Viral infection and the pathogenesis of dilated cardiomyopathy.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

Viral myocarditis. A review.

1980 • 810 citations

DETECTION OF COXSACKIE-B-VIRUS-SPECIFIC RNA SEQUENCES IN MYOCARDIAL BIOPSY SAMPLES FROM PATIENTS WITH MYOCARDITIS AND DILATED CARDIOMYOPATHY

1986 • 605 citations

Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation.

1992 • 458 citations

Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis

1989 • 344 citations

In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease.

1987 • 313 citations

Involvement of T Lymphocytes in the Pathogenesis of Coxsackie Virus B3 Heart Disease

1974 • 310 citations

Microvascular spasm in the cardiomyopathic Syrian hamster: a preventable cause of focal myocardial necrosis.

1982 • 295 citations

Antibodies to Coxsackie B viruses in congestive cardiomyopathy.

1979 • 244 citations

Coxsackievirus B-3 myocarditis in Balb/c mice. Evidence for autoimmunity to myocyte antigens.

1984 • 243 citations

Coxsackie B myopericarditis in adults

1970 • 220 citations

Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury.

1992 • 186 citations

Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.

1992 • 178 citations

Viral myocarditis: A paradigm for understanding the pathogenesis and treatment of dilated cardiomyopathy

1993 • 162 citations

Residual pathologic changes following murine coxsackie A and B myocarditis.

1969 • 153 citations

A search for the presence of the enteroviral capsid protein VP1 in pancreases of patients with Type 1 (insulin-dependent) diabetes and pancreases and hearts of infants who died of coxsackieviral myocarditis

1990 • 134 citations

Coxsackie B3 virus can replicate in cultured human foetal heart cells and is inhibited by interferon

1985 • 133 citations

CHRONIC RELAPSING PERICARDITIS AND DILATED CARDIOMYOPATHY: SEROLOGICAL EVIDENCE OF PERSISTENT ENTEROVIRUS INFECTION

1989 • 124 citations

Idiopathic Cardiomyopathy A Study on the Infectious-Immune Theory as a Cause of the Disease

1971 • 123 citations

Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis.

1986 • 121 citations

Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

1987 • 120 citations

Detection of Coxsackievirus B3 RNA in myocardial tissues by the polymerase chain reaction.

1991 • 117 citations

The Role of Antibody and Host Cells in the Resistance of Mice Against Infection by Coxsackie B-3 Virus

1973 • 111 citations

Differential effects of myocarditic variants of Coxsackievirus B3 in inbred mice. A pathologic characterization of heart tissue damage.

1991 • 111 citations

Search for Coxsackievirus B3 RNA in idiopathic dilated cardiomyopathy using gene amplification by polymerase chain reaction

1992 • 109 citations

COXSACKIE-B-VIRUS-SPECIFIC IgM RESPONSES IN PATIENTS WITH CARDIAC AND OTHER DISEASES

1980 • 108 citations

A molecular and serologic evaluation of enteroviral involvement in human myocarditis

1990 • 106 citations

Clinical and experimental aspects of viral myocarditis

1989 • 96 citations

Detection of enteroviral RNA in idiopathic dilated cardiomyopathy and other human cardiac tissues.

1992 • 95 citations

Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value

1991 • 93 citations

Verapamil ameliorates the clinical and pathological course of murine myocarditis.

1992 • 88 citations

The Detection of Coxsackievirus RNA in Cardiac Tissue by in situ Hybridization

1988 • 84 citations

Routine use of μ‐antibody‐capture elisa for the serological diagnosis of coxsackie b virus infections

1986 • 83 citations

Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis.

1990 • 83 citations

Immune response to the endothelium in myocarditis, dilated cardiomyopathy and rejection after heart transplantation

1991 • 78 citations

Cardiac persistence of cardioviral RNA detected by polymerase chain reaction in a murine model of dilated cardiomyopathy.

1992 • 78 citations

Similar prevalence of enteroviral genome within the myocardium from patients with idiopathic dilated cardiomyopathy and controls by the polymerase chain reaction

1992 • 75 citations

Secondary enterovirus infection in the murine model of myocarditis. Pathologic and immunologic aspects.

1990 • 73 citations

Genomic Detection of Enteroviruses in The Myocardium. Studies on animal hearts with coxsackievirus B3 myocarditis and endomyocardial biopsies from patients with myocarditis and dilated cardiomyopathy.

1992 • 72 citations

A Mouse Model of Dilated-Type Cardiomyopathy Due to Coxsackievirus B3

1981 • 70 citations

Assessment of Cell-Mediated Hypersensitivity against Coxsackievirus B3 Viral-Induced Myocarditis Utilizing Hypertonic Salt Extracts of Cardiac Tissue

1978 • 70 citations

Coxsackievirus-B3-induced myocarditis: virus receptor antibodies modulate myocarditis.

1989 • 53 citations

Molecular studies on enteroviral heart disease: patterns of acute and persistent infections

1991 • 53 citations

Lack of Correlation between Neutralizing Antibody Production and Suppression of Coxsackievirus B-3 Replication in Target Organs: Evidence for Involvement of Mononuclear Inflammatory Cells in Host Defense

1979 • 53 citations

Isolation of a Coxsackie virus group B, type 5, from the heart of a fatal case of myocarditis in an adult

1969 • 48 citations

Coxsackievirus B3-induced myocarditis. Autoimmunity is L3T4+ T helper cell and IL-2 independent in BALB/c mice.

1987 • 45 citations

Anti-coxsackievirus B3 neutralizing antibodies with pathological potential

1991 • 41 citations

Fractionation and Immunologic Assessment of KCl-Extracted Cardiac Antigens in Coxsackievirus B3 Virus-Induced Myocarditis

1979 • 41 citations

Persistence of viral genome into late stages of murine myocarditis detected by polymerase chain reaction.

1992 • 41 citations

Failure to demonstrate enterovirus aetiology in Swedish patients with dilated cardiomyopathy

1993 • 38 citations

Quantitation of enteroviral RNA by competitive polymerase chain reaction

1993 • 37 citations

Progressive interstitial collagen deposition in Coxsackievirus B3-induced murine myocarditis.

1990 • 33 citations

Coxsackievirus B3 infection alters plasma membrane of neonatal skin fibroblasts

1986 • 33 citations

Coxsackie B3 Myocarditis in Athymic Mice

1981 • 32 citations

Coronary microvascular narrowing in acute murine coxsackie B3 myocarditis

1989 • 30 citations

FATAL MYOCARDITIS IN AN ADOLESCENT CAUSED BY COXSACKIE VIRUS, GROUP B, TYPE FOUR

1965 • 27 citations

Treatment of experimental murine coxsackie B3 myocarditis

1991 • 27 citations

Virological study of idiopathic cardiomyopathy. Serological study of virus antibodies and immunofluorescent study of myocardial biopsies.

1981 • 26 citations

The relationship of myocarditis to dilated cardiomyopathy

1984 • 23 citations

Molecular cloning of a heart antigen that cross-reacts with a neutralizing antibody to coxsackievirus B4

1991 • 18 citations

Natural history of coxsackievirus B3-induced myocarditis in ACA/Sn mice: viral persistence demonstrated by quantitative in situ hybridization histochemistry

1991 • 16 citations

Study of the Pericardium and Ventricular Myocardium

1963 • 14 citations

The value of endomyocardial biopsies in myocarditis and dilated cardiomyopathy

1991 • 13 citations

Experimental study of virus myocarditis in culture.

1979 • 10 citations

Influence of sex hormones on coxsackie virus group B, type 3 induced myocarditis in Balb/c mice

1987 • 10 citations

Mechanisms of group B coxsackie virus persistence in human cells

1987 • 8 citations

Deleted Work

1955 • 0 citations