Pharmacotherapy for Smoking Cessation: Present and Future

Mortality in relation to smoking: 40 years' observations on male British doctors

1994 • 5,782 citations

Treating tobacco use and dependence-Clinical practice guideline

2000 • 3,721 citations

Treating Tobacco Use and Dependence

2008 • 2,821 citations

Treating Tobacco Use and Dependence: 2008 Update

2009 • 2,528 citations

Nicotine replacement therapy for smoking cessation

2012 • 2,516 citations

Smoking and Mental Illness

2000 • 2,480 citations

Smoking and Carcinoma of the Lung

1950 • 1,909 citations

Physician advice for smoking cessation

2013 • 1,851 citations

Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 1,630 citations

Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 1,343 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Antidepressants for smoking cessation

2020 • 1,245 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Individual behavioural counselling for smoking cessation

2005 • 963 citations

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

2008 • 814 citations

Antidepressants for smoking cessation

2003 • 703 citations

Bupropion: a review of its mechanism of antidepressant activity.

1995 • 693 citations

Role of dopamine in the behavioural actions of nicotine related to addiction

2000 • 677 citations

Effect of Maintenance Therapy With Varenicline on Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 664 citations

Nicotine absorption and cardiovascular effects with smokeless tobacco use: Comparison with cigarettes and nicotine gum

1988 • 612 citations

Co‐Morbidity of Smoking in Patients with Psychiatric and Substance Use Disorders

2005 • 581 citations

Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

2006 • 534 citations

Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

1994 • 524 citations

Avoidable global cancer deaths and total deaths from smoking

2009 • 499 citations

Bupropion is a nicotinic antagonist.

2000 • 490 citations

Smoking Cessation With Varenicline, a Selective α4β2 Nicotinic Receptor Partial Agonist

2006 • 392 citations

A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence

2004 • 386 citations

Efficacy and Safety of the Novel Selective Nicotinic Acetylcholine Receptor Partial Agonist, Varenicline, for Smoking Cessation

2006 • 380 citations

Addressing tobacco among individuals with a mental illness or an addiction

2004 • 358 citations

Nicotine Transdermal Patch and Atypical Antipsychotic Medications for Smoking Cessation in Schizophrenia

2000 • 354 citations

A Systematic Review of Modafinil

2006 • 343 citations

Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial

2008 • 338 citations

Interventions for preventing weight gain after smoking cessation

2012 • 328 citations

Assessing motivation to quit smoking in people with mental illness: a review

2009 • 283 citations

Clonidine for smoking cessation

2004 • 247 citations

Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre, randomised study

2003 • 245 citations

Pregnancy outcome of women exposed to bupropion during pregnancy: A prospective comparative study

2005 • 233 citations

Use of drugs, alcohol and tobacco by people with schizophrenia: case–control study

2002 • 232 citations

Varenicline in the routine treatment of tobacco dependence: a pre–post comparison with nicotine replacement therapy and an evaluation in those with mental illness

2007 • 217 citations

Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database

2009 • 202 citations

Depression and smoking cessation: Characteristics of depressed smokers and effects of nicotine replacement.

1996 • 202 citations

Current pharmacological treatments for nicotine dependence

2003 • 182 citations

Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction

1999 • 174 citations

Analyzing milestones in smoking cessation: Illustration in a nicotine patch trial in adult smokers.

2006 • 167 citations

A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers*

1995 • 167 citations

Mediating mechanisms for the impact of bupropion in smoking cessation treatment

2002 • 153 citations

Monoamine oxidases and tobacco smoking

2001 • 147 citations

Psychiatric Adverse Events in Randomized, Double-Blind, Placebo-Controlled Clinical Trials of Varenicline

2010 • 146 citations

Monoamine oxidase A and B activities in heavy smokers

1995 • 140 citations

Effect of Nicotine Replacement on the Cigarette Withdrawal Syndrome

1984 • 134 citations

Combination Nicotine Replacement Therapy for Smoking Cessation

2001 • 128 citations

The use of bupropion SR in cigarette smoking cessation

2008 • 127 citations

Update on Pharmacologic Options for Smoking Cessation Treatment

2008 • 124 citations

Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation

2007 • 120 citations

Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy.

2007 • 118 citations

The efficacy and safety of varenicline for smoking cessation using a flexible dosing strategy in adult smokers: a randomized controlled trial

2008 • 113 citations

Varenicline versus bupropion SR or placebo for smoking cessation: a pooled analysis.

2008 • 112 citations

Use of Oral Topiramate to Promote Smoking Abstinence Among Alcohol-Dependent Smokers

2005 • 110 citations

A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation

2006 • 107 citations

Blocking cannabinoid CB₁ receptors for the treatment of nicotine dependence: insights from pre‐clinical and clinical studies

2008 • 106 citations

The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study

2009 • 105 citations

Neuropharmacology and potential efficacy of new treatments for tobacco dependence

2006 • 101 citations

Topiramate in the Treatment of Substance-Related Disorders

2010 • 101 citations

Dopamine D3 Receptor Ligands Block Nicotine-Induced Conditioned Place Preferences through a Mechanism that does not Involve Discriminative-Stimulus or Antidepressant-Like Effects

2004 • 101 citations

Varenicline and bupropion sustained-release combination therapy for smoking cessation

2009 • 99 citations

Smoking predicts suicidality: Findings from a prospective community study

2007 • 99 citations

Nicotine patch therapy prior to quitting smoking: a meta‐analysis

2008 • 98 citations

Management of smoking cessation in patients with psychiatric disorders

2009 • 98 citations

Advances in pharmacotherapy for tobacco dependence

2004 • 94 citations

The basal ganglia: anatomy, physiology, and pharmacology

2004 • 92 citations

Effects of gender on relapse prevention in smokers treated with bupropion SR

2002 • 87 citations

Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence

2009 • 81 citations

Tolerability and Safety of Sustained-Release Bupropion in the Management of Smoking Cessation

2002 • 81 citations

Combination treatment with varenicline and nicotine replacement therapy

2009 • 78 citations

Effectiveness of Bupropion for Smoking Cessation During Pregnancy

2005 • 77 citations

Efficacy and safety of bupropion for smoking cessation and reduction in schizophrenia: systematic review and meta-analysis

2010 • 75 citations

A Preliminary Benefit-Risk Assessment of Varenicline in Smoking Cessation

2009 • 74 citations

Varenicline for smoking cessation: efficacy, safety, and treatment recommendations

2010 • 64 citations

Vaccines against nicotine

2009 • 64 citations

Efficacy of bupropion and predictors of successful outcome in a sample of French smokers: a randomized placebo‐controlled trial

2004 • 64 citations

Preliminary evidence for gender‐specific effects of topiramate as a potential aid to smoking cessation

2008 • 60 citations

Pre‐cessation nicotine replacement therapy: pragmatic randomized trial

2010 • 57 citations

Bupropion for the treatment of nicotine withdrawal and craving

2006 • 56 citations

Novel Pharmacological Approaches for Treating Tobacco Dependence and Withdrawal

2008 • 55 citations

Comparison of Available Treatments for Tobacco Addiction

2010 • 53 citations

A Double-Blind Randomized Placebo-Controlled Pilot Study of Neuropsychiatric Adverse Events in Abstinent Smokers Treated with Varenicline or Placebo

2011 • 51 citations

Effects of topiramate or naltrexone on tobacco use among male alcohol-dependent outpatients

2009 • 51 citations

Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation

2002 • 47 citations

Smoking outcome by psychiatric history after behavioral and varenicline treatment

2010 • 47 citations

Health consequences of sustained smoking cessation

2009 • 43 citations

Differential Involvement of Glutamatergic Mechanisms in the Cognitive and Subjective Effects of Smoking

2008 • 43 citations

Monoamine Oxidase Inhibition for Tobacco Pharmacotherapy

2007 • 42 citations

A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers☆

2009 • 40 citations

What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy?

2009 • 40 citations

Varenicline: The newest agent for smoking cessation

2007 • 39 citations

Fluoxetine, smoking, and history of major depression: A randomized controlled trial.

2007 • 36 citations

Description of tobacco addiction in pregnant women

2005 • 36 citations

Effectiveness of pharmacologic therapy for smoking cessation in adolescent smokers: Meta-analysis of randomized controlled trials

2011 • 34 citations

Pharmacotherapy for Tobacco Dependence

2009 • 32 citations

A placebo-controlled trial of modafinil for nicotine dependence

2008 • 32 citations

Tolerability and pharmacokinetics of single and repeated doses of nicotine with The Straw, a novel nicotine replacement product

2004 • 30 citations

Management of emergent psychiatric symptoms during smoking cessation

2009 • 29 citations

An update on therapeutics for tobacco dependence

2007 • 27 citations

Comparison of the effects of a 24‐hour nicotine patch and a 16‐hour nicotine patch on smoking urges and sleep

2006 • 27 citations

A randomized, open‐label pilot comparison of gabapentin and bupropion SR for smoking cessation

2005 • 26 citations

Sleep effects of a 24-h versus a 16-h nicotine patch: A polysomnographic study during smoking cessation

2006 • 25 citations

Randomized, controlled, double-blind trial of taranabant for smoking cessation

2010 • 25 citations

Oral nicotine solution for smoking cessation: a pilot tolerability study

2001 • 23 citations

Dianicline, a Novel 4 2 Nicotinic Acetylcholine Receptor Partial Agonist, for Smoking Cessation: A Randomized Placebo-Controlled Clinical Trial

2010 • 23 citations

Treatments for nicotine addiction should be a top priority

2009 • 22 citations

Dependence on the nicotine gum in former smokers

2008 • 21 citations

Addiction to the nicotine gum in never smokers

2007 • 20 citations

Gabapentin for smoking cessation

2010 • 19 citations

Varenicline in smoking cessation

2010 • 19 citations

Gabapentin for smoking cessation: A preliminary investigation of efficacy

2007 • 18 citations

Novel Pharmacological Approaches to Drug Abuse Treatment

2009 • 18 citations

Treatment of comorbid tobacco use in people with serious mental illness.

2009 • 17 citations