Expression of CCR5 Increases during Monocyte Differentiation and Directly Mediates Macrophage Susceptibility to Infection by Human Immunodeficiency Virus Type 1

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Decay characteristics of HIV-1-infected compartments during combination therapy

1997 • 1,849 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

1997 • 1,373 citations

The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

1996 • 1,364 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

The V3 domain of the HIV–1 gp120 envelope glycoprotein is critical for chemokine–mediated blockade of infection

1996 • 499 citations

Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes

1988 • 486 citations

The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

1997 • 454 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection

1997 • 398 citations

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

1997 • 363 citations

Rapid killing of actinomycin D-treated tumor cells by human mononuclear cells. I. Effectors belong to the monocyte-macrophage lineage.

1984 • 271 citations

Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis

1990 • 231 citations

Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology Laboratories

1992 • 229 citations

Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes

1996 • 221 citations

Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV-1).

1992 • 220 citations

Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections.

1989 • 212 citations

CCR5 Expression Correlates with Susceptibility of Maturing Monocytes to Human Immunodeficiency Virus Type 1 Infection

1998 • 207 citations

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1995 • 199 citations

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

1991 • 187 citations

Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages.

1992 • 183 citations

Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor

1997 • 165 citations

CD8⁺T-cell-derived soluble factor(s), but not β-chemokines RANTES, MIP-1α, and MIP-1β, suppress HIV-1 replication in monocyte/macrophages

1996 • 162 citations

Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system

1992 • 156 citations

Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients

1995 • 145 citations

Distribution of the cyclosporine binding protein cyclophilin in human tissues.

1991 • 142 citations

Chemokine receptors and HIV

1997 • 135 citations

Cytokines alter production of HIV-1 from primary mononuclear phagocytes

1988 • 111 citations

CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children

1996 • 78 citations

Susceptibility of Human Monocytes to HIV Type 1 Infectionin VitroIs Not Dependent on Their Level of CD4 Expression

1995 • 53 citations

Evidence for RANTES, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 beta expression in Kawasaki disease.

1997 • 52 citations

Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro

1996 • 47 citations

Human cord blood mononuclear cells are preferentially infected by non-syncytium-inducing, macrophage-tropic human immunodeficiency virus type 1 isolates

1995 • 46 citations

Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation

1997 • 37 citations

Arrested rearrangement of TCR V beta genes in thymocytes from children with X-linked severe combined immunodeficiency disease.

1994 • 28 citations

Zidovudine administered to women infected with human immunodeficiency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus

1997 • 27 citations

Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation

1991 • 18 citations

Blood Monocytes InfectedIn Vivoby HIV-1 Variants with a Syncytium-Inducing Phenotype

1994 • 17 citations

Quantitative RT-PCR

2003 • 17 citations

HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429

1994 • 17 citations

Molecular analysis of highly enriched populations of T-cell-depleted monocytes

1995 • 16 citations

Deleted Work

1955 • 0 citations