Circadian Integration of Metabolism and Energetics

Hypothalamic regulation of sleep and circadian rhythms

2005 • 2,613 citations

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

2005 • 2,323 citations

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

2010 • 2,149 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Adverse metabolic and cardiovascular consequences of circadian misalignment

2009 • 2,029 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

The genetics of mammalian circadian order and disorder: implications for physiology and disease

2008 • 1,495 citations

Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage

2005 • 1,411 citations

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

2007 • 1,378 citations

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

2010 • 1,377 citations

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

2008 • 1,328 citations

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

2008 • 1,287 citations

Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

2009 • 1,094 citations

Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro

2005 • 1,037 citations

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

2009 • 1,034 citations

Physiological significance of a peripheral tissue circadian clock

2008 • 979 citations

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

2006 • 895 citations

Circadian Timing of Food Intake Contributes to Weight Gain

2009 • 882 citations

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

2009 • 862 citations

Slow-wave sleep and the risk of type 2 diabetes in humans

2008 • 856 citations

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

2010 • 835 citations

Harmonics of Circadian Gene Transcription in Mammals

2009 • 656 citations

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

2007 • 643 citations

Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

2007 • 607 citations

Abnormal Patterns of Insulin Secretion in Non-Insulin-Dependent Diabetes Mellitus

1988 • 565 citations

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

2007 • 526 citations

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

2010 • 504 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

NPAS2: A Gas-Responsive Transcription Factor

2002 • 422 citations

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

2009 • 421 citations

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

2009 • 399 citations

cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

2008 • 397 citations

Metabolism and the Control of Circadian Rhythms

2002 • 390 citations

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis

2009 • 379 citations

Circadian variation of blood pressure and the vascular response to asynchronous stress

2007 • 367 citations

The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

2002 • 344 citations

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

2010 • 334 citations

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

2010 • 321 citations

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

2008 • 275 citations

Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag

2010 • 266 citations

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

2009 • 259 citations

Vascular Disease in Mice With a Dysfunctional Circadian Clock

2009 • 257 citations

Network Features of the Mammalian Circadian Clock

2009 • 252 citations

The Cardiomyocyte Circadian Clock

2010 • 246 citations

Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

2010 • 205 citations

Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity

2007 • 204 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

2008 • 188 citations

Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

2010 • 162 citations

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

2009 • 155 citations

Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

2003 • 155 citations

A circadian-regulated gene, Nocturnin , promotes adipogenesis by stimulating PPAR-γ nuclear translocation

2010 • 141 citations

Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets

1998 • 140 citations

Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

2008 • 138 citations

Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice

2008 • 125 citations

The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake

2008 • 124 citations

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism

2008 • 123 citations

Circadian Control of the Daily Plasma Glucose Rhythm: An Interplay of GABA and Glutamate

2008 • 109 citations

Sleep and metabolism: shared circuits, new connections

2008 • 108 citations

Circadian regulation of islet genes involved in insulin production and secretion

2004 • 91 citations

Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.

1999 • 91 citations

Attenuating Effect of Clock Mutation on Triglyceride Contents in the ICR Mouse Liver under a High-Fat Diet

2007 • 76 citations

Induction of Circadian Gene Expression in Human Subcutaneous Adipose‐derived Stem Cells

2007 • 66 citations

Nocturnin Suppresses Igf1 Expression in Bone by Targeting the 3′ Untranslated Region of Igf1 mRNA

2010 • 43 citations

The liver-enriched transcription factor D-site-binding protein activates the promoter of the phosphoenolpyruvate carboxykinase gene in hepatoma cells.

1992 • 43 citations

Expression profile of mRNAs encoding core circadian regulatory proteins in human subcutaneous adipose tissue: correlation with age and body mass index

2009 • 26 citations

CIRCADIAN PATTERN OF AMBULATORY BLOOD PRESSURE IN UNTREATED HYPERTENSIVE PATIENTS WITH AND WITHOUT METABOLIC SYNDROME

2009 • 25 citations