Approximate methods for estimating the pattern of nucleotide substitution and the variation of substitution rates among sites

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

Evolution of Protein Molecules

1969 • 11,042 citations

Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.

1993 • 10,775 citations

The rapid generation of mutation data matrices from protein sequences

1992 • 6,766 citations

Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology

1971 • 6,301 citations

The general stochastic model of nucleotide substitution

1990 • 2,350 citations

Univariate Discrete Distributions

2006 • 2,155 citations

Mitochondrial DNA sequences of primates: Tempo and mode of evolution

1982 • 1,578 citations

African Populations and the Evolution of Human Mitochondrial DNA

1991 • 1,320 citations

Estimating the pattern of nucleotide substitution

1994 • 1,083 citations

Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites.

1993 • 1,064 citations

A simulation comparison of phylogeny algorithms under equal and unequal evolutionary rates.

1994 • 869 citations

Monophyletic Origins of the Metazoa: an Evolutionary Link with Fungi

1993 • 673 citations

Estimation of evolutionary distances between nucleotide sequences

1994 • 476 citations

Patterns of nucleotide substitution in pseudogenes and functional genes

1982 • 460 citations

Reconstructing evolutionary trees from DNA and proteinsequences: paralinear distances.

1994 • 443 citations

Comparison of models for nucleotide substitution used in maximum-likelihood phylogenetic estimation.

1994 • 437 citations

A space-time process model for the evolution of DNA sequences.

1995 • 409 citations

Mitochondrial cytochrome b: evolution and structure of the protein

1993 • 394 citations

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

1984 • 369 citations

Limitations of the evolutionary parsimony method of phylogenetic analysis.

1990 • 358 citations

Recovering a tree from the leaf colourations it generates under a Markov model

1994 • 332 citations

Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA

1993 • 307 citations

Minimum Mutation Fits to a Given Tree

1973 • 273 citations

Relative efficiencies of the maximum-likelihood, neighbor-joining, and maximum-parsimony methods when substitution rate varies with site.

1994 • 256 citations

Univariate Discrete Distributions (2nd Ed.)

1994 • 211 citations

Among-site rate variation and phylogenetic analysis of 12S rRNA in sigmodontine rodents.

1995 • 179 citations

Sequence Evolution of Mitochondrial DNA in Humans and Chimpanzees: Control Region and a Protein-Coding Region

1991 • 171 citations

Substitution-rate variation among sites and the estimation of transition bias.

1994 • 166 citations

Compositional Bias, Character-State Bias, and Character-State Reconstruction Using Parsimony

1994 • 156 citations

RATES OF MOLECULAR EVOLUTION

1986 • 137 citations

Estimates of DNA and protein sequence divergence: an examination of some assumptions.

1984 • 122 citations

Unequal Base Frequencies and the Estimation of Substitution Rates

1995 • 100 citations

Improved dating of the human/chimpanzee separation in the mitochondrial DNA tree: Heterogeneity among amino acid sites

1995 • 94 citations

Unbiased estimates of the number of nucleotide substitutions when substitution rate varies among different sites

1994 • 86 citations

Unbiased estimation of evolutionary distance between nucleotide sequences.

1993 • 83 citations

Patterns of ribosomal RNA evolution in salamanders.

1989 • 83 citations

Mixed Model Analysis of DNA Sequence Evolution

1995 • 81 citations

Evolution of Life: fossils, molecules, and culture

1991 • 81 citations

The spatial distribution of fixed mutations within genes coding for proteins

1983 • 60 citations

On the general reversible Markov process model of nucleotide substitution: A reply to Saccone et al.

1995 • 28 citations

Patterns of nucleotide substitutions inferred from the phylogenies of the class I major histocompatibility complex genes

1992 • 28 citations

Molecular evolutionary rates of oncogenes

1987 • 27 citations

Mutation pattern of human immunodeficiency virus genes

1991 • 27 citations

Overdispersed molecular clock at the major histocompatibility complex loci

1991 • 21 citations