Epidemiologic and clinical aspects of insulin resistance and hyperinsulinemia

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

Blood pressure, stroke, and coronary heart disease

1990 • 4,424 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

A Comparison of the Effects of Hydrochlorothiazide and Captopril on Glucose and Lipid Metabolism in Patients with Hypertension

1989 • 870 citations

Risk Factors for Coronary Artery Disease in Healthy Persons with Hyperinsulinemia and Normal Glucose Tolerance

1989 • 792 citations

Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

1979 • 779 citations

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

1980 • 754 citations

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

1979 • 746 citations

Influence of body fat distribution on free fatty acid metabolism in obesity.

1989 • 676 citations

The effect of insulin on renal sodium metabolism

1981 • 633 citations

The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents

1989 • 622 citations

PHYSICAL ACTIVITY AND INCIDENCE OF HYPERTENSION IN COLLEGE ALUMNI

1983 • 596 citations

Insulin resistance is a characteristic feature of primary hypertension independent of obesity

1990 • 535 citations

Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Moderate Hypertension.

1981 • 530 citations

Effects of Weight Reduction on Obesity STUDIES OF LIPID AND CARBOHYDRATE METABOLISM IN NORMAL AND HYPERLIPOPROTEINEMIC SUBJECTS

1974 • 520 citations

Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT

1986 • 514 citations

High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study.

1988 • 446 citations

Resistance to Insulin-Stimulated-Glucose Uptake in Patients with Hypertension*

1988 • 433 citations

Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension

1988 • 359 citations

Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients.

1989 • 349 citations

Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1

1990 • 340 citations

Insulin Resistance, Glucose Intolerance and Hyperinsulinemia in Patients with Hypertension

1989 • 323 citations

Hyperinsulinemia in a Population at High Risk for Non-Insulin-Dependent Diabetes Mellitus

1986 • 311 citations

Elevated fibrinogen and plasminogen activator inhibitor (PAI‐1) in hypertension are related to metabolic risk factors for cardiovascular disease

1990 • 309 citations

Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2

1988 • 303 citations

Blood pressure (systolic and diastolic) and risk of fatal coronary heart disease.

1989 • 288 citations

The effect of physical training on insulin production in obesity

1970 • 282 citations

Smoking and Myocardial Infarction

1977 • 280 citations

Regional differences in the control of lipolysis in human adipose tissue

1979 • 278 citations

Insulin and renal sodium retention in obese adolescents.

1989 • 274 citations

Evidence for an Association of High Blood Pressure and Hyperinsulinemia in Obese Man

1986 • 256 citations

Effect of insulin on growth of cultured human arterial smooth muscle cells

1981 • 209 citations

Hyperglycemia and Glycosuria Due to Thiazide Derivatives Administered in Diabetes Mellitus

1960 • 208 citations

Obesity, Metabolism, and the Sympathetic Nervous System

1989 • 207 citations

Glucose Intolerance During Decreased Physical Activity in Man

1972 • 195 citations

Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

1989 • 184 citations

Postprandial hyperinsulinemia in patients with mild essential hypertension.

1985 • 166 citations

Effect of adrenergic-blocking or -stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man

1971 • 156 citations

ADVERSE REACTIONS TO BENDROFLUAZIDE AND PROPRANOLOL FOR THE TREATMENT OF MILD HYPERTENSION

1981 • 155 citations

DETERIORATION OF GLUCOSE TOLERANCE IN HYPERTENSIVE PATIENTS ON PROLONGED DIURETIC TREATMENT

1976 • 152 citations

Atherosclerosis in diabetes: The role of hyperinsulinemia

1988 • 151 citations

Captopril enhances insulin responsiveness of forearm muscle tissue in non‐insulin‐dependent diabetes mellitus

1987 • 148 citations

Blood pressure, insulin, and glycemia in nondiabetic subjects

1986 • 131 citations

Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man.

1984 • 118 citations

Chronic hyperinsulinemia and blood pressure regulation

1990 • 114 citations

EFFECT OF ADRENERGIC BLOCKING AGENTS ON INSULIN RESPONSE TO GLUCOSE INFUSION IN MAN

1972 • 104 citations

Hyperinsulinemia is characterized by jointly disturbed plasma VLDL, LDL, and HDL levels. A population-based study.

1988 • 96 citations

Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution

1989 • 93 citations

Differences in Metabolic Responses to β‐Adrenergic Stimulation after Propranolol or Metoprolol Administration

1979 • 85 citations

Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension

1989 • 77 citations

Mechanism of insulin action on resting membrane potential of frog skeletal muscle

1979 • 72 citations

The Prospective Cardiovascular Münster study: Prevalence and prognostic significance of hyperlipidemia in men with systemic hypertension

1987 • 67 citations

Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio

1990 • 65 citations

Hypertension and Diabetes

1988 • 64 citations

Impaired calcium metabolism associated with hypertension in Zucker obese rats

1990 • 63 citations

Metabolic Effects of Hydrochlorothiazide and Enalapril During Treatment of the Hypertensive Diabetic Patient

1988 • 62 citations

Insulin resistance and hypertension

1990 • 55 citations

Ca2+-Mg2+-ATPase activity of human red blood cells in healthy and diabetic volunteers

1987 • 54 citations

Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio

1990 • 49 citations

The effect of insulin deficiency on the metabolism of lipid emulsion models of triacylglycerol-rich lipoproteins in rats

1990 • 48 citations

Clinical Implications of Hypertension in the Diabetic Patient

1990 • 46 citations

Insulin resistance, obesity and hypertension.

1995 • 24 citations

Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients

1984 • 24 citations

Abnormal Ca²⁺-ATPase Activity in Erythrocytes of Non-Insulin-Dependent Diabetic Rats

1990 • 23 citations

Hyperinsulinemia as a possible etiology for the high prevalence of non insulin dependent diabetes in Mexican Americans.

1987 • 22 citations

A Trial of the Calcium Antagonist Nisoldipine in Hypertensive Non‐insulin‐dependent Diabetic Patients

1986 • 17 citations

Relationship between hypertension and subtle and overt abnormalities of carbohydrate metabolism.

1990 • 12 citations

Glucose metabolism during long-term treatment with prazosin.

1985 • 9 citations

Insulin sensitivity in humans: alterations during drug administration and in essential hypertension.

1990 • 5 citations

Deleted Work

1955 • 0 citations