Health benefits of probiotics: are mixtures more effective than single strains?

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

2000 • 1,505 citations

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial

2003 • 1,139 citations

Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus

1994 • 998 citations

Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis

2003 • 905 citations

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

2005 • 723 citations

Effect of probiotic Lactobacillus strains in children with atopic dermatitis

2003 • 608 citations

Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial

2007 • 586 citations

Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis

1999 • 572 citations

Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double‐blind placebo‐controlled trial

2004 • 473 citations

A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome

2003 • 469 citations

Pouchitis following heal pouch-anal anastomosis: Definition, pathogenesis, and treatment

1994 • 428 citations

Meta-analysis of probiotics for the prevention of traveler's diarrhea

2005 • 399 citations

A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating

2005 • 392 citations

The mechanism of action of probiotics

2007 • 369 citations

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention

2005 • 365 citations

Epidemiology of Clostridium difficile-associated infections

2001 • 357 citations

Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota

2007 • 354 citations

Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study

2002 • 326 citations

Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis

1994 • 298 citations

The placebo effect in irritable bowel syndrome trials: a meta‐analysis¹

2005 • 274 citations

Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea.

2004 • 253 citations

Bacterial supplementation in the irritable bowel syndrome. A randomised doubleblind placebo-controlled crossover study

2000 • 245 citations

Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease.

1997 • 224 citations

Review article: proton pump inhibitors and bacterial overgrowth

2005 • 221 citations

Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea

2002 • 212 citations

Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

2006 • 205 citations

Effects of probiotic on intestinal mucosa of patients with ulcerative colitis

2004 • 199 citations

The Effect of Exogenous Administration ofLactobacillus reuteriR2LC and Oat Fiber on Acetic Acid-Induced Colitis in the Rat

1993 • 196 citations

Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci)

2003 • 195 citations

Probiotic supplementation improves tolerance to <scp>Helicobacter pylori</scp> eradication therapy – a placebo‐controlled, double‐blind randomized pilot study

2005 • 194 citations

Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children

2010 • 193 citations

Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea

2001 • 190 citations

Effect of Probiotics on Constipation, Fecal Azoreductase Activity and Fecal Mucin Content in the Elderly

2002 • 188 citations

Assessment of adhesion properties of novel probiotic strains to human intestinal mucus

2001 • 184 citations

Prophylaxis against ampicillin-associated diarrhea with a lactobacillus preparation

1979 • 182 citations

Probiotic bacteriaBifidobacterium animalisMB5 andLactobacillus rhamnosusGG protect intestinal Caco-2 cells from the inflammation-associated response induced by enterotoxigenicEscherichia coliK88

2006 • 179 citations

Treatment and prevention of antibiotic associated diarrhea

2000 • 176 citations

Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants

2005 • 172 citations

Inhibition of in vitro growth of enteropathogens by new Lactobacillus isolates of human intestinal origin

2006 • 160 citations

Reduction of fecal shedding of enterohemorrhagic Escherichia coli O157:H7 in lambs by feeding microbial feed supplement

2001 • 143 citations

Prevention of gastrointestinal infection using immunobiological methods with milk fermented withLactobacillus caseiandLactobacillus acidophilus

1990 • 141 citations

Variable Response to Probiotics in Two Models of Experimental Colitis in Rats

2002 • 131 citations

Treatment of acute otitis media with probiotics in otitis-prone children—A double-blind, placebo-controlled randomised study

2007 • 121 citations

Oral administration of two probiotic strains, Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711, enhances the intestinal function of healthy adults

2005 • 118 citations

The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans.

2006 • 117 citations

Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters

2005 • 115 citations

Current level of consensus on probiotic science-Report of an expert meeting- London, 23 November 2009

2010 • 111 citations

Development of New Probiotics by Strain Combinations: Is It Possible to Improve the Adhesion to Intestinal Mucus?

2007 • 108 citations

Protection mechanism of probiotic combination against human pathogens: in vitro adhesion to human intestinal mucus.

2006 • 102 citations

Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome1–3

2010 • 100 citations

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

2007 • 95 citations

The epidemiology of rotavirus diarrhea in Latin America: anticipating rotavirus vaccines

2004 • 94 citations

Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study

2008 • 83 citations

Specific probiotic strains and their combinations counteract adhesion ofEnterobacter sakazakiito intestinal mucus

2008 • 80 citations

Effects of Multispecies Probiotic Combination on Helicobacter pylori Infection In Vitro

2008 • 74 citations

Effect of supplements with lactic acid bacteria and oligofructose on the intestinal microflora during administration of cefpodoxime proxetil

2000 • 70 citations

Interaction of Antimicrobial Therapy and Intestinal Flora

1970 • 67 citations

Modulation of the intestinal ecosystem by probiotics and lactulose in children during treatment with ceftriaxone

2001 • 59 citations

Antimicrobial activity of a multispecies probiotic (Ecologic 641) against pathogens isolated from infected pancreatic necrosis

2007 • 55 citations

In vitro studies on the inhibition of the growth of Shigella sonnei by Lactobacillus casei and Lact. acidophilus

1992 • 46 citations

Enhancement of host resistance against Salmonella typhimurium in mice fed a diet supplemented with yogurt or milks fermented with various Lactobacillus casei strains

1995 • 41 citations

Atopic eczema/dermatitis syndrome – a genetically complex disease. New advances in discovering the genetic contribution

2003 • 31 citations

Oral supplementation with lactic acid-producing bacteria during intake of clindamycin

1997 • 30 citations

Comparative efficacy of dioctahedral smectite (Smecta®) and a probiotic preparation in chronic functional diarrhoea

2004 • 29 citations

Replacement of intravenous therapy by oral rehydration solution in a large treatment centre for diarrhoea with dehydration.

1983 • 24 citations

Comparison of three probiotics in the treatment of acute diarrhea in mentally retarded children.

2000 • 18 citations