Complementation of the xeroderma pigmentosum DNA repair synthesis defect withEscherichia coliUvrABC proteins in a cell-free system

Defective Repair Replication of DNA in Xeroderma Pigmentosum

1968 • 1,739 citations

Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases

1987 • 1,070 citations

DNA REPAIR ENZYMES

1988 • 822 citations

A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region

1983 • 618 citations

Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts

1988 • 448 citations

Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor That Binds to Damaged DNA

1988 • 417 citations

Acquired Precursors of Cutaneous Malignant Melanoma

1985 • 345 citations

[35] In Vitro transcription: Whole-cell extract

1983 • 311 citations

Xeroderma Pigmentosum: Variants with Normal Dna Repair and Normal Sensitivity to Ultraviolet Light

1972 • 244 citations

Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease.

1985 • 223 citations

Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complex.

1985 • 222 citations

Five complementation groups in xeroderma pigmentosum

1975 • 199 citations

DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum.

1976 • 176 citations

A seventh complementation group in excision-deficient xeroderma pigmentosum

1979 • 163 citations

Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts.

1988 • 152 citations

Human nucleotide excision repairin vitro: repair of pyrimidine dimers, psoralen and cisplatin adducts by HeLa cell-free extract

1989 • 141 citations

Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus

1978 • 131 citations

A sixth complementation group in xeroderma pigmentosum

1979 • 119 citations

Repair synthesis by human cell extracts in DNA damaged bycis- andtrans-diamminedichloroplatinum(II)

1989 • 113 citations

Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).

1985 • 108 citations

Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II)

1985 • 105 citations

Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)

1989 • 102 citations

Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.

1977 • 88 citations

Abnormal sensitivity to UV‐radiation in cultured skin ibroblasts from patients with hereditary cutaneous malignant melanoma and dysplastic nevus syndrome

1982 • 84 citations

Analysis of sequential steps of nucleotide excision repair in Escherichia coli using synthetic substrates containing single psoralen adducts.

1988 • 82 citations

Repair of pyrimidine dimer ultraviolet light photoproducts by human cell extracts

1989 • 78 citations

Bone metabolism of milk goats and sheep during second pregnancy and lactation in comparison to first lactation

2007 • 75 citations

Enzymatic repair of pyrimidine dimer-containing DNA. A 5' dimer DNA glycosylase: 3'-apyrimidinic endonuclease mechanism from Micrococcus luteus.

1982 • 71 citations

Hereditary dysplastic nevus syndrome: lymphoid cell ultraviolet hypermutability in association with increased melanoma susceptibility.

1986 • 69 citations

Stimulation of the UvrABC enzyme-catalyzed repair reactions by the UvrD protein (DNA helicase II)

1985 • 63 citations

Evidence that xeroderma pigmentosum cells from complementation group E are deficient in a homolog of yeast photolyase.

1989 • 62 citations

The purification of theEscherichia coliUvrABC incision system

1986 • 61 citations

Fibroblasts from patients with hereditary cutaneous malignant melanoma are abnormally sensitive to the mutagenic effect of simulated sunlight and 4-nitroquinoline 1-oxide.

1984 • 61 citations

Microinjection of Micrococcus luteus UV-endonuclease restores UV-induced unscheduled DNA synthesis in cells of 9 xeroderma pigmentosum complementation groups

1985 • 52 citations

IN VIVO EXCISION OF PYRIMIDINE DIMERS IS MEDIATED BY A DNA N‐GLYCOSYLASE IN MICROCOCCUS LUTEUS BUT NOT IN HUMAN FIBROBLASTS

1982 • 49 citations

Photoreversal: dependent release of thymidine and thymidine monophosphate from pyrimidine dimer containing DNA excision fragments isolated from ultraviolet-damaged human fibroblasts

1986 • 46 citations

Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma

1983 • 41 citations

Incision of damaged versus nondamaged DNA by theEscherichia coliUvrABC proteins

1988 • 39 citations

Xeroderma pigmentosum patients from the federal Republic of Germany: Decrease in post-UV colony-forming ability in 30 xeroderma pigmentosum fibroblast strains is quantitatively correlated with a decrease in DNA-incising capacity

1985 • 35 citations

DNA cross-linked by cisplatin: a new probe for the DNA repair defect in xeroderma pigmentosum.

1987 • 33 citations

Host-cell reactivation of cis-diamminedichloroplatinum(II)-treated SV40 DNA in normal human, Fanconi anaemia and xeroderma pigmentosum fibroblasts

1984 • 32 citations

Repair of trans-Pt(II)diamminedichloride DNA—protein crosslinks in normal and excision-deficient human cells

1982 • 24 citations

Microinjection of Escherichia coli UvrA, B, C and D proteins into fibroblasts of xeroderma pigmentosum complementation groups A and C does not result in restoration of UV-induced unscheduled DNA synthesis

1986 • 24 citations

Restoration of u.v.-induced excision repair in Xeroderma D cells transfected with the denV gene of bacteriophage T4.

1987 • 20 citations

Relationship between sensitivity of cells from patients with hereditary cutaneous malignant melanoma to killing and mutations by 4-nitroquinoline 1-oxide and adduct formation.

1988 • 14 citations

Evidence that Xeroderma Pigmentosum Cells from Complementation Group E Are Deficient in a Homolog of Yeast Photolyase

1989 • 14 citations

The expression of the Escherichia coli uvrA gene in human cells

1988 • 7 citations