PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

The Mechanisms of Action of PPARs

2002 • 2,544 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Biological Action of Leptin as an Angiogenic Factor

1998 • 1,390 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Macrophages and angiogenesis

1994 • 1,123 citations

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

2000 • 992 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

2002 • 955 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Clinical Application of Antiangiogenic Therapy: Microvessel Density, What It Does and Doesn't Tell Us

2002 • 794 citations

Mechanism of action of taxol

1992 • 730 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo

1999 • 527 citations

Modulation of Vascular Inflammation In Vitro and In Vivo by Peroxisome Proliferator–Activated Receptor-γ Activators

2000 • 504 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Maspin is an angiogenesis inhibitor

2000 • 463 citations

Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2

1999 • 440 citations

Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2

1996 • 387 citations

PPARγ Activation in Human Endothelial Cells Increases Plasminogen Activator Inhibitor Type-1 Expression

1999 • 370 citations

Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation

2000 • 360 citations

Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.

1999 • 317 citations

Metastatic Model for Human Prostate Cancer Using Orthotopic Implantation in Nude Mice

1992 • 310 citations

Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.

2001 • 304 citations

Angiogenesis-dependent diseases

2001 • 294 citations

Troponin I is present in human cartilage and inhibits angiogenesis

1999 • 221 citations

Ligands for Peroxisome Proliferator-Activated Receptor γ Inhibit Growth and Induce Apoptosis of Human Papillary Thyroid Carcinoma Cells

2001 • 220 citations

Transforming Growth Factor-α Prevents Detachment-induced Inhibition of c-Src Kinase Activity, Bcl-XLDown-regulation, and Apoptosis of Intestinal Epithelial Cells

2001 • 202 citations

Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization.

2000 • 180 citations

Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy.

2000 • 141 citations

The Chick Embryo Chorioallantoic Membrane as a Model for in vivo Research on Anti-Angiogenesis

2000 • 124 citations

Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP).

1994 • 89 citations

Role of Peroxisome Proliferator-Activated Receptor γ and Its Ligands in Non-Neoplastic and Neoplastic Human Urothelial Cells

2001 • 84 citations

Ligands for Peroxisome Proliferator-Activated Receptor Inhibit Growth and Induce Apoptosis of Human Papillary Thyroid Carcinoma Cells

2001 • 78 citations

Aquaporins and the respiratory system: advice for a lung investigator

2000 • 78 citations

PPARgamma ligands as modulators of inflammatory and catabolic responses in arthritis. An overview.

2002 • 78 citations

Magnitude of Peroxisome Proliferator-Activated Receptor-γ Activation is Associated with Important and Seemingly opposite Biological Responses in Breast Cancer Cells

2001 • 70 citations

Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer.

2001 • 54 citations

Systemic exposure to rosiglitazone is unaltered by food

1999 • 51 citations

Effects of Troglitazone and Pioglitazone on Cytokine-Mediated Endothelial Cell Proliferation In Vitro

1998 • 41 citations