Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.

1987 • 400 citations

Multiple biological activities of human recombinant interleukin 1.

1986 • 372 citations

Serum Lipids in Infection

1969 • 371 citations

Studies of endotoxin-induced decrease in lipoprotein lipase activity.

1981 • 333 citations

Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.

1990 • 324 citations

Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins.

1989 • 302 citations

The use of a non‐ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions

1967 • 292 citations

New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides.

1979 • 290 citations

Lipids, lipoproteins, and apoproteins in serum during infection.

1986 • 290 citations

Changes in serum lipoprotein pattern induced by acute infections

1988 • 283 citations

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.

1986 • 280 citations

Selective measurement of two different triglyceride lipase activities in rat postheparin plasma

1973 • 249 citations

Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.

1985 • 235 citations

A rapid assay for lipoprotein lipase

1970 • 225 citations

Multiple Cytokines Stimulate Hepatic Lipid Synthesisin Vivo*

1989 • 209 citations

New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma.

1981 • 207 citations

The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide.

1986 • 190 citations

Tumor Necrosis Factor Stimulates Hepatic Lipid Synthesis and Secretion*

1989 • 183 citations

Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia.

1989 • 128 citations

Biological Activity, Lipoprotein-binding Behavior, and In Vivo Disposition of Extracted and Native Forms of Salmonella typhimurium Lipopolysaccharides

1982 • 126 citations

Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion

1985 • 111 citations

Hypertriglyceridemia Produced by Endotoxin: Role of Impaired Triglyceride Disposal Mechanisms

1976 • 111 citations

Hyperlipidemia, fatty liver, and bromsulfo-phthalein retention in rabbits injected intravenously with bacterial endotoxins

1964 • 106 citations

Mechanism of the hypertriglyceridemia induced by tumor necrosis factor administration to rats

1989 • 92 citations

Effect of interleukin-1 on lipid metabolism in the rat. Similarities to and differences from tumor necrosis factor.

1991 • 91 citations

THE MECHANISM RESPONSIBLE FOR THE HYPERCHOLESTEREMIA INDUCED BY TRITON WR-1339

1953 • 85 citations

Role of the Liver in Regulation of Ketone Body Production during Sepsis

1979 • 73 citations

The Effect of Diabetes Mellitus on Sterol Synthesis in the Intact Rat

1982 • 67 citations

Tumor Necrosis Factor Acutely Increases Plasma Levels of Very Low Density Lipoproteins of Normal Size and Composition*

1990 • 65 citations

Defective lipid disposal mechanisms during bacterial infection in rhesus monkeys

1976 • 63 citations

Diet affects the mechanisms by which TNF stimulates hepatic triglyceride production

1990 • 62 citations

Alterations of Lipid Metabolism in Mice Injected with Endotoxin

1979 • 61 citations

Alterations in Lipogenic Enzymes and Lipoprotein Lipase Activity During Gram-Negative Sepsis in the Rat

1982 • 59 citations

Role for monokines in the metabolic effects of endotoxin. Interferon-gamma restores responsiveness of C3H/HeJ mice in vivo.

1992 • 57 citations

Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats

1990 • 56 citations

Herpes Simplex Virus Binds to Human Serum Lipoprotein

1988 • 51 citations

Lipoprotein lipase activity in rat heart and adipose tissue during endotoxic shock

1980 • 51 citations

Effects of Three Bacterial Infections on Serum Lipids of Rabbits

1968 • 51 citations

General considerations of the interferon system.

1981 • 50 citations

Neutralization and Lipoprotein Binding of Lipopolysaccharides in Tolerant Rabbit Serum

1986 • 50 citations

Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-alpha.

1991 • 49 citations

Role of Metabolism in Pathogenesis of Bacteremia Due to Diplococcus pneumoniae in Rabbits

1973 • 49 citations

THE PATHOGENESIS OF HYPERLIPEMIA INDUCED BY MEANS OF SURFACE-ACTIVE AGENTS

1956 • 48 citations

Electrophoretic separation of proteins on agarose gel—Application for direct immunization with a gel piece containing an antigen

1987 • 46 citations

De novo sterologenesis in the intact rat

1983 • 46 citations

Roles of interleukin-1 and tumor necrosis factor in lipopolysaccharide-induced hypoglycemia

1991 • 45 citations

Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic virus is associated with mouse serum lipoproteins.

1977 • 44 citations

Triacylglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity

1987 • 42 citations

THE EFFECTS OF BACTERIAL ENDOTOXIN ON LIPIDE METABOLISM

1959 • 42 citations

The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis

1990 • 36 citations

Activity of human serum lipoproteins on the infectivity of rhabdoviruses.

1983 • 35 citations

Differential inhibition of lipopolysaccharide-induced phenomena by anti-tumor necrosis factor alpha antibody

1990 • 31 citations

Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: evidence for the possible involvement of insulin

1989 • 30 citations

Endotoxemia in the Rhesus Monkey: Alterations in Host Lipid and Carbohydrate Metabolism

1974 • 24 citations

Endotoxin influence on lipolysis in isolated human and primate adipocytes

1977 • 18 citations

Lipopolysaccharide toxin can directly stimulate the intracellular accumulation of lipids and their secretion into medium in the primary culture of rabbit hepatocytes

1989 • 15 citations

The relationship of plasma catecholamines to serum triglycerides in canine gram-negative bacteremia.

1972 • 15 citations

Alterations in Plasma and Brain Lipid Metabolism during Endotoxemia in the Neonatal Rat

1973 • 14 citations

Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis

1990 • 12 citations

Interleukins, lymphokines, and cytokines : proceedings of the Third International Lymphokine Workshop

1983 • 10 citations

Gram-positive bacterial sepsis in rat and tissue lipolytic activity on commercial parenteral fat emulsions

1990 • 7 citations