Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm

The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function

1999 • 2,843 citations

Amyotrophic lateral sclerosis

2009 • 850 citations

Newton—Raphson and EM Algorithms for Linear Mixed-Effects Models for Repeated-Measures Data

1988 • 845 citations

Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial

2007 • 625 citations

Sharing Health Data for Better Outcomes on PatientsLikeMe

2010 • 607 citations

Lithium delays progression of amyotrophic lateral sclerosis

2008 • 543 citations

Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues

2007 • 431 citations

Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

2002 • 404 citations

Minocycline delays disease onset and mortality in a transgenic model of ALS

2002 • 296 citations

Repurposing with a Difference

2009 • 220 citations

Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

2010 • 187 citations

Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis

2004 • 137 citations

Medicine on the Fringe: Stem Cell-Based Interventions in Advance of Evidence

2009 • 125 citations

Clinical significance in the change of decline in ALSFRS-R

2010 • 96 citations

Lithium carbonate in amyotrophic lateral sclerosis

2010 • 94 citations

Development and evaluation of a self-administered version of the ALSFRS-R

2006 • 82 citations

Toward more efficient clinical trials for amyotrophic lateral sclerosis

2009 • 80 citations

Defining Survival as an Outcome Measure in Amyotrophic Lateral Sclerosis

2009 • 49 citations

How the Social Web Supports patient experimentation with a new therapy: The demand for patient-controlled and patient-centered informatics.

2008 • 48 citations

Outcomes research in amyotrophic lateral sclerosis: Lessons learned from the amyotrophic lateral sclerosis clinical assessment, research, and education database

2009 • 48 citations

Evaluation of Self-Reported Progression and Correlation of Imatinib Dose to Survival in Patients with Metastatic Gastrointestinal Stromal Tumors: An Open Cohort Study

2009 • 12 citations

Lithium therapy in ALS

2008 • 11 citations

Unapproved drug use: compassionate or cause for concern?

2009 • 11 citations

Comments on Fornai et al. (PNAS/ Feb 2008)

2008 • 4 citations

ALSUntangled No. 8: Low dose naltrexone for ALS

2010 • 3 citations