The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Simultaneous Statistical Inference

1981 • 5,665 citations

Asymptotically Efficient Rank Invariant Test Procedures

1972 • 3,392 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Handbook of the Biology of Aging

1978 • 871 citations

The Rate of Living.

1928 • 686 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

Handbook of the Biology of Aging

1986 • 572 citations

Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments.

1980 • 465 citations

Longevity, senescence, and the genome

1992 • 409 citations

Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology

1985 • 356 citations

Expected values of normal order statistics

1961 • 341 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

Hypothesis

1985 • 272 citations

Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes

1985 • 265 citations

Pathobiology of the Aging Rat

1993 • 252 citations

Effects of Starvation in Rats on Serum Levels of Follicle Stimulating Hormone, Luteinizing Hormone, Thyrotropin, Growth Hormone and Prolactin; Response to LH-Releasing Hormone and Thyrotropin-Releasing Hormone

1977 • 214 citations

Does food restriction retard aging by reducing the metabolic rate?

1985 • 212 citations

Changes in Adipose Mass and Cellularity Through the Adult Life of Rats Fed Ad Libitum or a Life-Prolonging Restricted Diet

1980 • 203 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

A Guide to Practical Stereology

1984 • 166 citations

Evidence for the central role of glomerular growth promoters in the development of sclerosis.

1989 • 154 citations

Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein

1989 • 154 citations

A Guide to Practical Stereology

1983 • 149 citations

Evidence for the Glycation Hypothesis of Aging From the Food-Restricted Rodent Model

1989 • 147 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Influence of the Restriction of Individual Dietary Components on Longevity And Age-Related Disease of Fischer Rats: The Fat Component and the Mineral Component

1988 • 132 citations

Effect of chronic food restriction in aging rats II. Liver cytosolic antioxidants and related enzymes

1989 • 127 citations

Growth, Body Weight, Survival, and Tumor Trends in F344/N Rats during an Eleven-Year Period

1990 • 120 citations

International Review of Experimental Pathology

1977 • 117 citations

Retardation of the Aging Processes in Rats by Food Restriction

1991 • 115 citations

Oxygen radicals in biology and medicine

1989 • 112 citations

Neoplasms and Related Proliferative Lesions in Control Sprague-Dawley Rats from Carcinogenicity Studies. Historical Data and Diagnostic Considerations

1992 • 101 citations

New aspects of the dietary effect of life prolongation in rodents. What is the role of obesity in aging?

1975 • 101 citations

Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: I. Effects on Spontaneous Neoplasms

1995 • 97 citations

Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions

1995 • 96 citations

Transient reduction of metabolic rate by food restriction

1989 • 96 citations

Morphometry in experimental pathology: methods, baseline data and applications.

1976 • 94 citations

Modulation of free radicals and superoxide dismutases by age and dietary restriction

1990 • 90 citations

Effect of chronic food restriction in aging rats I. Liver subcellular membranes

1989 • 79 citations

Effects of Corn Oil, Time-Related Changes, and Inter-Laboratory Variability on Tumor Occurrence in Control Fischer 344 (F344/N) Rats

1992 • 78 citations

Altered norepinephrine uptake in neuronal cultures from spontaneously hypertensive rat brain

1985 • 76 citations

Early indicators for carcinogenesis in sex-hormone-sensitive organs

1991 • 73 citations

Aging: Hypothalamic Catecholamines, Neuroendocrine-Immune Interactions, and Dietary Restriction

1990 • 71 citations

Life Span, Morphology, and Pathology of Diet-Restricted Germ-Free and Conventional Lobund-Wistar Rats

1990 • 69 citations

Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate

1992 • 62 citations

The Early Effects of Dietary Restriction on the Pathogenesis of Chronic Renal Disease in Sprague-Dawley Rats at 12 Months

1993 • 57 citations

Use of rodents as models for the study of “normal aging”: Conceptual and practical issues

1991 • 55 citations

Free Radicals in Aging

1993 • 50 citations

Fat, Frail and Dying Young: Survival, Body Weight and Pathology of the Charles River Sprague-Dawley-Derived Rat Prior to and Since the Introduction of the VAFR Variant in 1988

1993 • 49 citations

Morphometric Methods in Veterinary Pathology: A Review

1980 • 46 citations

Influence of Life-Prolonging Food Restriction on Membrane Lipoperoxidation and Antioxidant Status

1988 • 44 citations

Dietary Restriction and Aging

1989 • 42 citations

Risks of Premature Death and Cancer Predicted by Body Weight in Early Adult Life

1991 • 36 citations

Aging as a consequence of fuel utilization

1991 • 34 citations

Myocardial Fibrosis in Aging Germ-free and Conventional Lobund-wistar Rats: the Protective Effect of Diet Restriction

1991 • 31 citations

Biological Effects of Dietary Restriction

1990 • 31 citations

1200-Rat Biosure Study: Design and Overview of Results

1991 • 27 citations

Aging and proliferative homeostasis: modulation by food restriction in rodents.

1992 • 27 citations

Studies on prolactin-secreting cells in aging rats of different strains. I. Alterations in pituitary histology and serum prolactin levels as related to aging

1988 • 25 citations

Action of Food Restriction on Age-related Changes in Adipocyte Lipolysis

1987 • 25 citations

Biology of aging: facts, thoughts, and experimental approaches.

1991 • 24 citations

FDA requirements for nonclinical testing of contraceptive steroids

1992 • 19 citations

AGING: A THEORY BASED ON FREE RADICAL AND RADIATION CHEMISTRY

1955 • 19 citations

Evidence that underfeeding acts via the neuroendocrine system to influence aging processes.

1989 • 18 citations

Relation of the Neuroendocrine System to Development of Prolactin-Secreting Pituitary Tumors

1983 • 18 citations

Studies on prolactin-secreting cells in aging rats of different strains. II. Selected morphological and immunocytochemical features of pituitary tumors correlated with serum prolactin levels

1988 • 15 citations

AN ELECTRON MICROSCOPIC EXAMINATION OF AGE‐RELATED CHANGES IN THE RAT LIVER. The Influence of Diet

1988 • 14 citations

Spontaneous pituitary gonadotroph nodules in aging male Lobund-Wistar rats.

1989 • 9 citations