suppressor T cells in asthmatic children by theophylline treatment

1983 • 54 citations

Modulation of superoxide production of alveolar macrophages and peripheral blood mononuclear cells by beta-agonists and theophylline.

1991 • 51 citations

Theophylline‐induced alterations in cellular immunity in asthmatic patients

1987 • 49 citations

Effect of Dietary Protein and Carbohydrate on Theophylline Metabolism in Children

1980 • 49 citations

Nocturnal asthma: slow-release terbutaline versus slow-release theophylline therapy

1988 • 48 citations

Theophylline-Induced Behavior Change in Children

1992 • 47 citations

Clinical, physiologic, and psychologic comparison of treatment by cromolyn or theophylline in childhood asthma

1985 • 46 citations

Effects of Theophylline on Behavior and Learning in Children With Asthma

1989 • 46 citations

Theophylline attenuation of airway responses to allergen: Comparison with cromolyn metered-dose inhaler

1995 • 42 citations

Neurogenic Inflammation in the Airways: I. Neurogenic Stimulation Induces Plasma Protein Extravasation into the Rat Airway Lumen

1989 • 41 citations

Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: Influence of erythromycin

1982 • 41 citations

Comparison of Once-Daily Evening Versus Morning Sustained-Release Theophylline Dosing For Nocturnal Asthma

1987 • 41 citations

Effect of therapeutic plasma concentrations of theophylline on behavior, cognitive processing, and affect in children with asthma

1991 • 41 citations

Partial inhibition of the early and late asthmatic response by a single dose of salmeterol.

1994 • 40 citations

Extrapulmonary effects of maintenance therapy with theophylline and inhaled albuterol in patients with chronic asthma

1986 • 40 citations

The Effects of Theophylline on Airway Inflammation

1987 • 40 citations

The pulmonary disposition of theophylline and its influence on human alveolar macrophage bactericidal function.

1986 • 39 citations

Multiple mechanisms of xanthine actions on airway reactivity.

1990 • 36 citations

Theophylline Metabolism during the First Month of Life and Development

1981 • 35 citations

Comparison of orally administered metaproterenol and theophylline in the control of chronic asthma

1982 • 34 citations

Avoidance of Adverse Effects during Chronic Therapy with Theophylline

1980 • 32 citations

Cholinergic and neurogenic mechanisms in obstructive airways disease

1986 • 30 citations

The effect of maintenance theophylline therapy on lung work in severe chronic obstructive pulmonary disease while standing and walking.

1984 • 28 citations

Long-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma

1990 • 26 citations

The effect of theophyllamine on T-lymphocyte activation in vitro

1984 • 23 citations

Psychological change associated with theophylline treatment of asthmatic children: A 6‐month study

1991 • 22 citations

Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP.

1980 • 22 citations

Effect of theophylline, terbutaline, and their combination on the immediate hypersensitivity skin-test reaction

1980 • 22 citations

Theophylline—How much is enough?

1986 • 22 citations

Behavioral and cognitive effect of theophylline: a dose-response study.

1993 • 17 citations

Theophylline reduces pulmonary eosinophilia after various types of active anaphylactic shock in guinea-pigs

1991 • 13 citations

Asthma--something old, something new ....

1991 • 8 citations

Pharmacology of Upper Airways Challenge

1987 • 7 citations

Theophylline inhibition of BCG-induced pulmonary inflammatory responses.

1990 • 4 citations

Deleted Work

1955 • 0 citations