Alternative Splicing of a Short Cassette Exon in α_1BGenerates Functionally Distinct N-Type Calcium Channels in Central and Peripheral Neurons

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

The NEURON Simulation Environment

1997 • 2,612 citations

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

1996 • 2,308 citations

Reliability of Spike Timing in Neocortical Neurons

1995 • 1,957 citations

Roles of N-Type and Q-Type Ca ²⁺ Channels in Supporting Hippocampal Synaptic Transmission

1994 • 964 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 920 citations

Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 • 859 citations

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons

1995 • 819 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Different types of calcium channels mediate central synaptic transmission

1993 • 743 citations

CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE: The ω-Conotoxins and ω-Agatoxins

1994 • 734 citations

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.

1989 • 631 citations

Structure and Functional Expression of a Member of the Low Voltage-Activated Calcium Channel Family

1993 • 572 citations

Structure and Functional Expression of an ω-Conotoxin-Sensitive Human N-Type Calcium Channel

1992 • 496 citations

Linearized Buffered Ca²⁺Diffusion in Microdomains and Its Implications for Calculation of [Ca²⁺] at the Mouth of a Calcium Channel

1997 • 492 citations

Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits

1993 • 431 citations

Identification of a syntaxin-binding site on N-Type calcium channels

1994 • 429 citations

Calcium requirements for secretion in bovine chromaffin cells.

1992 • 416 citations

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

1996 • 410 citations

Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.

1994 • 366 citations

Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS

1991 • 366 citations

Voltage Sensor–Trapping

1998 • 328 citations

Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications

1995 • 321 citations

Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel.

1992 • 317 citations

Primary structure of a calcium channel that is highly expressed in the rat cerebellum.

1991 • 309 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 293 citations

Calcium Channels Coupled to Glutamate Release Identified by ω-Aga-IVA

1992 • 292 citations

Multiple channels and calcium dynamics

1989 • 250 citations

Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rabbit brain

1993 • 230 citations

Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

1997 • 221 citations

Molecular determinants of voltage-dependent inactivation in calcium channels

1994 • 217 citations

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes

1990 • 217 citations

Alternatively Spliced IS6 Segments of the α _1C Gene Determine the Tissue-Specific Dihydropyridine Sensitivity of Cardiac and Vascular Smooth Muscle L-Type Ca ²⁺ Channels

1997 • 215 citations

Modulation of voltage-dependent calcium channels by G proteins

1998 • 212 citations

Identification of Functionally Distinct Isoforms of the N-Type Ca2+ Channel in Rat Sympathetic Ganglia and Brain

1997 • 193 citations

Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin

1994 • 186 citations

A Xenopus oocyte β subunit: Evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit

1997 • 181 citations

Molecular Structures Involved in L-type Calcium Channel Inactivation

1997 • 144 citations

Genomic Structure of Human L-Type Ca2+ Channel

1994 • 141 citations

Splicing Regulation in Neurons: Tinkering with Cell-Specific Control

1998 • 129 citations

Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels.

1994 • 114 citations

Calcium currents in bullfrog sympathetic neurons. II. Inactivation.

1989 • 114 citations

Class A Calcium Channel Variants in Pancreatic Islets and Their Role in Insulin Secretion

1998 • 89 citations

Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney.

1992 • 77 citations

Ca²⁺ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human α_1C subunit gene

1998 • 76 citations

Structural Elements in Domain IV that Influence Biophysical and Pharmacological Properties of Human α1A-Containing High-Voltage-Activated Calcium Channels

1999 • 74 citations

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells.

1995 • 70 citations

[16] Preparation of RNA for injection into Xenopus oocytes

1992 • 61 citations

Role of the S3-S4 Linker in Shaker Potassium Channel Activation

1997 • 58 citations

Transfer of Voltage Independence from a Rat Olfactory Channel to the Drosophila Ether-à-go-go K+ Channel

1997 • 55 citations

Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone.

1995 • 54 citations

Peripheral versus central potencies of N-type voltage-sensitive calcium channel blockers

1998 • 53 citations

Molecular cloning of a murine N‐type calcium channel α1 subunit

1994 • 47 citations

High-Voltage-Activated Calcium Currents in Neurons Acutely Isolated From the Ventrobasal Nucleus of the Rat Thalamus

1997 • 43 citations

Calcium‐channel gating in frog skeletal muscle membrane: effect of temperature.

1983 • 41 citations

Beta subunit coexpression and the alpha1 subunit domain I-II linker affect piperidine block of neuronal calcium channels

1996 • 41 citations

The Structures of the Human Calcium Channel α1 Subunit (CACNL1A2) and β Subunit (CACNLB3) Genes

1995 • 40 citations

Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit

1997 • 35 citations

The Structure of the Gene Encoding the Human Skeletal Muscle α1Subunit of the Dihydropyridine-Sensitive L-type Calcium Channel (CACNL1A3)

1996 • 30 citations

Molecular diversity and functional characterization of voltage- dependent calcium channels (CACN4) expressed in pancreatic beta-cells

1995 • 29 citations