Morphine, Morphine-3-Glucuronide, Morphine-6-Glucuronide, and 6-Monoacetylmorphine Determined by Means of Atmospheric Pressure Chemical Ionization-Mass Spectrometry-Liquid Chromatography in Body Fluids of Heroin Victims

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Morphine-3-glucuronide - a potent antagonist of morphine analgesia

1990 • 341 citations

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

1982 • 278 citations

The Pharmacokinetics of Heroin in Patients with Chronic Pain

1984 • 242 citations

Disposition of Heroin and Its Metabolites in Heroin-Related Deaths

1994 • 130 citations

Determination of morphine, morphine-6-glucuronide and normorphine in plasma and urine with high-performance liquid chromatography and electrochemical detection

1986 • 124 citations

An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites

1988 • 98 citations

Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum by solid-phase extraction and liquid chromatography-mass spectrometry with electrospray ionisation

1996 • 96 citations

Morphine‐6‐glucuronide Has High Affinity for the Opioid Receptor

1987 • 91 citations

Morphine and Morphine Glucuronides in Serum of Heroin Consumers and in Heroin-Related Deaths Determined by HPLC with Native Fluorescence Detection*

1995 • 89 citations

Morphine-6-Glucuronide might Mediate the Prolonged Opioid Effect of Morphine in Acute Renal Failure

1990 • 78 citations

Pharmacokinetics and pharmacodynamics of morphine‐3‐glucuronide in rats and its influence on the antinociceptive effect of morphine

1993 • 74 citations

High-performance liquid chromatographic-electrospray mass spectrometric determination of morphine and its 3- and 6-glucuronides: application to pharmacokinetic studies

1995 • 74 citations

Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain

1994 • 73 citations

Postmortem Distribution and Redistribution of Morphine in Man

1996 • 73 citations

A Simple, Rapid Method for the Simultaneous Determination of Morphine and Its Principal Metabolites in Plasma Using High-Performance Liquid Chromatography and Fluorometric Detection

1991 • 72 citations

Morphine and morphine-6-glucuronide plasma concentrations and effect in cancer pain

1996 • 68 citations

Analgesic response and plasma and brain extracellular fluid pharmacokinetics of morphine and morphine-6-beta-D-glucuronide in the rat.

1995 • 67 citations

Chronic morphine therapy for cancer pain

1991 • 63 citations

Gas chromatographic—mass spectrometric determination of morphine, codeine and 6-monoacetylmorphine in blood extracted by solid phase

1989 • 62 citations

Intrathecal morphine-3-glucuronide does not antagonize spinal antinociception by morphine or morphine-6-glucuronide in rats

1993 • 58 citations

Plasma Concentrations and Renal Clearance of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Cancer Patients Receiving Morphine

1993 • 50 citations

Morphine-3-glucuronide: Silent regulator of morphine actions

1994 • 47 citations

A Simplified Procedure for the Determination of Free Codeine, Free Morphine, and 6-Acetylmorphine in Urine

1992 • 47 citations

Computer-Assisted Interpretation in Forensic Toxicology: Morphine-Involved Deaths

1989 • 37 citations

A Highly Sensitive Assay for the Simultaneous Determination of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Human Plasma by High-Performance Liquid Chromatography with Electrochemical and

1996 • 36 citations

Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression.

1994 • 33 citations

Identification of Diacetylmorphine Metabolites in Humans

1977 • 33 citations

Sudden Death of a Heroin Body Packer

1985 • 32 citations

Solid phase extraction of morphine and its metabolites from postmortem blood

1996 • 29 citations

The Significance of Morphine Concentrations in the Cerebrospinal Fluid in Morphine Caused Deaths

1994 • 11 citations

Deleted Work

1955 • 0 citations