Antiproliferative role of vitamin D and its analogs--a brief overview.

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Vitamin D

1979 • 3,814 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

The Role of the Vitamin D Endocrine System in Health and Disease

1989 • 1,041 citations

1,25-Dihydroxyvitamin D ₃ Receptors in Human Leukocytes

1983 • 1,030 citations

SERUM 25-HYDROXYVITAMIN D AND COLON CANCER: EIGHT-YEAR PROSPECTIVE STUDY

1989 • 665 citations

Vitamin D3 Affects Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells

2000 • 612 citations

Geographic variation in breast cancer mortality in the United States: A hypothesis involving exposure to solar radiation

1990 • 579 citations

1,25-Dihydroxyvitamin D ₃ : a Novel Immunoregulatory Hormone

1984 • 536 citations

Cyclins and cyclin-dependent kinases: a biochemical view

1995 • 533 citations

Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis).

1990 • 514 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

1984 • 461 citations

1,25(OH) ₂ ‐Vitamin D ₃ receptors: gene regulation and genetic circuitry

1988 • 455 citations

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.

1996 • 300 citations

Immunomodulatory actions of 1,25-Dihydroxyvitamin D3

1995 • 244 citations

Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

1996 • 233 citations

Inhibitory Effects of 1α,25-Dihydroxyvitamin D3 on the G1–S Phase-Controlling Machinery

2001 • 227 citations

Antiproliferative Effect of 1α,25-Dihydroxyvitamin D3 in Human Prostate Cancer Cell Line LNCaP Involves Reduction of Cyclin-Dependent Kinase 2 Activity and Persistent G1 Accumulation

1998 • 225 citations

The immunobiology ofvitamin D

1988 • 215 citations

Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

1999 • 213 citations

Mechanisms and Functions of Vitamin D

2009 • 193 citations

Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin

1997 • 189 citations

The connexin43 gene is responsive to oestrogen

1994 • 187 citations

Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma.

2000 • 182 citations

Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population.

2000 • 181 citations

Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis

2001 • 169 citations

Comparative effects of 1,25(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells

1997 • 164 citations

Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D.

2002 • 163 citations

1alpha,25-Dihydroxyvitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cells.

2000 • 159 citations

Sp1 and NF-Y Synergistically Mediate the Effect of Vitamin D3 in the p27Kip1 Gene Promoter That Lacks Vitamin D Response Elements

1999 • 159 citations

Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

1985 • 146 citations

Vitamin D and genomic stability

2001 • 133 citations

Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.

2000 • 130 citations

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3.

1994 • 127 citations

Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum.

2000 • 125 citations

1,25-Dihydroxyvitamin D3 Stimulates Activator Protein-1-dependent Caco-2 Cell Differentiation

1999 • 122 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

Synergistic growth inhibition of prostate cancer cells by 1α,25 Dihydroxyvitamin D3 and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A

2001 • 117 citations

Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line.

1992 • 108 citations

1α,25-Dihydroxyvitamin D3 Inhibits Prostate Cancer Cell Growth by Androgen-Dependent and Androgen-Independent Mechanisms*

2000 • 102 citations

The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro.

1987 • 102 citations

1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells.

1995 • 99 citations

Regulation of epidermal growth factor receptor levels by 1,25-dihydroxyvitamin D3 in human breast cancer cells.

1988 • 99 citations

Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.

1998 • 98 citations

Gap junctional communication and neoplastic transformation.

1993 • 96 citations

Vitamin D Metabolism in Patients Intoxicated with Ergocalciferol

1985 • 93 citations

EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro

1998 • 90 citations

Vitamin D receptor expression is required for growth modulation by 1α,25-dihydroxyvitamin D3 in the human prostatic carcinoma cell line ALVA-31

1996 • 89 citations

Antiproliferative responses to two human colon cancer cell lines to vitamin D3 are differently modified by 9-cis-retinoic acid.

1996 • 87 citations

5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.

1999 • 87 citations

1,25-Dihydroxyvitamin D3 Induces Differentiation of a Retinoic Acid–Resistant Acute Promyelocytic Leukemia Cell Line (UF-1) Associated With Expression of p21WAF1/CIP1 and p27KIP1

1999 • 86 citations

Vitamin D Arrests Thyroid Carcinoma Cell Growth and Induces p27 Dephosphorylation and Accumulation through PTEN/Akt-Dependent and -Independent Pathways

2002 • 84 citations

Hypercalcemia and hyperosteolysis in vitamin D intoxication: Effects of clodronate therapy

1994 • 84 citations

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia

1996 • 81 citations

Sites of lipoprotein particles in normal rat hepatocytes.

1978 • 80 citations

Vitamin D and Vitamin D Analogs in Cancer Treatment

2002 • 76 citations

Negative Regulation of CD95 Ligand Gene Expression by Vitamin D3 in T Lymphocytes

2002 • 73 citations

Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone

1993 • 69 citations

SHORT COMMUNICATION: Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

1996 • 62 citations

Induction of differentiation by 1α-hydroxyvitamin D5 in T47D human breast cancer cells and its interaction with vitamin D receptors

2000 • 59 citations

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents

1995 • 53 citations

Vitamin‐D₃ derivatives and breast‐tumor cell growth: Effect on intracellular calcium and apoptosis

1995 • 47 citations

25-Hydroxyvitamin D levels in patients treated with high-dosage ergo- and cholecalciferol.

1977 • 45 citations

MCF‐7/VD^R: A new vitamin D resistant cell line

2001 • 35 citations

Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3

1996 • 35 citations

Inhibition of DNA synthesis by an inducer of differentiation of leukemic cells, 1 alpha, 25 dihydroxy vitamin D₃, precedes down regulation of the c‐myc gene

1986 • 34 citations

Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1α,25-dihydroxyvitamin D3

2000 • 33 citations

Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: A role for insulin-like growth factor binding proteins.

1999 • 31 citations

The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells

2002 • 30 citations

Changes in c-myc expression and the kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells

1994 • 29 citations

Telomerase activity in acute myelogenous leukaemia: clinical and biological implications

1998 • 27 citations

Combined supplementation of vanadium and 1α,25-dihydroxyvitamin D3 inhibit diethylnitrosamine-induced rat liver carcinogenesis

2000 • 22 citations

Combined supplementation of vanadium and 1α,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis

2000 • 21 citations

Demonstration of vitamin D receptor expression in a human megakaryoblastic leukemia cell line: Regulation of vitamin D receptor mRNA expression and responsiveness by forskolin

1996 • 20 citations

1α, 25-Dihydroxyvitamin D3 inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis

2001 • 19 citations

1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells

1986 • 18 citations

Use of Vitamins A and D in Chemoprevention and Therapy of Cancer: Control of Nuclear Receptor Expression and Function

1995 • 17 citations

Retinoblastoma protein-overexpressing HL60 cells resistant to 1,25-dihydroxyvitamin D3 display increased CDK2 and CDK6 activity and shortened G1 phase

1998 • 17 citations

1?,25-dihydroxyvitamin D3 inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis

2001 • 16 citations

1α, 25‐DIHYDROXYVITAMIN D₃ SUPPRESSES THE EFFECT OF STREPTOZOTOCIN‐INDUCED DIABETES DURING CHEMICAL RAT LIVER CARCINOGENESIS

2001 • 15 citations

A phase one study of the hepatic arterial administration of 1,25‐dihydroxyvitamin D₃ for liver cancers

2001 • 14 citations

1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.

1997 • 13 citations

Long-Term Exposure of HL60 Cells to 1,25-Dihydroxyvitamin D3 Reduces Their Tumorigenicity: A Model for Cancer Chemoprevention

1997 • 12 citations

1,25-Dihydroxyvitamin D3Suppresses the Expression of the VCAM-1 Receptor, VLA-4 in Human Leukemic HL-60 Cells

1999 • 11 citations

Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity.

1998 • 9 citations

Calcitriol-mediated modulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-2

1991 • 8 citations

Role of Vitamin D₃on the Activity Patterns of Hepatic Drug Metabolizing Enzymes in Transplantable Murine Lymphoma

1996 • 5 citations