Removal of sodium channel inactivation in squid giant axons by n-bromoacetamide.

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The action of calcium on the electrical properties of squid axons

1957 • 1,853 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

Chemical Modification of Proteins

2012 • 1,097 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Nonenzymatic Cleavage of Peptide Bonds: The Methionine Residues in Bovine Pancreatic Ribonuclease

1962 • 929 citations

Chemicals as tools in the study of excitable membranes.

1974 • 918 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Charges and Potentials at the Nerve Surface

1968 • 567 citations

Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase

1973 • 540 citations

[58] Determination of the tryptophan content of proteins with N-bromosuccinimide

1967 • 481 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

N-Acetylimidazole: A Reagent for Determination of “Free” Tyrosyl Residues of Proteins^*

1965 • 335 citations

An improved vaseline gap voltage clamp for skeletal muscle fibers.

1976 • 315 citations

Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance.

1978 • 263 citations

Sulfenyl halides as modifying reagents for polypeptides and proteins. I. Modification of tryptophan residues

1968 • 225 citations

An Environmentally-Sensitive Reagent with Selectivity for the Tryptophan Residue in Proteins

1964 • 167 citations

Replacement of the Protoplasm of a Giant Nerve Fibre with Artificial Solutions

1961 • 164 citations

The Effects of External Potassium and Long Duration Voltage Conditioning on the Amplitude of Sodium Currents in the Giant Axon of the Squid, Loligo pealei

1969 • 158 citations

Destruction of the sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo.

1976 • 155 citations

Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation.

1976 • 133 citations

[30] N-Bromosuccinimide cleavage of peptides

1967 • 123 citations

Mechanism of negative temperature coefficient of nerve blocking action of allethrin.

1972 • 117 citations

Slow changes in membrane permeability and long‐lasting action potentials in axons perfused with fluoride solutions

1970 • 115 citations

Ionic Conductance Changes in Voltage Clamped Crayfish Axons at Low pH

1974 • 103 citations

Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve

1976 • 100 citations

Condylactis Toxin: Interaction with Nerve Membrane Ionic Conductances

1969 • 91 citations

EFFECTS OF VARIOUS POTASSIUM SALTS AND PROTEASES UPON EXCITABILITY OF INTRACELLULARLY PERFUSED SQUID GIANT AXONS

1964 • 88 citations

Sodium Conductance Activation without Inactivation in Pronase-perfused Axons

1971 • 79 citations

Acetylcarboxypeptidase^*

1963 • 76 citations

Effects of Redox and Sulfhydryl Reagents on the Bioelectric Properties of the Giant Axon of the Squid

1966 • 75 citations

The Influence of External Potassium on the Inactivation of Sodium Currents in the Giant Axon of the Squid, Loligo pealei

1969 • 74 citations

Mechanism of action of propranolol on squid axon membranes.

1973 • 69 citations

Effects of sulfhydryl blockade on axonal function

1958 • 67 citations

Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state

1976 • 62 citations

The interactions of calcium with mpyxicola giant axons and a description in terms of a simple surface charge model.

1975 • 61 citations

CURRENTS ASSOCIATED WITH THE IONIC GATING STRUCTURES IN NERVE MEMBRANE^fn1

1975 • 57 citations

Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents.

1977 • 56 citations

Isolation and Characterization of Active Fragments Obtained by Cleavage of Immunoglobulin G with Cyanogen Bromide

1966 • 49 citations

Intraaxonal iodate inhibits sodium inactivation

1974 • 49 citations

Selective modification of sodium channel gating in lobster axons by 2, 4, 6-trinitrophenol: Evidence for two inactivation mechanisms.

1975 • 47 citations

The determination of organic compounds with N-Bromosuccinimide and allied reagents

1975 • 44 citations

Morphology and Electrophysiological Properties of Squid Giant Axons Perfused Intracellularly with Protease Solution

1969 • 43 citations

Internal perfusion of crayfish giant axons: Action of tannic acid, DDT, and tea

1969 • 39 citations

Selective blocking of the nodal sodium channels by ultraviolet radiation

1974 • 38 citations

Ultraviolet photoalteration of ion channels in voltage-clamped lobster giant axons

1975 • 34 citations

The effect of electrical stimulation on the action of sulfhydryl reagents in the giant axon of squid; Suggested mechanisms for the role of thiol and disulfide groups in electrically-induced conformational changes

1974 • 34 citations

SPECIFIC CHEMICAL GROUPS INVOLVED IN THE CONTROL OF IONIC CONDUCTANCE IN NERVE^fn1

1975 • 28 citations

Release of proteins from the inner surface of squid axon membrane labeled with tritiated N-ethylmaleimide.

1976 • 28 citations

Effect of several “specific” chemical reagents on the Na+, K+ and leakage currents in voltage-clamped single nodes of ranvier

1974 • 27 citations

Effects of proteolytic enzymes on ionic conductances of squid axon membranes

1975 • 26 citations

Depolarization-induced change in the enzymatic radio-iodination of a protein on the internal surface of the squid giant axon membrane

1974 • 17 citations

Observations of sodium channel activation gating in squid axons internally perfused with pronase or N bromoacetamide

1977 • 3 citations

Condylactis toxin: interaction with nerve membrane ionic conductances

1969 • 2 citations

Pancuronium block of Na channels of squid axon membranes treated with pronase or N bromoacetamide

1977 • 1 citations

Deleted Work

1955 • 0 citations