Pharmacokinetics and Pharmacodynamics of Imatinib in a Phase I Trial With Chronic Myeloid Leukemia Patients

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

The Biology of Chronic Myeloid Leukemia

1999 • 1,308 citations

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study

2002 • 1,195 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

2002 • 923 citations

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

1997 • 646 citations

Role of alpha1 Acid Glycoprotein in the In Vivo Resistance of Human BCR-ABL+ Leukemic Cells to the Abl Inhibitor STI571

2000 • 332 citations

Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis

1997 • 325 citations

Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans

1996 • 308 citations

Role of Body Surface Area in Dosing of Investigational Anticancer Agents in Adults, 1991-2001

2002 • 281 citations

Simultaneous Modeling of Pharmacokinetics and Pharmacodynamics with a Nonparametric Pharmacodynamic Model

1984 • 143 citations

High-throughput quantification of the anti-leukemia drug STI571 (Gleevec™) and its main metabolite (CGP 74588) in human plasma using liquid chromatography–tandem mass spectrometry

2002 • 139 citations

Paclitaxel pharmacokinetics and pharmacodynamics.

1995 • 123 citations

A randomized study of epirubicin at four different dose levels in advanced breast cancer. Feasibility of myelotoxicity prediction through single blood-sample measurement

1991 • 59 citations

Etoposide dosage and pharmacodynamics

1994 • 54 citations

Dose optimisation of carboplatin in adults.

1994 • 38 citations

Dose optimization of carboplatin in adults

1994 • 31 citations