Investigation of Folate Pathway Gene Polymorphisms and the Incidence of Neural Tube Defects in a Texas Hispanic Population

Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study

1991 • 3,323 citations

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

Prevention of neural tube defects: Results of the Medical Research Council vitamin study

1992 • 2,294 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

Prevention of Neural-Tube Defects with Folic Acid in China

1999 • 1,060 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects

1989 • 629 citations

FURTHER EXPERIENCE OF VITAMIN SUPPLEMENTATION FOR PREVENTION OF NEURAL TUBE DEFECT RECURRENCES

1983 • 504 citations

Periconceptional Use of Multivitamins and the Occurrence of Neural Tube Defects

1988 • 487 citations

Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.

1993 • 486 citations

Multivitamin/Folic Acid Supplementation in Early Pregnancy Reduces the Prevalence of Neural Tube Defects

1989 • 462 citations

Periconceptional Folic Acid Exposure and Risk of Occurrent Neural Tube Defects

1993 • 405 citations

Maternal hyperhomocysteinemia: A risk factor for neural-tube defects?

1994 • 402 citations

Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia

1989 • 353 citations

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

1997 • 346 citations

The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother

1999 • 248 citations

Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease

1997 • 195 citations

Maternal Vitamin Use, Genetic Variation of Infant Methylenetetrahydrofolate Reducatase, and Risk for spina Bifida

1998 • 156 citations

Decreased methylene tetrahydrofolate reductase activity due to the 677C→T mutation in families with spina bifida offspring

1996 • 154 citations

Neural Tube Defects along the Texas-Mexico Border, 1993-1995

1999 • 137 citations

Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects

1997 • 98 citations

Analysis of select folate pathway genes,PAX3, and humanT in a midwestern neural tube defect population

1999 • 97 citations

Neural Tube and Craniofacial Defects With Special Emphasis On Folate Pathway Genes

1998 • 92 citations

Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population

1998 • 89 citations

Lack of association between mutations in the folate receptor-alpha gene and spina bifida.

1998 • 74 citations

Selective expression of the high-affinity isoform of the folate receptor (FR-α) in the human placental syncytiotrophoblast and choriocarcinoma cells

1994 • 62 citations

Lack of association between mutations in the folate receptor-? gene and spina bifida

1998 • 60 citations

N‐methyl‐D‐aspartate receptor agonists modulate homocysteine‐induced developmental abnormalities

1999 • 57 citations

Is mutated MTHFR a risk factor for neural tube defects?

1996 • 54 citations

Molecular genetic analysis of human folate receptors in neural tube defects

1999 • 53 citations

The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians

1997 • 50 citations

9 Effects of folate deficiency on embryonic development

1995 • 47 citations

Prevention of Neural-Tube Defects With Folic Acid in China

2000 • 45 citations

PATHOGENESIS OF SPINA BIFIDA

1969 • 33 citations

Folates and the fetus

1997 • 30 citations

Recent developments in the understanding of the aetiology of neural tube defects

1995 • 25 citations