Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

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The embryonic cell lineage of the nematode Caenorhabditis elegans

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1991 • 3,108 citations

C. elegans: des neurones et des gènes

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Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

1992 • 2,719 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Myotonic Dystrophy Mutation: an Unstable CTG Repeat in the 3′ Untranslated region of the Gene

1992 • 1,609 citations

An Unstable Triplet Repeat in a Gene Related to Myotonic Muscular Dystrophy

1992 • 1,437 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

1995 • 896 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

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A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

[30] Prediction and analysis of coiled-coil structures

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A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites.

1992 • 487 citations

Receptor-coupled, Permeabilized Smooth Muscle

1989 • 429 citations

Caenorhabditis elegans morphogenesis: The role of the cytoskeleton in elongation of the embryo

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Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.

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GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

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Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions

1990 • 379 citations

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1991 • 371 citations

Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy

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CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice

1996 • 332 citations

G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle.

1991 • 319 citations

Differential localization of two myosins within nematode thick filaments

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Gene replacement in Dictyostelium: generation of myosin null mutants.

1989 • 299 citations

Some Observations On Moulting in Caenorhabditis Elegans

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Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

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Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

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The basal component of the nematode dense-body is vinculin

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Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle

1991 • 250 citations

Myosin light-chain phosphatase

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cot-1, a gene required for hyphal elongation in Neurospora crassa, encodes a protein kinase.

1992 • 235 citations

The cellular basis of epithelial morphogenesis. A review

1988 • 206 citations

Phosphorylation of the Large Subunit of Myosin Phosphatase and Inhibition of Phosphatase Activity

1996 • 197 citations

Regulation of cytoplasmic and smooth muscle myosin

1991 • 196 citations

The biochemical basis of the regulation of smooth-muscle contraction

1994 • 187 citations

Involvement of rho in GTPγS‐induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity

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Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

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Vinculin is essential for muscle function in the nematode.

1991 • 173 citations

Chapter 2 Mutagenesis

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Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes.

1991 • 143 citations

The genome of Caenorhabditis elegans.

1995 • 143 citations

GTP gamma S-dependent regulation of smooth muscle contractile elements

1992 • 139 citations

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

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The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Chapter 20 Transcription and Translation

1995 • 113 citations

Effects of guanosine nucleotides on skinned smooth muscle tissue of the rabbit mesenteric artery.

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Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans.

1988 • 100 citations

The Cellular Basis of Epithelial Morphogenesis

1986 • 94 citations

Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase.

1995 • 79 citations

The making of a fly leg: A model for epithelial morphogenesis

1995 • 73 citations

Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site.

1993 • 71 citations

The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation

1993 • 61 citations

Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans.

1990 • 57 citations

Stage-specific requirement for myosin II during Dictyostelium development

1994 • 45 citations

Essential genes in the hDf6 region of chromosome I in Caenorhabditis elegans.

1990 • 41 citations

The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development.

1994 • 38 citations

A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein.

1993 • 36 citations

Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border.

1993 • 25 citations

Myosin Light Chain Phosphatase

1996 • 15 citations