Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

1996 • 7,450 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

2004 • 6,926 citations

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

2002 • 6,780 citations

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins

2005 • 6,633 citations

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

2008 • 6,182 citations

Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels

1998 • 5,293 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

2004 • 4,752 citations

Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial

1993 • 4,132 citations

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial

2003 • 3,816 citations

Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

2004 • 3,776 citations

Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

2009 • 3,737 citations

Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease

2005 • 3,404 citations

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

2002 • 3,347 citations

High-Dose Atorvastatin after Stroke or Transient Ischemic Attack

2006 • 2,685 citations

Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis

2005 • 2,496 citations

Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths

2007 • 2,221 citations

Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis

2009 • 1,901 citations

Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?

2014 • 1,880 citations

High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention After Myocardial Infarction<SUBTITLE>The IDEAL Study: A Randomized Controlled Trial</SUBTITLE>

2005 • 1,556 citations

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

2004 • 1,514 citations

Rosuvastatin in Older Patients with Systolic Heart Failure

2007 • 1,456 citations

Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes

2004 • 1,335 citations

Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT)

2002 • 1,311 citations

Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention Trial

1989 • 1,123 citations

Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

2008 • 1,076 citations

The Effect of Aggressive Lowering of Low-Density Lipoprotein Cholesterol Levels and Low-Dose Anticoagulation on Obstructive Changes in Saphenous-Vein Coronary-Artery Bypass Grafts

1997 • 954 citations

Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial

2006 • 926 citations

Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial

2003 • 893 citations

The safety of statins in clinical practice

2007 • 830 citations

Meta-Analysis of Cardiovascular Outcomes Trials Comparing Intensive Versus Moderate Statin Therapy

2006 • 776 citations

Fluvastatin for Prevention of Cardiac Events Following Successful First Percutaneous Coronary Intervention<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2002 • 710 citations

Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.

1991 • 550 citations

Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12 064 survivors of myocardial infarction: a double-blind randomised trial

2010 • 545 citations

Efficacy and Safety of Atorvastatin in the Prevention of Cardiovascular End Points in Subjects With Type 2 Diabetes

2006 • 540 citations

Treatment with Atorvastatin to the National Cholesterol Educational Program Goal Versus 'Usual' Care in Secondary Coronary Heart Disease Prevention

2002 • 537 citations

Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease

2007 • 501 citations

Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics

2004 • 288 citations

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial

2010 • 246 citations

Effect of the Magnitude of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer

2007 • 236 citations

Safety of Aggressive Lipid Management

2007 • 171 citations

The Efficacy and Six-Week Tolerability of Simvastatin 80 and 160 mg/Day

1997 • 168 citations

Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics: The ALLIANCE study

2005 • 118 citations

Benefits and Risks of HMG-CoA Reductase Inhibitors in the Prevention of Coronary Heart Disease A Reappraisal

1996 • 103 citations

Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens

1995 • 96 citations

Results of the low-dose (20 mg) pravastatin GISSI Prevenzione trial in 4271 patients with recent myocardial infarction: do stopped trials contribute to overall knowledge? GISSI Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico).

2000 • 45 citations

Early high-dose lipid-lowering therapy to avoid cardiac events: a systematic review and economic evaluation

2009 • 39 citations

Deleted Work

1955 • 0 citations