Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress.

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

1994 • 3,007 citations

Ischemic Cell Death in Brain Neurons

1999 • 2,974 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose

1984 • 1,697 citations

Brain Metabolism during Fasting*

1967 • 1,590 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle

1974 • 1,252 citations

Short-chain dehydrogenases/reductases (SDR)

1995 • 1,228 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

1996 • 521 citations

PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

1991 • 410 citations

An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

1997 • 368 citations

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

1995 • 358 citations

Neuronal Protection in Stroke by an sLe ^x -Glycosylated Complement Inhibitory Protein

1999 • 313 citations

High performance liquid chromatography: a rapid isocratic method for determination of creatine compounds and adenine nucleotides in myocardial tissue

1986 • 294 citations

d-β-Hydroxybutyric Dehydrogenase of Mitochondria

1960 • 290 citations

Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain

1990 • 259 citations

The Flux from Glucose to Glutamate in the Rat Brain in vivo as Determined by ¹-Observed, ¹³C-Edited NMR Spectroscopy

1990 • 249 citations

Procedural and Strain-related Variables Significantly Affect Outcome in a Murine Model of Focal Cerebral Ischemia

1996 • 220 citations

Exacerbation of Cerebral Injury in Mice That Express the P-Selectin Gene

1997 • 198 citations

Purification and Characterization of a Novel Stress Protein, the 150-kDa Oxygen-regulated Protein (ORP150), from Cultured Rat Astrocytes and Its Expression in Ischemic Mouse Brain

1996 • 194 citations

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

1999 • 189 citations

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1995 • 187 citations

Carbon flux through citric acid cycle pathways in perfused heart by ¹³C NMR spectroscopy

1987 • 161 citations

Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons

1997 • 161 citations

Genetic association of an ( 2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease

1998 • 161 citations

13C labeling in studies of metabolic regulation

1988 • 141 citations

Human Brain Short Chain l-3-Hydroxyacyl Coenzyme A Dehydrogenase Is a Single-domain Multifunctional Enzyme

1999 • 136 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

A Human Brain l-3-Hydroxyacyl-coenzyme A Dehydrogenase Is Identical to an Amyloid β-Peptide-binding Protein Involved in Alzheimer's Disease

1998 • 118 citations

CEREBRAL ARTERIO‐VENOUS DIFFERENCE OF ACETOACETATE AND D‐β‐HYDROXYBUTYRATE IN CHILDREN

1972 • 117 citations

Role of ERAB/l-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Aβ-induced Cytotoxicity

1999 • 113 citations

Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration

1995 • 112 citations

Glucose and glycogen utilisation in myocardial ischemia--changes in metabolism and consequences for the myocyte.

1998 • 110 citations

NMR Spectroscopic Studies of <sup>13</sup>C Acetate and <sup>13</sup>C Glucose Metabolism in Neocortical Astrocytes: Evidence for Mitochondrial Heterogeneity

1993 • 107 citations

Calculation of Absolute Metabolic Flux and the Elucidation of the Pathways of Glutamate Labeling in Perfused Rat Heart by 13C NMR Spectroscopy and Nonlinear Least Squares Analysis

1995 • 98 citations

Preparation of a homogeneous soluble D-beta-hydroxybutyrate apodehydrogenase from mitochondria.

1975 • 91 citations

Two Mitochondrial 3-Hydroxyacyl-CoA Dehydrogenases in Bovine Liver

1996 • 82 citations

Apolipoprotein E and ALzheimer's Disease: The Tip of the Susceptibility Iceberg

1998 • 82 citations

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

1999 • 69 citations

scully, an Essential Gene of Drosophila, is Homologous to Mammalian Mitochondrial Type II <scp>l</scp>-3-hydroxyacyl-CoA Dehydrogenase/Amyloid-β Peptide-binding Protein

1998 • 66 citations

THE OXIDATION OF KETONE BODIES BY MITOCHONDRIA FROM LIVER AND PERIPHERAL TISSUES

1957 • 60 citations

Fasting Plasma Levels of Glucose, Acetoacetate, D-β-Hydroxybutyrate, Glycerol, and Lactate in the Baboon Infant: Correlation with Cerebral Uptake of Substrates and Oxygen

1977 • 60 citations

Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria

1997 • 45 citations

Free radicals and disruption of neuronal ion homeostasis in AD: A role for amyloid β-peptide?

1995 • 44 citations

Effect of training on the activity of five muscle enzymes studied on elite cross‐country skiers

1999 • 43 citations

A luciferase-engineered cell line for study of cAMP regulation in endothelial cells

1998 • 35 citations

Sequestration of Amyloid β‐Peptide^a

1993 • 33 citations

Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria

1988 • 27 citations

Determination of Acetyl-CoA Enrichment in Rat Heart and Skeletal Muscle by1H Nuclear Magnetic Resonance Analysis of Glutamate in Tissue Extracts

1997 • 27 citations

Role of Genetics in Tests of Genotype, Status, and Disease Progression in Early-Onset Alzheimer’s Disease

1998 • 25 citations

Changes in Aerobic and Anaerobic ATP-Synthesizing Activities in Hypoxic Mouse Brain1

1988 • 20 citations

Induction of 72‐kDa Inducible Heat Shock Protein (HSP72) in Cultured Rat Astrocytes After Energy Depletion

1998 • 17 citations

Combined enzyme histochemical and ultrastructural study on cryostat sections of pig heart to detect early reperfusion damage after ischaemia

1995 • 8 citations