Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITY

1975 • 855 citations

Effects of Adenosine Nucleosides on Adenylate Cyclase, Phosphodiesterase, Cyclic Adenosine Monophosphate Accumulation, and Lipolysis in Fat Cells

1972 • 321 citations

Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

1974 • 298 citations

Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase

1973 • 271 citations

Adenosine Inhibition of Lymphocyte-Mediated Cytolysis: Possible Role of Cyclic Adenosine Monophosphate

1975 • 265 citations

Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane

1974 • 224 citations

The rapid induction by phytohemagglutinin of increased α-aminoisobutyric acid uptake by lymphocytes

1971 • 222 citations

Regulation of the synthesis of 5-phosphoribosyl-i-pyrophosphate in intact red blood cells and in cell-free preparations

1969 • 204 citations

Adenosine deaminase from human erythrocytes: Purification and effects of adenosine analogs

1975 • 204 citations

Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis.

1976 • 182 citations

Rate-limiting steps in the interconversion of purine ribonucleotides in Ehrlich ascites tumor cells in vitro.

1971 • 173 citations

Purification and Properties of Adenosine Kinase from Human Tumor Cells of Type H. Ep. No. 2

1967 • 171 citations

Synthesis of 5-Phosphoribosyl 1-Pyrophosphate from Glucose in Ehrlich Ascites Tumor Cells in Vitro

1965 • 157 citations

Effect of Cyclic 3',5'-Adenosine Monophosphate and Theophylline on Lymphocyte Transformation

1970 • 157 citations

Effect of Phytohemagglutinin on Lymphocyte Membrane Transport

1971 • 155 citations

Mediated Transport of Nucleosides in Human Erythrocytes

1972 • 146 citations

Nucleoside Transport. II. Inhibition by p-Nitrobenzylthioguanosine and Related Compounds

1971 • 118 citations

Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.

1973 • 111 citations

Adenosine metabolism in human erythrocytes

1971 • 106 citations

Alternative Pathways of Deoxyadenosine and Adenosine Metabolism

1973 • 99 citations

Partial purification and properties of the common inherited forms of adenosine deaminase from human erythrocytes

1973 • 99 citations

Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro

1967 • 96 citations

Appearance of Hydrolase Rich Granules in Human Lymphocytes Induced by Phytohemagglutinin and Antigens

1967 • 86 citations

Combined Immunodeficiency Disease and Adenosine Deaminase Deficiency. A Molecular Defect

1976 • 85 citations

On the Mechanism of Adenyl Cyclase Inhibition by Adenosine

1973 • 77 citations

Control Mechanisms of Adenine Nucleotide Metabolism of Ascites Tumor Cells

1971 • 74 citations

Serum Adenosine Deaminase: Methodology and Clinical Applications

1962 • 72 citations

Enhanced Effects of Prostaglandin E1 and Dibutyryl Cyclic AMP upon Human Lymphocytes in the Presence of Cortisol

1973 • 71 citations

Detection of the Carrier State in Combined Immunodeficiency Disease Associated with Adenosine Deaminase Deficiency

1974 • 69 citations

Absence of erythrocyte adenosine deaminase associated with severe combined immunodeficiency

1974 • 67 citations

ADENOSINE DEAMINASE ACTIVITY IN LYMPHOID CELLS DURING ANTIBODY PRODUCTION

1963 • 66 citations

Evidence for Control of Several Different Tissue-specific Isozymes of Adenosine Deaminase by a le Genetic Locus

1973 • 65 citations

Synthesis of coformycin

1974 • 63 citations

Control of Pyrimidine Biosynthesis in Human Lymphocytes

1971 • 55 citations

Alterations in isozymes of adenosine deaminase during stimulation of human peripheral blood lymphocytes

1974 • 53 citations

Divergent action of cAMP and dibutyryl cAMP on macromolecular synthesis in HeLa S3 cultures

1972 • 51 citations

Divergent action mechanism of cAMP and dibutyryl cAMP on cell proliferation and macromolecular synthesis in HeLa S3 cultures

1973 • 45 citations

Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture

1969 • 42 citations

Adenosine formation and metabolism during adenosine triphosphate catabolism in Ehrlich ascites tumor cells.

1973 • 40 citations

Control of Pyrimidine Biosynthesis in Human Lymphocytes

1973 • 40 citations

Decreased lymphocyte adenosine deaminase activity in acute lymphocytic leukemia children and their parents.

1975 • 34 citations

Studies of the Regulation of Purine Nucleotide Catabolism

1975 • 29 citations

A GENERAL METHOD OF PURIFICATION OF ADENOSINE DEAMINASE BY AFFINITY CHROMATOGRAPHY

1975 • 29 citations

Comparative studies of human adenosine deaminases

1975 • 29 citations

Levels of nucleoside and nucleotide kinases in Rhesus monkey tissues

1974 • 26 citations

A kinetic analysis of purine nucleotide synthesis and interconversion in intact Ehrlich ascites tumor cells

1973 • 24 citations

Phosphorylation of Adenosine and Deoxyadenosine in Ehrlich Ascites Carcinoma Cells Resistant to 6-(Methylmercapto)purine Ribonucleoside

1972 • 22 citations

Effect of lowered intracellular ATP and GTP concentrations on purine ribonucleotide synthesis and interconversion

1977 • 19 citations

Purine and Pyrimidine Pool Sizes and Purine Base Utilization in Human Lymphocytes and Cultured Lymphoblasts

1974 • 17 citations

Effects of Elevated Intracellular ATP and GTP Concentrations on Purine Ribonucleotide Synthesis and Interconversion

1973 • 17 citations

Incorporation of hypoxanthine by PHA-stimulated HPRT-deficient lymphocytes

1974 • 14 citations

Control of Pyrimidine Biosynthesis in Human Lymphocytes

1973 • 11 citations