Induction of in vitro differentiation of mouse embryonal carcinoma (F9) cells by inhibitors of topoisomerases.

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

Hormonal induction of differentiation in teratocarcinoma stem cells: Generation of parietal endoderm by retinoic acid and dibutyryl cAMP

1980 • 803 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

1988 • 443 citations

Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm

1981 • 384 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

4′-Demethyl-epipodophyllotoxin thenylidene glucoside (VM 26), a podophyllum compound with a new mechanism of action

1970 • 130 citations

Induction of in vitro differentiation of mouse erythroleukemia cells by genistein, an inhibitor of tyrosine protein kinases.

1991 • 80 citations

Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells.

1989 • 79 citations

The molecular basis of drug-induced G2 arrest in mammalian cells

1980 • 75 citations

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

1988 • 72 citations

Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.

1989 • 69 citations

Induction of teratocarcinoma cell differentiation

1983 • 49 citations

Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin

1990 • 33 citations

Studies on differentiation inducing substances of animal cells. I. Differenol A, a differentiation inducing substance against mouse leukemia cells.

1981 • 25 citations

The chemistry of subterranean clover. 1. Isolation of formononetin and genistein.

1951 • 23 citations