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References (364)

Measuring inconsistency in meta-analyses

2003 • 53,662 citations

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

2016 • 12,036 citations

Construct validity in psychological tests.

1955 • 10,167 citations

The behaviour change wheel: A new method for characterising and designing behaviour change interventions

2011 • 9,229 citations

Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide

2014 • 7,346 citations

The Behavior Change Technique Taxonomy (v1) of 93 Hierarchically Clustered Techniques: Building an International Consensus for the Reporting of Behavior Change Interventions

2013 • 5,993 citations

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

2006 • 5,467 citations

Audit and feedback: effects on professional practice and healthcare outcomes

2012 • 5,301 citations

The Combination of Estimates from Different Experiments

1954 • 4,769 citations

Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship

2006 • 3,189 citations

Segmented regression analysis of interrupted time series studies in medication use research

2002 • 2,824 citations

Effectiveness and efficiency of guideline dissemination and implementation strategies

2004 • 2,813 citations

Effective techniques in healthy eating and physical activity interventions: A meta-regression.

2009 • 2,065 citations

GRADE guidelines: 5. Rating the quality of evidence—publication bias

2011 • 1,561 citations

Designing and evaluating complex interventions to improve health care

2007 • 1,282 citations

Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial

2004 • 1,073 citations

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

2010 • 1,065 citations

Tackling antibiotic resistance

2011 • 993 citations

Short-course Empiric Antibiotic Therapy for Patients with Pulmonary Infiltrates in the Intensive Care Unit

2000 • 993 citations

Effect of Procalcitonin-Based Guidelines vs Standard Guidelines on Antibiotic Use in Lower Respiratory Tract Infections

2009 • 890 citations

Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia

2006 • 850 citations

The stepped wedge trial design: a systematic review

2006 • 847 citations

On the unintended consequences of publishing performance data in the public sector

1995 • 817 citations

Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: Guidelines for the Prevention of Antimicrobial Resistance in Hospitals

1997 • 786 citations

Strategies to Prevent and Control the Emergence and Spread of Antimicrobial-Resistant Microorganisms in Hospitals

1996 • 741 citations

A Controlled Trial of a Critical Pathway for Treatment of Community-Acquired Pneumonia

2000 • 702 citations

Interventions to improve antibiotic prescribing practices in ambulatory care

2005 • 689 citations

Antimicrobial Stewardship Programs in Health Care Systems

2005 • 676 citations

Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis

2016 • 628 citations

Nosocomial Outbreak of Klebsiella Infection Resistant to Late-Generation Cephalosporins

1993 • 605 citations

Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients

2007 • 577 citations

Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia: Estimating the Burden of Antibiotic Resistance in Europe

2011 • 564 citations

Antibiotic Treatment of Exacerbations of COPD

2007 • 512 citations

Accountability Measures — Using Measurement to Promote Quality Improvement

2010 • 497 citations

Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting

2013 • 435 citations

An antibiotic policy to prevent emergence of resistant bacilli

2000 • 419 citations

Favorable Impact of a Multidisciplinary Antibiotic Management Program Conducted During 7 Years

2003 • 403 citations

A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis

2012 • 394 citations

Clinical impact of rapid in vitro susceptibility testing and bacterial identification

1994 • 386 citations

Measurement of Adult Antibacterial Drug Use in 130 US Hospitals: Comparison of Defined Daily Dose and Days of Therapy

2007 • 383 citations

Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*

2011 • 335 citations

Impact of a Reduction in the Use of High-Risk Antibiotics on the Course of an Epidemic of Clostridium difficile-Associated Disease Caused by the Hypervirulent NAP1/027 Strain

2007 • 334 citations

A Randomized Controlled Trial of an Antibiotic Discontinuation Policy for Clinically Suspected Ventilator-Associated Pneumonia

2004 • 311 citations

The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study

2010 • 309 citations

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

2009 • 306 citations

Hospitals collaborate to decrease surgical site infections

2005 • 303 citations

Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial

2009 • 296 citations

The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection

2007 • 286 citations

Meta-Analysis

2009 • 279 citations

Academic Detailing to Improve Use of Broad-Spectrum Antibiotics at an Academic Medical Center

2001 • 274 citations

Categorizing the unintended sociotechnical consequences of computerized provider order entry

2006 • 263 citations

Effect of antibiotic stewardship programmes on Clostridium difficile incidence: a systematic review and meta-analysis

2014 • 253 citations

Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital

1991 • 253 citations

Hospital-wide Restriction of Clindamycin: Effect on the Incidence of Clostridium difficile-Associated Diarrhea and Cost

1998 • 251 citations

Decrease in Nosocomial Clostridium difficile–Associated Diarrhea by Restricting Clindamycin Use

1994 • 239 citations

Clinical Impact of Antimicrobial Resistance in European Hospitals: Excess Mortality and Length of Hospital Stay Related to Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

2011 • 238 citations

Burden of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay associated with bloodstream infections due to Escherichia coli resistant to third-generation cephalosporins

2010 • 237 citations

Behavior Change Strategies to Influence Antimicrobial Prescribing in Acute Care: A Systematic Review

2011 • 233 citations

Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling

2003 • 232 citations

Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study

2008 • 223 citations

Outcomes of an intervention to improve hospital antibiotic prescribing: interrupted time series with segmented regression analysis

2003 • 223 citations

Misdiagnosis of Community-Acquired Pneumonia and Inappropriate Utilization of Antibiotics

2007 • 221 citations

Using theory to synthesise evidence from behaviour change interventions: The example of audit and feedback

2010 • 217 citations

Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use

2007 • 215 citations

interventions to improve antibiotic prescribing practices for hospital inpatients (updated protocol)

2017 • 215 citations

Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia

2001 • 215 citations

Antimicrobial Stewardship at a Large Tertiary Care Academic Medical Center: Cost Analysis Before, During, and After a 7-Year Program

2012 • 210 citations

Reducing Vancomycin Use Utilizing a Computer Guideline: Results of a Randomized Controlled Trial

1998 • 209 citations

Impact of Rapid Detection of Viral and Atypical Bacterial Pathogens by Real-Time Polymerase Chain Reaction for Patients with Lower Respiratory Tract Infection

2005 • 208 citations

Non‐randomized studies as a source of complementary, sequential or replacement evidence for randomized controlled trials in systematic reviews on the effects of interventions

2013 • 207 citations

Unintended Effects of a Computerized Physician Order Entry Nearly Hard-Stop Alert to Prevent a Drug Interaction

2010 • 206 citations

Antibiotic optimization. An evaluation of patient safety and economic outcomes

1997 • 201 citations

Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial

2006 • 199 citations

Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection

2011 • 198 citations

Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy

1997 • 198 citations

Effect of Increasing the Intensity of Implementing Pneumonia Guidelines

2005 • 197 citations

Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes

2011 • 197 citations

Clinical impact of rapid identification and susceptibility testing of bacterial blood culture isolates

1989 • 196 citations

Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series

2007 • 193 citations

Audit and Feedback to Reduce Broad-Spectrum Antibiotic Use among Intensive Care Unit Patients A Controlled Interrupted Time Series Analysis

2012 • 192 citations

Improving Empiric Antibiotic Selection Using Computer Decision Support

1994 • 182 citations

Public Reporting of Antibiotic Timing in Patients with Pneumonia: Lessons from a Flawed Performance Measure

2008 • 181 citations

Procalcitonin Algorithm in Critically Ill Adults with Undifferentiated Infection or Suspected Sepsis. A Randomized Controlled Trial

2014 • 179 citations

Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis

2013 • 179 citations

Antibiotic Timing and Errors in Diagnosing Pneumonia

2008 • 178 citations

Building Measurement and Data Collection into Medical Practice

1998 • 177 citations

Reduction in the Incidence of Methicillin‐Resistant Staphylococcus aureus and Ceftazidime‐Resistant Klebsiella pneumoniae Following Changes in a Hospital Antibiotic Formulary

1999 • 171 citations

Impact of a Computerized Clinical Decision Support System on Reducing Inappropriate Antimicrobial Use: A Randomized Controlled Trial

2006 • 170 citations

Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile

2008 • 165 citations

Fluoroquinolone Use and Methicillin-Resistant Staphylococcus aureus Isolation Rates in Hospitalized Patients: A Quasi Experimental Study

2006 • 163 citations

Usage of Antibiotics in a General Hospital: Effect of Requiring Justification

1974 • 162 citations

Safer Prescribing — A Trial of Education, Informatics, and Financial Incentives

2016 • 160 citations

Measurement of Interleukin 8 in Combination With C-Reactive Protein Reduced Unnecessary Antibiotic Therapy in Newborn Infants: A Multicenter, Randomized, Controlled Trial

2004 • 159 citations

Room for improvement: a systematic review of the quality of evaluations of interventions to improve hospital antibiotic prescribing

2003 • 157 citations

An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings

2012 • 155 citations

Bronchiolitis Management Before and After the AAP Guidelines

2013 • 152 citations

The control of hyperendemic glycopeptide-resistant Enterococcus spp. on a haematology unit by changing antibiotic usage

1999 • 151 citations

Use of Procalcitonin-Guided Decision-Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis: Prospective Randomized Intervention Trial

2009 • 150 citations

Improved Clinical Outcomes With Utilization of a Community-Acquired Pneumonia Guideline

2006 • 148 citations

The impact of removing financial incentives from clinical quality indicators: longitudinal analysis of four Kaiser Permanente indicators

2010 • 147 citations

Identification of targets for quality improvement in antimicrobial prescribing: the web-based ESAC Point Prevalence Survey 2009

2010 • 147 citations

Procalcitonin measurements for guiding antibiotic treatment in pediatric pneumonia

2011 • 146 citations

Improvement of Process‐of‐Care and Outcomes after Implementing a Guideline for the Management of Community‐Acquired Pneumonia: A Controlled Before‐and‐After Design Study

2004 • 143 citations

Antibiotic Optimization

1997 • 143 citations

Electronic antibiotic stewardship--reduced consumption of broad-spectrum antibiotics using a computerized antimicrobial approval system in a hospital setting

2008 • 143 citations

Stroke Unit Versus General Medical Wards, II: Neurological Deficits and Activities of Daily Living

1998 • 138 citations

Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus

2012 • 138 citations

Antibiotic cost savings from formulary restrictions and physician monitoring in a medical-school-affiliated hospital

1987 • 135 citations

Quality improvement of surgical prophylaxis in Dutch hospitals: evaluation of a multi-site intervention by time series analysis

2005 • 135 citations

Impact of an Antimicrobial Utilization Program on Antimicrobial Use at a Large Teaching Hospital A Randomized Controlled Trial

2009 • 131 citations

Effect of a 3-Step Critical Pathway to Reduce Duration of Intravenous Antibiotic Therapy and Length of Stay in Community-Acquired Pneumonia

2012 • 129 citations

Antibiotic treatment interruption of suspected lower respiratory tract infections based on a single procalcitonin measurement at hospital admission—a randomized trial

2009 • 127 citations

Bloodstream Infections: A Trial of the Impact of Different Methods of Reporting Positive Blood Culture Results

2004 • 125 citations

A Randomized, Prospective Study Measuring Outcomes after Antibiotic Therapy Intervention by a Multidisciplinary Consult Team

1999 • 125 citations

Reduction in colonization and nosocomial infection by multiresistant bacteria in a neonatal unit after institution of educational measures and restriction in the use of cephalosporins

2001 • 124 citations

Effective Antimicrobial Stewardship in a Long-Term Care Facility through an Infectious Disease Consultation Service: Keeping a LID on Antibiotic Use

2012 • 124 citations

Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients*

2012 • 123 citations

Reduction in broad-spectrum antimicrobial use associated with no improvement in hospital antibiogram

2004 • 121 citations

Reduction of Incorrect Antibiotic Dosing Through a Structured Educational Order Form

1988 • 119 citations

Clinical Impact of RT-PCR for Pediatric Acute Respiratory Infections: A Controlled Clinical Trial

2011 • 115 citations

Impact of a Prospective-Audit-With-Feedback Antimicrobial Stewardship Program at a Children's Hospital

2012 • 115 citations

Practices to Improve Antimicrobial Use at 47 US Hospitals the Status of the 1997 SHEA/IDSA Position Paper Recommendations

2000 • 114 citations

Changes in the Prevalence of Vancomycin‐Resistant Enterococci in Response to Antimicrobial Formulary Interventions: Impact of Progressive Restrictions on Use of Vancomycin and Third‐Generation Cephalosporins

2003 • 114 citations

Accuracy and Impact of a Point-of-Care Rapid Influenza Test in Young Children With Respiratory Illnesses

2006 • 114 citations

Randomised trial of educational visits to enhance use of systematic reviews in 25 obstetric units

1998 • 113 citations

The Effect of an Interactive Visual Reminder in an Anesthesia Information Management System on Timeliness of Prophylactic Antibiotic Administration

2007 • 112 citations

European Surveillance of Antibiotic Consumption (ESAC) point prevalence survey 2008: paediatric antimicrobial prescribing in 32 hospitals of 21 European countries

2010 • 110 citations

Improved susceptibility of Gram-negative bacteria in an intensive care unit following implementation of a computerized antibiotic decision support system

2010 • 110 citations

Risk of AKI with Gentamicin as Surgical Prophylaxis

2014 • 109 citations

Palliative Care in Advanced Dementia: A Randomized Controlled Trial and Descriptive Analysis

2000 • 109 citations

Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy

2005 • 107 citations

A controlled trial of the cost benefit of computerized bayesian aminoglycoside administration

1991 • 105 citations

Evaluation of a pneumonia practice guideline in an interventional trial.

1996 • 105 citations

Impact of changes in antibiotic policy on Clostridium difficile-associated diarrhoea (CDAD) over a five-year period in a district general hospital

2003 • 105 citations

Impact of a Guideline on Management of Children Hospitalized With Community-Acquired Pneumonia

2012 • 105 citations

Quality Health Care: A Guide to Developing and Using Indicators

2017 • 105 citations

Antimicrobial Stewardship—the State of the Art in 2011 Focus on Outcome and Methods

2012 • 104 citations

Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units*

2006 • 104 citations

Aminoglycoside resistance in gram-negative bacilli during increased amikacin use

1985 • 103 citations

Antibiotic Rotation and Development of Gram-Negative Antibiotic Resistance

2004 • 103 citations

Monitoring Antimicrobial Use and Resistance: Comparison with a National Benchmark on Reducing Vancomycin Use and Vancomycin-Resistant Enterococci

2002 • 99 citations

Implementation of an evidence-based guideline to reduce duration of intravenous antibiotic therapy and length of stay for patients hospitalized with community-acquired pneumonia: a randomized controlled trial

2003 • 98 citations

Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides

1990 • 96 citations

Inpatient Bronchiolitis Guideline Implementation and Resource Utilization

2014 • 96 citations

Direct E-Test (AB Biodisk) of Respiratory Samples Improves Antimicrobial Use in Ventilator-Associated Pneumonia

2007 • 95 citations

Antibiotic Use, Hospital Admissions, and Mortality Before and After Implementing Guidelines for Nursing Home–Acquired Pneumonia

2001 • 93 citations

Impact of a Bronchiolitis Guideline on ED Resource Use and Cost: A Segmented Time-Series Analysis

2013 • 88 citations

Reduction of broad-spectrum antibiotic use with computerized decision support in an intensive care unit

2006 • 88 citations

Concurrent Quality Assurance in Hospital Care

1978 • 88 citations

Complete Restriction of Fluoroquinolone Use to Control an Outbreak ofClostridium difficileInfection at a Community Hospital

2009 • 87 citations

Pharmacy-implemented guidelines on switching from intravenous to oral antibiotics: an intervention study

2005 • 87 citations

Procalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial

2013 • 86 citations

Early Discharge of Infected Patients Through Appropriate Antibiotic Use

2001 • 86 citations

Reducing Infections Among Women Undergoing Cesarean Section in Colombia by Means of Continuous Quality Improvement Methods

2001 • 85 citations

Improving compliance with hospital antibiotic guidelines: a time-series intervention analysis

2005 • 84 citations

Evaluation of an Intervention Designed to Decrease the Rate of Nosocomial Methicillin-ResistantStaphylococcus aureusInfection by Encouraging Decreased Fluoroquinolone Use

2006 • 84 citations

Control of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a children's hospital by changing antimicrobial agent usage policy

2007 • 83 citations

Impact of the pharmacist on a multidisciplinary team in an antimicrobial stewardship program: a quasi-experimental study

2012 • 83 citations

Antibiotic Self-stewardship: Trainee-Led Structured Antibiotic Time-outs to Improve Antimicrobial Use

2014 • 83 citations

The Effect of Antibiotic Rotation on Colonization With Antibiotic-Resistant Bacilli in a Neonatal Intensive Care Unit

2002 • 83 citations

Close cooperation between infectious disease physicians and attending physicians can result in better management and outcome for patients with Staphylococcus aureus bacteraemia

2010 • 82 citations

Improved Antimicrobial Interventions Have Benefits

2001 • 79 citations

Reduced Use of Third-Generation Cephalosporins Decreases the Acquisition of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae

2004 • 78 citations

Antibiotic stewardship implementation in the EU: the way forward

2009 • 76 citations

Intervention to Discontinue Parenteral Antimicrobial Therapy in Patients Hospitalized with Pulmonary Infections: Effect on Shortening Patient Stay

1992 • 75 citations

Prospective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore

2011 • 75 citations

Changing antibiotic prescribing by educational marketing

1988 • 75 citations

Improving antibiotic prescribing for adults with community acquired pneumonia: Does a computerised decision support system achieve more than academic detailing alone? – a time series analysis

2008 • 75 citations

Antibiotic restriction does not alter endemic colonization with resistant Gram-negative rods in a pediatric intensive care unit

1998 • 75 citations

Mortality associated with in-hospital bacteraemia caused by Staphylococcus aureus: a multistate analysis with follow-up beyond hospital discharge

2010 • 73 citations

An antibiotic policy associated with reduced risk of Clostridium difficile-associated diarrhoea

1999 • 73 citations

Cluster randomised trial of an active, multifaceted educational intervention based on the WHO Reproductive Health Library to improve obstetric practices

2006 • 72 citations

Reduction of fluoroquinolone use is associated with a decrease in methicillin-resistant Staphylococcus aureus and fluoroquinolone-resistant Pseudomonas aeruginosa isolation rates: a 10 year study

2012 • 72 citations

A Multidisciplinary Intervention to Reduce Infections of ESBL- and AmpC-Producing, Gram-Negative Bacteria at a University Hospital

2014 • 72 citations

Tailored Interventions to Improve Antibiotic Use for Lower Respiratory Tract Infections in Hospitals: A Cluster-Randomized, Controlled Trial

2007 • 71 citations

Reducing door-to-antibiotic time in community-acquired pneumonia: controlled before-and-after evaluation and cost-effectiveness analysis

2006 • 70 citations

A Pharmacist‐Initiated Program of Intravenous to Oral Antibiotic Conversion

1997 • 69 citations

An Educational Intervention to Improve Antimicrobial Use in a Hospital‐Based Long‐Term Care Facility

2007 • 68 citations

Impact of a multidisciplinary approach to the control of antibiotic prescription in a general hospital

2003 • 68 citations

Pharmacist interventions on antibiotic use in inpatients with respiratory tract infections in a Chinese hospital

2011 • 66 citations

A randomized, prospective evaluation of an interventional program to discontinue intravenous antibiotics at two tertiary care teaching institutions.

1997 • 66 citations

Improvement of Intraoperative Antibiotic Prophylaxis in Prolonged Cardiac Surgery by Automated Alerts in the Operating Room

2003 • 65 citations

Effectiveness of a procalcitonin algorithm to guide antibiotic therapy in respiratory tract infections outside of study conditions: a post-study survey

2009 • 65 citations

Results of an antimicrobial control program at a university hospital

2005 • 65 citations

Clinical impact of unsolicited post-prescription antibiotic review in surgical and medical wards: a randomized controlled trial

2012 • 65 citations

The Sepsis Six: helping patients to survive sepsis

2008 • 65 citations

Changing Surgical Antimicrobial Prophylaxis Practices Through Education Targeted at Senior Department Leaders

1990 • 65 citations

REDUCTION OF VANCOMYCIN-RESISTANT ENTEROCOCCAL INFECTIONS BY LIMITATION OF BROAD-SPECTRUM CEPHALOSPORIN USE IN A TRAUMA AND BURN INTENSIVE CARE UNIT

2000 • 62 citations

Improving the Quality of Care for Patients With Pneumonia in Very Small Hospitals

2003 • 62 citations

Antimicrobial stewardship program directed at broad-spectrum intravenous antibiotics prescription in a tertiary hospital

2009 • 62 citations

Trends inStaphylococcus aureusbacteraemia and impacts of infection control practices including universal MRSA admission screening in a hospital in Scotland, 2006–2010: retrospective cohort study and time-series intervention analysis

2012 • 61 citations

Antibiotic Resistance Patterns During Aminoglycoside Restriction

1985 • 60 citations

Adherence to an antibiotic stewardship bundle targeting Staphylococcus aureus blood stream infections at a 200-bed community hospital

2014 • 59 citations

Effectiveness of feedback for improving case management of malaria, diarrhoea and pneumonia – a randomized controlled trial at provincial hospitals in Lao PDR

2003 • 59 citations

Decreasing Clostridium difficile Infections by an Antimicrobial Stewardship Program That Reduces Moxifloxacin Use

2014 • 59 citations

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry and PCR-based rapid diagnosis of Staphylococcus aureus bacteraemia

2013 • 59 citations

Sustained reduction in antimicrobial use and decrease in methicillin-resistant Staphylococcus aureus and Clostridium difficile infections following implementation of an electronic medical record at a tertiary-care teaching hospital

2010 • 58 citations

The emergency department community-acquired pneumonia trial: Methodology of a quality improvement intervention.

2004 • 58 citations

Impact of an intervention to control Clostridium difficile infection on hospital- and community-onset disease; an interrupted time series analysis

2009 • 58 citations

Improving Timeliness of Antibiotic Delivery for Patients With Fever and Suspected Neutropenia in a Pediatric Emergency Department

2012 • 58 citations

Prospective Audit and Feedback of Antimicrobial Stewardship in Critical Care: Program Implementation, Experience, and Challenges

2012 • 58 citations

Does social marketing provide a framework for changing healthcare practice?

2009 • 57 citations

Design of a 'day 3 bundle' to improve the reassessment of inpatient empirical antibiotic prescriptions

2008 • 56 citations

The Effect of a Quality Improvement Collaborative to Improve Antimicrobial Prophylaxis in Surgical Patients

2008 • 56 citations

Optimizing the timing of antimicrobial prophylaxis in surgery: an intervention study

1996 • 56 citations

Impact of a web‐based antimicrobial approval system on broad‐spectrum cephalosporin use at a teaching hospital

2003 • 55 citations

Positive Impact of a Therapeutic Drug-Monitoring Program on Total Aminoglycoside Dose and Cost of Hospitalization

1987 • 55 citations

A Randomized, Prospective Evaluation of an Interventional Program to Discontinue Intravenous Antibiotics at Two Tertiary Care Teaching Institutions

1997 • 54 citations

Evaluation of Antimicrobial Therapy Orders Circumventing an Antimicrobial Stewardship Program: Investigating the Strategy of “Stealth Dosing”

2007 • 54 citations

Modified guidelines impact on antibiotic use and costs: duration of treatment for pneumonia in a neurosurgical ICU is reduced

2007 • 53 citations

A Clinical Trial Comparing Physician Prompting With an Unprompted Automated Electronic Checklist to Reduce Empirical Antibiotic Utilization

2013 • 53 citations

Improving appropriateness of antibiotic therapy: randomized trial of an intervention to foster reassessment of prescription after 3 days

2004 • 53 citations

Procalcitonin-Guided Antibiotic Use in Acute Exacerbations of Idiopathic Pulmonary Fibrosis

2013 • 53 citations

Hospital-wide modification of fluoroquinolone policy and meticillin-resistant Staphylococcus aureus rates: a 10-year interrupted time-series analysis

2011 • 52 citations

Implementation and outcomes of a hospital-wide computerised antimicrobial stewardship programme in a large medical centre in Taiwan

2011 • 52 citations

Introduction of Ertapenem into a Hospital Formulary: Effect on Antimicrobial Usage and Improved In Vitro Susceptibility of Pseudomonas aeruginosa

2009 • 52 citations

Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit

2009 • 52 citations

Increase and change in pattern of hospital antimicrobial use, Denmark, 1997–2001

2004 • 51 citations

Assessing the reliability of standardized performance indicators

2006 • 51 citations

Overview of strategies for overcoming the challenge of antimicrobial resistance

2010 • 50 citations

Implementation of an intensified antibiotic stewardship programme targeting third-generation cephalosporin and fluoroquinolone use in an emergency medicine department

2014 • 50 citations

Economic assessment of the community-acquired pneumonia intervention trial employing levofloxacin

2000 • 49 citations

Economic Consequences of Two Drug-use Control Systems in a Teaching Hospital

1988 • 49 citations

Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center

2014 • 49 citations

Results of a Local Antibiotic Management Program on Antibiotic Use in a Tertiary Intensive Care Unit in Hungary

2008 • 49 citations

Use of antimicrobial drugs in adults before and after removal of a restriction policy

1991 • 48 citations

Limited Impact of a Multicenter Intervention To Improve the Quality and Efficiency of Pneumonia Care

2004 • 47 citations

Impact of Infectious Diseases Society of America/Pediatric Infectious Diseases Society Guidelines on Treatment of Community-Acquired Pneumonia in Hospitalized Children

2014 • 47 citations

Hospital-wide Rollout of Antimicrobial Stewardship: A Stepped-Wedge Randomized Trial

2014 • 47 citations

Immediate Incubation of Blood Cultures Outside Routine Laboratory Hours of Operation Accelerates Antibiotic Switching

2009 • 46 citations

Point-of-Care Electronic Prompts

2011 • 46 citations

A Statewide Collaborative to Reduce Pediatric Surgical Site Infections

2014 • 46 citations

Effectiveness of drug use evaluation and antibiotic authorization on patients' clinical outcomes, antibiotic consumption, and antibiotic expenditures

2009 • 45 citations

The nonvalue of retrospective peer comparison Feedback in containing hospital antibiotic costs

1989 • 45 citations

Control of extended-spectrum -lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use

2008 • 44 citations

Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum beta-lactamase-producing organisms.

2003 • 44 citations

Intervention to Discontinue Parenteral Antimicrobial Therapy in Patients Hospitalized with Pulmonary Infections: Effect on Shortening Patient Stay

1992 • 43 citations

Effect of reduction in ciprofloxacin use on prevalence of meticillin-resistant Staphylococcus aureus rates within individual units of a tertiary care hospital

2006 • 43 citations

Consequences for Innovation

2006 • 42 citations

Model for Improvement - Part Two: Measurement and Feedback for Quality Improvement Efforts

2009 • 42 citations

Procalcitonin is a good tool to guide duration of antibiotic therapy in patients with severe acute pancreatitis. A randomized prospective single-center controlled trial.

2012 • 42 citations

The Impact of Policy Guidelines on Hospital Antibiotic Use over a Decade: A Segmented Time Series Analysis

2014 • 42 citations

Implementing an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a 200-bed community hospital in Germany

2014 • 41 citations

Effect of Clinical Pharmacy Services on Prescribing on an Orthopedic Unit

1983 • 40 citations

Control of Nosocomial Multiresistant Enterobacteriaceae Using a Temporary Restrictive Antibiotic Agent Policy

2001 • 40 citations

Effect of Optimized Antibiotic Prophylaxis on the Incidence of Surgical Site Infection

2006 • 40 citations

Antibiotic handbook and pre-printed perioperative order forms for surgical antibiotic prophylaxis: do they work?

1990 • 39 citations

Effect of Communication Errors During Calls to an Antimicrobial Stewardship Program

2007 • 38 citations

Impact of electronic prescribing in a hospital setting: A process-focused evaluation

2007 • 38 citations

Lack of effect of shorter turnaround time of microbiological procedures on clinical outcomes: a randomised controlled trial among hospitalised patients in the Netherlands

2005 • 38 citations

A randomised controlled trial of a tailored multifaceted strategy to promote implementation of a clinical guideline on induced abortion care

2004 • 38 citations

Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: Insights into the ProHOSP study

2010 • 37 citations

Radical reduction of cephalosporin use at a tertiary hospital after educational antibiotic intervention during an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae

2011 • 37 citations

Impact of the Lab-Score on Antibiotic Prescription Rate in Children with Fever without Source: A Randomized Controlled Trial

2014 • 37 citations

Effects of Group 1 versus Group 2 Carbapenems on the Susceptibility of Acinetobacter baumannii to Carbapenems: A Before and After Intervention Study of Carbapenem-Use Stewardship

2014 • 37 citations

The effect of Surgical Care Improvement Project measures on national trends on surgical site infections in open vascular procedures

2014 • 37 citations

The effect of rapid diagnostic testing for influenza on the reduction of antibiotic use in paediatric emergency department

2009 • 37 citations

Improving Door-to-Antibiotic Time in Severely Septic Emergency Department Patients

2011 • 37 citations

Oral quinolones in hospitalized patients: an evaluation of a computerized decision support intervention*

2004 • 37 citations

Contribution of antimicrobial stewardship programs to reduction of antimicrobial therapy costs in community hospital with 429 Beds --before-after comparative two-year trial in Japan

2014 • 36 citations

Fighting the spread of AmpC-hyperproducing Enterobacteriaceae: beneficial effect of replacing ceftriaxone with cefotaxime

2013 • 36 citations

Use of clinical pharmacists to reduce cefamandole, cefoxitin, and ticarcillin costs.

1982 • 36 citations

Evaluation of dedicated infectious diseases pharmacists on antimicrobial stewardship teams

2014 • 36 citations

Multifaceted intervention to optimize antibiotic use for intra-abdominal infections

2014 • 35 citations

Differences in the changes in resistance patterns to third- and fourth-generation cephalosporins and piperacillin/tazobactam among Klebsiella pneumoniae and Escherichia coli clinical isolates following a restriction policy in a Greek tertiary care hospital

2006 • 34 citations

An interrupted time series analysis of parenteral antibiotic use in Colombia

2003 • 34 citations

Impact of restriction of third generation cephalosporins on the burden of third generation cephalosporin resistant K. pneumoniae and E. coli in an ICU

2008 • 34 citations

Modification in prescribing practices for third-generation cephalosporins and ciprofloxacin is associated with a reduction in meticillin-resistant Staphylococcus aureus bacteraemia rate

2008 • 34 citations

Impact of an interdisciplinary strategy on antibiotic use: a prospective controlled study in three hospitals

2005 • 33 citations

Impact of a Change in Antibiotic Prophylaxis on Total Antibiotic Use in a Surgical Intensive Care Unit

2009 • 33 citations

Procalcitonin-based therapeutic strategy to reduce antibiotic use in patients after cardiac surgery: A randomized controlled trial

2011 • 32 citations

Changing Surgical Antimicrobial Prophylaxis Practices through Education Targeted at Senior Department Leaders

1990 • 32 citations

Adherence to recommendations by infectious disease consultants and its influence on outcomes of intravenous antibiotic-treated hospitalized patients

2012 • 32 citations

Procalcitonin guidance for reduction of antibiotic use in patients hospitalized with severe acute exacerbations of asthma: a randomized controlled study with 12-month follow-up

2014 • 32 citations

Reduction in the use of diagnostic tests in infants with risk factors for early-onset neonatal sepsis does not delay antibiotic treatment

2014 • 32 citations

Nursing Home‐Acquired Pneumonia: Outcomes from a Clinical Process Improvement Program

1995 • 32 citations

Limiting vancomycin use to combat vancomycin-resistant Enterococcus faecium

1996 • 32 citations

A RANDOMIZED TRIAL TO MEASURE THE OPTIMAL ROLE OF THE PHARMACIST IN PROMOTING EVIDENCE-BASED ANTIBIOTIC USE IN ACUTE CARE HOSPITALS

2001 • 31 citations

Empiric antibiotic, mechanical ventilation, and central venous catheter duration as potential factors mediating the effect of a checklist prompting intervention on mortality: an exploratory analysis

2012 • 31 citations

Implementation of guidelines for sequential therapy with fluoroquinolones in a Belgian hospital

2010 • 31 citations

Impact of an antibiotic policy on antibiotic use in a paediatric department. Individual based follow-up shows that antibiotics were chosen according to diagnoses and bacterial findings

2002 • 30 citations

Improving Quinolone Use in Hospitals by Using a Bundle of Interventions in an Interrupted Time Series Analysis

2010 • 30 citations

Effectiveness of a Vancomycin Restriction Policy in Changing the Prescribing Patterns of House Staff

2000 • 30 citations

Effects of Monitoring the Usage of Antibiotics

1976 • 29 citations

Reduction in Fluoroquinolone Use following Introduction of Ertapenem into a Hospital Formulary Is Associated with Improvement in Susceptibility of Pseudomonas aeruginosa to Group 2 Carbapenems: a 10-Year Study

2011 • 29 citations

Long-term survival in patients included in a randomized controlled trial of TREAT, a decision support system for antibiotic treatment

2013 • 28 citations

A team approach to hospital formulary replacement

1995 • 28 citations

Optimizing use of ciprofloxacin: a prospective intervention study

2007 • 28 citations

Audit and feedback of antibiotic use

2013 • 28 citations

Hand Hygiene, and Not Ertapenem Use, Contributed to Reduction of Carbapenem-Resistant Pseudomonas aeruginosa Rates

2011 • 27 citations

A pseudo-outbreak of nosocomial infections associated with the introduction of an antibiotic management programme

2003 • 27 citations

Department of pharmacy-initiated program for streamlining empirical antibiotic therapy.

1992 • 27 citations

Decreasing Time to Antibiotics in Febrile Patients With Central Lines in the Emergency Department

2014 • 27 citations

A Pilot Study of Antibiotic Cycling in the Community Hospital Setting

2005 • 27 citations

Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings

2013 • 27 citations

Optimizing antibiotic usage in adults admitted with fever by a multifaceted intervention in an Indonesian governmental hospital

2008 • 26 citations

Integration of clinical and administrative strategies to reduce expenditures for antimicrobial agents

1990 • 26 citations

Impact of regular attendance by infectious disease specialists on the management of hospitalised adults with community-acquired febrile syndromes

2004 • 26 citations

Performance of the TREAT decision support system in an environment with a low prevalence of resistant pathogens

2008 • 25 citations

A Multidisciplinary Hospital-based Antimicrobial Use Program: Impact on Hospital Pharmacy Expenditures and Drug Use

1995 • 25 citations

Blood culture-guided de-escalation of empirical antimicrobial regimen for critical patients in an online antimicrobial stewardship programme

2014 • 24 citations

Development and evaluation of an implementation strategy for the German guideline on community-acquired pneumonia

2010 • 24 citations

Use of clinical pharmacists to reduce cefamandole, cefoxitin, and ticarcillin costs

1982 • 24 citations

Impact of Automatic Orders to Discontinue Vancomycin Therapy on Vancomycin Use in an Antimicrobial Stewardship Program

2007 • 24 citations

Effectiveness of Pharmacy Policies Designed to Limit Inappropriate Vancomycin Use: A Population-Based Assessment

2002 • 24 citations

Impact of Ceftriaxone De-restriction on the Occurrence of ESBL-Positive Bacterial Strains and Antibiotic Consumption

2011 • 23 citations

Clinical and bacteriological survey after change in aminoglycoside treatment to control an epidemic of Enterobacter cloacae

1994 • 22 citations

Limited efficacy of a nonrestricted intervention on antimicrobial prescription of commonly used antibiotics in the hospital setting: results of a randomized controlled trial

2008 • 21 citations

Effect of antibiotic order form guiding rational use of expensive drugs on cost containment.

1998 • 21 citations

[Clinical significance of dynamic monitoring of procalcitonin in guiding the use of antibiotics in patients with sepsis in ICU].

2013 • 20 citations

Assessing the antimicrobial prescription request process in a teaching hospital in Brazil: regulations and training.

2000 • 20 citations

Reporting hospitals' antibiotic timing in pneumonia: adverse consequences for patients?

2009 • 20 citations

A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series

2013 • 19 citations

Impact of antimicrobial stewardship programme changes on unnecessary double anaerobic coverage therapy

2011 • 19 citations

Implementation of a hospital-wide project for appropriate antimicrobial prophylaxis

2010 • 19 citations

Curtailing unnecessary vancomycin usage in a hospital with high rates of methicillin resistant Staphylococcus aureus infections

2001 • 19 citations

Implementation of a Practical Antibiotic Policy in the Czech Republic

1999 • 19 citations

The Impact of the Docent Clinical Pharmacist on Treatment of Streptococcal Pneumonia

1982 • 19 citations

Intervention to Discontinue Parenteral Antimicrobial Therapy in Hospitalized Patients with Urinary Tract Infection, Skin and Soft Tissue Infection, or No Evident Infection

1993 • 18 citations

Impact of Clinical Pharmacy Services on Prescribing on a Cardiothoracic/Vascular Surgical Unit

1985 • 18 citations

Implications and Impact of Prior Authorization Policy on Vancomycin Use at a Tertiary Pediatric Teaching Hospital

2014 • 18 citations

Impact of an intervention designed to improve the documentation of the reassessment of antibiotic therapies in an intensive care unit

2011 • 17 citations

Audit of antibiotic usage in a medium-sized general hospital over an 11-year period

1995 • 17 citations

Quality Improvements of Antimicrobial Prophylaxis in Coronary Artery Bypass Grafting

2009 • 17 citations

Prospective audit of costs and outcome of aminoglycoside treatment and of therapy for Gram-negative bacteraemia

1995 • 17 citations

Quality of care in sepsis management: development and testing of measures for improvement

2007 • 17 citations

Weekly E‐mail Reminders Influence Emergency Physician Behavior: A Case Study Using the Joint Commission and Centers for Medicare and Medicaid Services Pneumonia Guidelines

2009 • 16 citations

Metronidazole cost containment: a two-stage intervention.

1990 • 16 citations

Specialty Care Delivery: Bringing Infectious Disease Expertise to the Residents of a Veterans Affairs Long‐Term Care Facility

2013 • 16 citations

Effect of a selective restriction policy on antibiotic expenditure and use: an institutional model.

1991 • 16 citations

Measuring the saving attributable to an antibiotic prescribing policy

1988 • 16 citations

Incorporating pharmacy student activities into an antimicrobial stewardship program in a long-term acute care hospital

2014 • 16 citations

Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study

2016 • 15 citations

Use of a preprinted sticker to improve the prescribing of prophylactic antibiotics for hip fracture surgery

2004 • 15 citations

Influencing drug use through prescribing restrictions

1982 • 15 citations

The case for comprehensive quality indicator reliability assessment

2001 • 14 citations

Active promotion of antibiotic guidelines: an intensive program.

2003 • 14 citations

Lessons Learned from ImplementingClostridium difficile–Focused Antibiotic Stewardship Interventions

2014 • 14 citations

The role of general quality improvement measures in decreasing the burden of endemic MRSA in a medical–surgical intensive care unit

2010 • 13 citations

Evaluation of a tool to benchmark hospital antibiotic prescribing in the United Kingdom

2007 • 12 citations

Impacto da implantação de um guia terapêutico para o tratamento de pneumonia nosocomial adquirida na unidade de terapia intensiva em hospital universitário

2007 • 12 citations

Modifying empiric antibiotic prescribing: experience with one strategy in a medical residency program.

1985 • 12 citations

Impact of a restrictive antimicrobial policy on the process and timing of antimicrobial administration

2010 • 12 citations

Improving Prophylactic Perioperative Antibiotic Utilization in a Hospital System

2008 • 12 citations

Impact of Limited Cephalosporin Use on Prevalence of Methicillin-ResistantStaphylococcus aureusin the Intensive Care Unit

2009 • 11 citations

The Effect of an Antibiotic Policy on Bacterial Resistance in Patients in Geriatric Medical Wards

1986 • 11 citations

The Antibiotic Support Team—A Successful Educational Approach to Antibiotic Stewardship

2009 • 11 citations

Impact of Targeted Antibiotic Restriction on Usage and Cost in a Community Hospital

1999 • 10 citations

Does a reduction in antibiotic consumption always represent a favorable outcome from an intervention program on prescribing practice?

2006 • 10 citations

Impact of a Clinical Pharmacist on Antibiotic Prescribing

1991 • 10 citations

Computer-assisted antimicrobial-use monitoring.

1986 • 10 citations

Predictors of Timely Antibiotic Administration for Patients Hospitalized With Community-Acquired Pneumonia From the Cluster-Randomized EDCAP Trial

2010 • 9 citations

Intervention to Discontinue Parenteral Antimicrobial Therapy in Hospitalized Patients with Urinary Tract Infection, Skin and Soft Tissue Infection, or No Evident Infection

1993 • 9 citations

La «intervención del tercer día»: análisis de los factores asociados al seguimiento de recomendaciones sobre la prescripción de antibióticos

2014 • 9 citations

Impact of a two-stage intervention program on cefazolin usage at a major teaching hospital.

1989 • 9 citations

Empirical management of community-acquired pneumonia: impact of concurrent A/H1N1 influenza pandemic on guideline implementation

2011 • 7 citations

Contribution of clinical pharmacists to cefazolin utilization.

1987 • 7 citations

The successful introduction of a programme to reduce the use of iv ciprofloxacin in hospital

2002 • 6 citations

Computer-assisted antimicrobial-use monitoring

1986 • 6 citations

The cost-effectiveness of clinical pharmacist intervention on tobramycin prescribing.

1986 • 5 citations

Cost Effectiveness of Antibacterial Restriction Strategies in a Tertiary Care University Teaching Hospital

2001 • 5 citations

Effect of academic detailing on the utilization of intravenous antimicrobial therapy

1993 • 5 citations

Antibiotikamanagement mittels Prokalzitoninspiegel

2010 • 3 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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Interventions to improve antibiotic prescribing practices for hospital inpatients (2013) – Cochrane database of systematic reviews | Metascience Observatory Explorer