Discrimination between Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging by Using Automated Segmentation of the Hippocampus

An Introduction to the Bootstrap

1994 • 39,661 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Voxel-Based Morphometry—The Methods

2000 • 8,281 citations

Whole Brain Segmentation

2002 • 8,116 citations

Mild cognitive impairment as a diagnostic entity

2004 • 7,048 citations

Unified segmentation

2005 • 6,816 citations

Global prevalence of dementia: a Delphi consensus study

2005 • 5,214 citations

Current Concepts in Mild Cognitive Impairment

2001 • 4,609 citations

Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

2004 • 4,596 citations

Staging of alzheimer's disease-related neurofibrillary changes

1995 • 2,187 citations

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1999 • 1,384 citations

Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

1997 • 1,067 citations

MR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease

1992 • 848 citations

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease

1999 • 777 citations

Hippocampal and entorhinal atrophy in mild cognitive impairment

2007 • 723 citations

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

2001 • 706 citations

In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease

2001 • 664 citations

Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease

1998 • 630 citations

Presymptomatic hippocampal atrophy in Alzheimer's disease

1996 • 630 citations

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

2003 • 617 citations

MRI measures of entorhinal cortex vs hippocampus in preclinical AD

2002 • 565 citations

Hippocampal formation glucose metabolism and volume losses in MCI and AD

2001 • 555 citations

Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study

2005 • 533 citations

Amnestic MCI or prodromal Alzheimer's disease?

2004 • 527 citations

Dementia of the Alzheimer Type

1980 • 518 citations

Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI

2005 • 482 citations

Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia

1996 • 438 citations

Elastic model-based segmentation of 3-D neuroradiological data sets

1999 • 435 citations

Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease

1997 • 412 citations

Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: Interobserver reliability

1995 • 397 citations

Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease

1993 • 376 citations

Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment

2002 • 363 citations

Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer’s disease☆

2000 • 346 citations

Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease

1988 • 340 citations

Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD

2000 • 320 citations

The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation.

1993 • 314 citations

Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease.

1994 • 302 citations

Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease

1999 • 274 citations

MRI of the Hippocampus in Alzheimer’s Disease: Sensitivity, Specificity, and Analysis of the Incorrectly Classified Subjects

1998 • 271 citations

Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus

2000 • 250 citations

Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease.

1999 • 212 citations

Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia

2002 • 210 citations

Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment

2005 • 205 citations

Qualitative Estimates of Medial Temporal Atrophy as a Predictor of Progression From Mild Cognitive Impairment to Dementia

2007 • 200 citations

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

2006 • 161 citations

Metaanalysis of Randomized Trials of the Efficacy and Safety of Donepezil, Galantamine, and Rivastigmine for the Treatment of Alzheimer Disease

2004 • 159 citations

The neural substrates of episodic memory impairment in Alzheimer’s disease as revealed by FDG–PET: relationship to degree of deterioration

2002 • 156 citations

Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta‐analysis of individual patient data from randomised controlled trials

2004 • 154 citations

Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer’s disease

2006 • 153 citations

Measuring Size and Shape of the Hippocampus in MR Images Using a Deformable Shape Model

2002 • 130 citations

Metaanalysis of Randomized Trials of the Efficacy and Safety of Donepezil, Galantamine, and Rivastigmine for the Treatment of Alzheimer Disease

2004 • 127 citations

Expert knowledge-guided segmentation system for brain MRI

2004 • 121 citations

3D image segmentation of deformable objects with joint shape-intensity prior models using level sets

2004 • 117 citations

Mesial Temporal Sclerosis and Temporal Lobe Epilepsy: MR Imaging Deformation-based Segmentation of the Hippocampus in Five Patients

2000 • 110 citations

Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment

2006 • 103 citations

Appearance-Based Segmentation of Medial Temporal Lobe Structures

2002 • 66 citations

Atrophy of the corpus callosum correlates with white matter lesions in patients with cerebral ischaemia

2000 • 42 citations