Rat hepatic stellate cell expression of α2-macroglobulin is a feature of cellular activation: implications for matrix remodelling in hepatic fibrosis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring

1995 • 1,166 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

1990 • 742 citations

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

1996 • 485 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver

1985 • 259 citations

Primary structure of human alpha 2-macroglobulin. V. The complete structure.

1984 • 253 citations

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells.

1987 • 228 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

1989 • 177 citations

Human Fibroblast Collagenase-α-Macroglobulin Interactions

1989 • 164 citations

Regulation of acute phase gene expression by inflammatory mediators.

1987 • 136 citations

Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity

1992 • 131 citations

Tissue Inhibitor of Metalloproteinase-1 and Interstitial Collagenase Expression in Autoimmune Chronic Active Hepatitis and Activated Human Hepatic Lipocytes

1995 • 112 citations

Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis

1982 • 111 citations

Kupffer cell–derived 95-kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells

1995 • 109 citations

Immunogold quantitation of laminin, type IV collagen, and heparan sulfate proteoglycan in a variety of basement membranes.

1988 • 104 citations

The Plasminogen–Activating System in Hepatic Stellate Cells

1996 • 100 citations

Liver Collagenase in Murine Schistosomiasis

1980 • 89 citations

Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system.

1995 • 88 citations

Interaction of Human Rheumatoid Synovial Collagenase (Matrix Metalloproteinase 1) and Stromelysin (Matrix Metalloproteinase 3) with Human α2-Macroglobulin and Chicken Ovostatin

1989 • 87 citations

Collagenase in experimental carbon tetrachloride cirrhosis of the liver.

1978 • 87 citations

Alpha 2-macroglobulin and antithrombin-heparin cofactor: modulators of hemostatic and inflammatory reactions. Alpha 2-macroglobulin.

1976 • 74 citations

Matrix Degradation in the Liver

1990 • 73 citations

Direct measurement of neutral collagenase activity in homogenates from baboon and human liver

1981 • 47 citations

Cultured Ito cells of rat liver express the α₂‐macroglobulin gene

1987 • 45 citations

Inactivation of human interleukin-2 (IL-2) by alpha 2-macroglobulin-trypsin complexes.

1986 • 42 citations

Reversible inhibition of albumin production by rat hepatocytes maintained on a laminin-rich gel (Engelbreth-Holm-Swarm) in response to secretory products of Kupffer cells and cytokines

1992 • 42 citations

Activated α₂‐Macroglobulin Promotes Mitogenesis in Rat Vascular Smooth Muscle Cells by a Mechanism that is Independent of Growth‐Factor‐Carrier Activity

1995 • 32 citations

Granuloma collagenase and EDTA-sensitive neutral protease production in hepatic murine schistosomiasis

1981 • 29 citations

Detection of alpha 2-macroglobulin, alpha 1-protease inhibitor, and neutral protease-antiprotease complexes within liver granulomas of Schistosoma mansoni-infected mice.

1988 • 25 citations

Human liver fibroblast capacity for synthesizing interstitial collagenase in vitro.

1990 • 21 citations

Differences in the binding of transforming growth factor β1 to the acute-phase reactant and constitutively synthesized α-macroglobulins of rat

1995 • 18 citations

Radioimmunoassay of soluble and insoluble collagenases in fibrotic liver

1984 • 16 citations

Feedback Mechanisms between α₂M and TGFβ1 Reduce Extracellular Matrix Synthesis of Liver Fat‐Storing Cells

1994 • 4 citations