Complex immunomodulatory effects of interferon‐β in multiple sclerosis include the upregulation of T helper 1‐associated marker genes

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Real time quantitative PCR.

1996 • 6,155 citations

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis

1998 • 2,049 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

1999 • 1,011 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

TNF neutralization in MS

1999 • 968 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Interferon beta‐lb in the treatment of multiple sclerosis

1995 • 899 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2

1996 • 715 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

1997 • 446 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Interferon beta in the treatment of multiple sclerosis

1998 • 340 citations

Tumor necrosis factor‐α messenger RNA expression in patients with relapsing‐remitting multiple sclerosis is associated with disease activity

1995 • 336 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

Association between clinical disease activity and Epstein–Barr virus reactivation in MS

2000 • 290 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis

1999 • 264 citations

The effect of interferon‐β on blood—brain barrier disruptions demonstrated by constrast‐enhanced magnetic resonance imaging in relapsing—remitting multiple sclerosis

1995 • 251 citations

Interferon beta induces interleukin‐10 expression: Relevance to multiple sclerosis

1996 • 240 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

The human intracellular Mx‐homologous protein is specifically induced by type I interferons

1990 • 161 citations

Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells

1999 • 103 citations

Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b

1995 • 100 citations

Type I interferons and T helper development

2000 • 98 citations

Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99)

1996 • 95 citations

Interferon responses of leukocytes in multiple sclerosis

1981 • 95 citations

Increased numbers of CCR5+ interferon-?- and tumor necrosis factor-?-secreting T lymphocytes in multiple sclerosis patients

2000 • 89 citations

Interferon beta results in immediate reduction of contrast‐enhanced MRI lesions in multiple sclerosis patients followed by weekly MRI

1997 • 78 citations

Diminished production of type-I interferons and interleukin-2 in patients with multiple sclerosis

1997 • 27 citations