Widespread expression of human alpha 1-antitrypsin in transgenic mice revealed by in situ hybridization.

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes

1984 • 1,638 citations

The mouse; its reproduction and development

1968 • 1,290 citations

Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.

1969 • 702 citations

Risk of Cirrhosis and Primary Liver Cancer in Alpha₁-Antitrypsin Deficiency

1986 • 582 citations

The house mouse. Development and normal stages from fertilization to 4 weeks of age.

1972 • 413 citations

The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency

1963 • 361 citations

Synthesis of Serum Albumin, Prealbumin, α-Foetoprotein, α1-Antitrypsin and Transferrin by the Human Yolk Sac

1970 • 280 citations

Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.

1988 • 236 citations

Two distinct factors interact with the promoter regions of several liver-specific genes.

1988 • 226 citations

Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages.

1985 • 204 citations

Cell-specific expression of a transfected human α1-antitrypsin gene

1985 • 188 citations

Lung injury induced by leukocytic proteases.

1979 • 183 citations

Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene.

1987 • 178 citations

Alpha-1-antitrypsin in human macrophages.

1981 • 175 citations

Multiple tissues express alpha 1-antitrypsin in transgenic mice and man.

1988 • 153 citations

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions

1984 • 135 citations

Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice.

1987 • 126 citations

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice

1987 • 117 citations

Alpha₁-Antitrypsin Deficiency and Emphysema Caused by Homozygous Inheritance of Non-Expressing Alpha₁-Antitrypsin Genes

1986 • 101 citations

Synthesis of plasma proteins in fetal, adult, and neoplastic human brain tissue

1986 • 80 citations

Morphological identification of alpha‐I‐antitrypsin in the human small intestine

1982 • 78 citations

Emphysema of Early Onset Associated with a Complete Deficiency of Alpha-1-Antitrypsin (null homozygotes)

1988 • 68 citations

Membranoproliferative glomerulonephritis in childhood cirrhosis associated with alpha1-antitrypsin deficiency.

1976 • 66 citations

Alpha1-antitrypsin deficiency, emphysema, necrotizing angiitis and glomerulonephritis

1969 • 60 citations

The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice

1987 • 56 citations

Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas

1977 • 51 citations

Aggregation of plasma Z type α₁‐antitrypsin suggests basic defect for the deficiency

1986 • 49 citations

Association of severe rheumatoid arthritis with heterozygosity for α‐antitrypsin deficiency

1980 • 46 citations

Isolation and Characterization of the α₁-Antitrypsin Gene of Mice

1986 • 45 citations

New variants of alpha 1-antitrypsin: comparison of Pi typing techniques.

1981 • 43 citations

Synthesis of alpha 1-anti-trypsin by human monocytes.

1983 • 40 citations

Alpha‐1‐antitrypsin immunoreactivity in gastric carcinoid

1982 • 34 citations

Cloning and characterization of an α1-antitrypsin like gene 12 kb downstream of the genuine α1-antitrypsin gene

1988 • 32 citations

Molecular structure and sequence homology of a gene related to α1-antitrypsin in the human genome

1988 • 31 citations

Organ cultures of human fetal hepatocytes in the study of extra- and intracellular α1-antitrypsin

1978 • 28 citations

α1-Antitrypsin Deficiency, Emphysema, Cirrhosis, and Intestinal Mucosal Atrophy

1975 • 28 citations

Immunohistochemical demonstration of alpha-1-antitrypsin in the islet cells of human pancreas

1978 • 27 citations

Necrotic panniculitis with α-1 antitrypsin deficiency

1986 • 25 citations

The human alpha‐1‐antitrypsin‐related sequence gene: isolation and investigation of its expression

1988 • 25 citations

alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.

1986 • 17 citations

Developmental expression, cellular localization, and testosterone regulation of alpha 1-antitrypsin in Mus caroli kidney.

1987 • 16 citations

Prevalence of alpha1-antitrypsin deficiency in patients with gastric or duodenal ulcer.

1974 • 15 citations

Islet-Cell Hyperplasia in Genetic Deficiency of Alpha-1 -Proteinase Inhibitor

1986 • 13 citations

In vitro synthesis of alpha-1-antitrypsin in long term monolayer human liver cell cultures.

1977 • 12 citations

Coeliac disease: alpha‐1‐antitrypsin contents in jejunal mucosa before and after gluten‐free diet

1984 • 9 citations

Alpha-1-antitrypsin associated liver disease in rheumatoid arthritis

1985 • 4 citations