Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion

1994 • 863 citations

Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.

1983 • 374 citations

Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus

1999 • 313 citations

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.

1988 • 281 citations

CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

1994 • 274 citations

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.

1994 • 257 citations

Neurogenic Inflammation

1996 • 196 citations

Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis.

1998 • 180 citations

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P

1999 • 174 citations

Neutral endopeptidase modulation of septic shock.

1995 • 168 citations

Increased substance P responses in dorsal root ganglia and intestinal macrophages duringClostridium difficiletoxin A enteritis in rats

1997 • 165 citations

The control of microvascular permeability and blood pressure by neutral endopeptidase

1997 • 162 citations

Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation

1989 • 146 citations

Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation

2000 • 136 citations

Increased levels of substance P in the myenteric plexus of Trichinella-infected rats

1992 • 135 citations

Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia/reperfusion in rats

1996 • 126 citations

Relation of peroxidase activity in gut mucosa to inflammation

1978 • 118 citations

Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease

1988 • 115 citations

Increased responsiveness of jejunal longitudinal muscle in Trichinella-infected rats

1988 • 114 citations

Inhibition of neutral endopeptidase potentiates neurogenic inflammation in the rat trachea

1989 • 111 citations

A user's guide for avoiding errors in absorbance image cytometry: a review with original experimental observations

1994 • 101 citations

Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas

1997 • 100 citations

β7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection

2000 • 98 citations

Substance P increases neutrophil adhesion to bronchial epithelial cells.

1994 • 86 citations

Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function

1998 • 78 citations

A user's guide for avoiding errors in absorbance image cytometry: a review with original experimental observations

1994 • 77 citations

Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells

1995 • 77 citations

Tissue distribution and innervation pattern of peptide immunoreactivities in the rat pancreas

1992 • 70 citations

Quantification of colonic lamina propria cells by means of a morphometric point-counting method

1988 • 68 citations

Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine

1993 • 63 citations

Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules

1990 • 61 citations

Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode infected rat

2001 • 57 citations

Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells

1994 • 55 citations

Regulation of E-selectin expression in postischemic intestinal microvasculature

2000 • 55 citations

II. Leukocyte-endothelial cell adhesion in the digestive system

1997 • 46 citations

Peptide immunoreactivities in the ganglionated plexuses and nerve fibers innervating the human gallbladder

1995 • 41 citations

Substance P- and vasoactive intestinal polypeptide-immunoreactive innervation in normal and inflamed pouches after restorative proctocolectomy for ulcerative colitis

1996 • 34 citations

Costimulatory signal through CD86 is important in Th2 response in Trichinella spiralis infected mice

2000 • 12 citations