A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age

A simple technique for quantitation of low levels of DNA damage in individual cells

1988 • 10,537 citations

Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set

2002 • 1,839 citations

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

2010 • 1,597 citations

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

2010 • 1,330 citations

Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

1980 • 1,265 citations

Variations of Bacterial Populations in Human Feces Measured by Fluorescent In Situ Hybridization with Group-Specific 16S rRNA-Targeted Oligonucleotide Probes

1998 • 1,064 citations

Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study

2006 • 927 citations

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

2009 • 892 citations

Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces

2006 • 888 citations

Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut

2006 • 734 citations

Characterization of Bacterial Communities in Feces from Healthy Elderly Volunteers and Hospitalized Elderly Patients by Using Real-Time PCR and Effects of Antibiotic Treatment on the Fecal Microbiota

2004 • 710 citations

Dietary prebiotics: current status and new definition

2010 • 697 citations

Regulatory effects of bifidobacteria on the growth of other colonic bacteria

1994 • 693 citations

Acetate Utilization and Butyryl Coenzyme A (CoA):Acetate-CoA Transferase in Butyrate-Producing Bacteria from the Human Large Intestine

2002 • 644 citations

Comparison of fermentation reactions in different regions of the human colon

1992 • 628 citations

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles

2001 • 561 citations

Clinical trial: the effects of a trans‐galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome

2008 • 514 citations

Validation of a Three-Stage Compound Continuous Culture System for Investigating the Effect of Retention Time on the Ecology and Metabolism of Bacteria in the Human Colon

1998 • 511 citations

Human colonic biota studied by ribosomal DNA sequence analysis

1996 • 501 citations

Cholesterol Assimilation by Lactic Acid Bacteria and Bifidobacteria Isolated from the Human Gut

2002 • 468 citations

Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults

2009 • 468 citations

Quantitative PCR Targeting 16S rRNA and Reductive Dehalogenase Genes Simultaneously Monitors Multiple Dehalococcoides Strains

2006 • 444 citations

Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection

2002 • 443 citations

Intestinal bacteria and ageing

2007 • 437 citations

Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers

2008 • 419 citations

The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study

2004 • 399 citations

Comparison of Compositions and Metabolic Activities of Fecal Microbiotas in Young Adults and in Antibiotic-Treated and Non-Antibiotic-Treated Elderly Subjects

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The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides – a human volunteer study

2001 • 307 citations

Human Colonic Bacteria: Role in Nutrition, Physiology, and Pathology

1995 • 286 citations

Colonic Microbiota Signatures across Five Northern European Countries

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Prebiotic Capacity of Inulin-Type Fructans

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Comparison of fermentation reactions in different regions of the human colon

1992 • 260 citations

Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study

2008 • 251 citations

Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations

2009 • 248 citations

The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

2009 • 221 citations

Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria

2004 • 191 citations

Effects of Administration of Galactooligosaccharides on the Human Faecal Microflora, Stool Weight and Abdominal Sensation

1990 • 189 citations

Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly

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Effects of Administration of Galactooligosaccharides on the Human Faecal Microflora, Stool Weight and Abdominal Sensation

1990 • 171 citations

Carbohydrate Fermentation, Energy Transduction and Gas Metabolism in the Human Large Intestine

1997 • 161 citations

Polydextrose, Lactitol, and Fructo-Oligosaccharide Fermentation by Colonic Bacteria in a Three-Stage Continuous Culture System

2004 • 152 citations

Amount and fate of egg protein escaping assimilation in the small intestine of humans

1999 • 136 citations

Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers

2007 • 131 citations

Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources

1997 • 126 citations

New insight into butyrate metabolism

2003 • 124 citations

Colon Mucosal Cell Damage by Ammonia in Rats

1991 • 121 citations

Validation of an in vitro assay for predicting the amount of starch that escapes digestion in the small intestine of humans

1993 • 113 citations

Galacto‐oligosaccharides Are Bifidogenic and Safe at Weaning: A Double‐blind Randomized Multicenter Study

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Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S -transferases genes, an approach in nutrigenomics

2005 • 106 citations

Effects of high-resistant-starch banana flour (RS2) on in vitro fermentation and the small-bowel excretion of energy, nutrients, and sterols: an ileostomy study

2002 • 99 citations

Diet, fecal water, and colon cancer - development of a biomarker

2009 • 96 citations

Selective Plating Underestimates Abundance and Shows Differential Recovery of Bifidobacterial Species from Human Feces

2003 • 92 citations

Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids

2007 • 88 citations

Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects

2003 • 87 citations

The Effect of Cruciferous and Leguminous Sprouts on Genotoxicity, In vitro and In vivo

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Gastrointestinal tract and the elderly: functional foods, gut microflora and healthy ageing

2002 • 76 citations

Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model

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Inter- and intra-individual variation of faecal water — genotoxicity in human colon cells

2000 • 50 citations

Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats

2008 • 49 citations

Effect of short-chain carbohydrates on human intestinal bifidobacteria and Escherichia coli in vitro

2001 • 26 citations

Cytokinesis-Block Micronucleus Cytome Assays for the Determination of Genotoxicity and Cytotoxicity of Cecal Water in Rats and Fecal Water in Humans

2007 • 16 citations

Yoghurt containing galactooligosaccharides facilitates defecation among elderly subjects and selectively increases the number of bifidobacteria.

2009 • 13 citations

Introduction: dietary fibre, butyrate and colorectal cancer

1995 • 13 citations