ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Preparation and Analysis of DNA

2012 • 439 citations

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

1989 • 372 citations

Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells

1992 • 257 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency

1993 • 233 citations

Relationship Between the Envelope and the Infectivity of Herpes Simplex Virus.

1964 • 220 citations

Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon

2000 • 218 citations

The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27

1997 • 188 citations

Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

1987 • 183 citations

Herpes simplex virus latency

1984 • 180 citations

Repression of viral transcription during herpes simplex virus latency

2000 • 159 citations

Mechanisms of herpes simplex virus type 1 reactivation

1996 • 152 citations

Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system

1989 • 132 citations

A viral activator of gene expression functions via the ubiquitin-proteasome pathway

1998 • 119 citations

Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts

1991 • 118 citations

A Herpes Simplex Virus Type 1 Mutant Containing a Deletion within Immediate Early Gene 1 Is Latency-competent in Mice

1989 • 95 citations

Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products

1990 • 95 citations

Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis

1997 • 85 citations

Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: Correlation of the physical and genetic maps

1980 • 75 citations

Herpes Simplex Virus Latency

1985 • 63 citations

Recombination between temperature-sensitive mutants of herpes simplex virus type 1

1974 • 60 citations

Optimized Viral Dose and Transient Immunosuppression Enable Herpes Simplex Virus ICP0-Null Mutants To Establish Wild-Type Levels of Latency In Vivo

2000 • 49 citations

Heat shock-induced reactivation of herpes simplex virus type 1 in latently infected mouse trigeminal ganglion cells in dissociated culture

1994 • 31 citations

Effects of Cyclophosphamide on Lymphoid Tissues Labelled with 5-Iodo-2-Deoxyuridine-<sup>125</sup>I and <sup>51</sup>Cr

1972 • 29 citations

The Recovery of Immune Responsiveness after Treatment with Cyclophosphamide

1971 • 22 citations

The effect of microsomal enzyme inhibition on the immunosuppressive and toxic effects of cyclophosphamide.

1973 • 19 citations

Physical mapping of herpes simplex virus-coded functions and polypeptides by marker rescue and analysis of HSV-1/HSV-2 intertypic recombinants.

1978 • 16 citations