Back to search

Environmental and Genetic Risk Factors for Childhood Leukemia: Appraising the Evidence

Data up to Jan 2025

Published2005
Citations209
References196

Total Citations Per Year

Abstract

References (196)

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995

1999 • 1,895 citations

ELECTRICAL WIRING CONFIGURATIONS AND CHILDHOOD CANCER

1979 • 1,642 citations

Causal Knowledge as a Prerequisite for Confounding Evaluation: An Application to Birth Defects Epidemiology

2002 • 1,311 citations

A Survey of Childhood Malignancies

1958 • 889 citations

Monographs on the Evaluation of Carcinogenic Risks to Humans

1991 • 845 citations

Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria.

1990 • 785 citations

A pooled analysis of magnetic fields and childhood leukaemia

2000 • 726 citations

CASE-CONTROL STUDY OF CHILDHOOD CANCER AND EXPOSURE TO 60-HZ MAGNETIC FIELDS

1988 • 714 citations

Prenatal origin of acute lymphoblastic leukaemia in children

1999 • 640 citations

Benzene and Leukemia

1987 • 604 citations

Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

1997 • 558 citations

MALIGNANT DISEASE IN CHILDHOOD AND DIAGNOSTIC IRRADIATION IN UTERO

1956 • 556 citations

A Pooled Analysis of Magnetic Fields, Wire Codes, and Childhood Leukemia

2000 • 514 citations

Folic acid deficiency and cancer: mechanisms of DNA instability

1999 • 436 citations

Cancer Surveillance Series: Recent Trends in Childhood Cancer Incidence and Mortality in the United States

1999 • 430 citations

Paternal Cigarette Smoking and the Risk of Childhood Cancer Among Offspring of Nonsmoking Mothers

1997 • 429 citations

Residential Exposure to Magnetic Fields and Acute Lymphoblastic Leukemia in Children

1997 • 419 citations

Prenatal X-Ray Exposure and Childhood Cancer<xref ref-type="fn" rid="fn1">2</xref><xref ref-type="fn" rid="fn2">3</xref>

1962 • 414 citations

EVIDENCE FOR AN INFECTIVE CAUSE OF CHILDHOOD LEUKAEMIA: COMPARISON OF A SCOTTISH NEW TOWN WITH NUCLEAR REPROCESSING SITES IN BRITAIN

1988 • 393 citations

Childhood Leukemias

1995 • 382 citations

Pesticides and childhood cancer.

1998 • 372 citations

Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models.

2000 • 371 citations

Speculations on the cause of childhood acute lymphoblastic leukemia.

1988 • 371 citations

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

2001 • 338 citations

Benzene and the Dose-Related Incidence of Hematologic Neoplasms in China

1997 • 335 citations

Higher Frequency of Glutathione S-Transferase Deletions in Black Children With Acute Lymphoblastic Leukemia

1997 • 310 citations

A population-based case-control study of childhood leukemia in shanghai

1988 • 295 citations

Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey

1975 • 292 citations

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

2002 • 285 citations

Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment Interactions

2000 • 275 citations

Molecular genetics, natural history and the demise of childhood leukaemia

1999 • 266 citations

Review of the epidemiologic literature on EMF and Health.

2001 • 257 citations

Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study

2001 • 250 citations

Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms

1999 • 245 citations

Distance-Weighted Traffic Density in Proximity to a Home Is a Risk Factor for Leukemia and Other Childhood Cancers

2000 • 241 citations

Childhood Leukemia and Parents' Occupational and Home Exposures<xref ref-type="fn" rid="FN2">2</xref>

1987 • 240 citations

Association of childhood cancer with factors related to pregnancy and birth

1999 • 235 citations

Epidemiology of Childhood Cancer

1999 • 231 citations

Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group.

1989 • 227 citations

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

2003 • 224 citations

Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group

1996 • 222 citations

Critical windows of exposure to household pesticides and risk of childhood leukemia.

2002 • 218 citations

A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.

1999 • 218 citations

Childhood Leukemia and Pesticides

1999 • 214 citations

Parental Alcohol Consumption, Cigarette Smoking, and Risk of Infant Leukemia: a Childrens Cancer Group Study

1996 • 213 citations

Leukemia and Non-Hodgkin's Lymphoma in Childhood and Exposure to Pesticides: Results of a Register-based Case-Control Study in Germany

2000 • 212 citations

An infectious etiology for common acute lymphoblastic leukemia in childhood?

1993 • 211 citations

Epidemiology of Childhood Cancer.

1999 • 203 citations

The risk profile of childhood leukaemia in Greece: a nationwide case-control study

1997 • 201 citations

Air Pollution from Traffic at the Residence of Children with Cancer

2001 • 201 citations

Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia

2004 • 196 citations

Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: A meta-analysis.

2000 • 190 citations

Prenatal Exposure to Parents' Smoking and Childhood Cancer

1991 • 190 citations

Home pesticide use and childhood cancer: a case-control study.

1995 • 188 citations

Association of childhood cancer with residential traffic density.

1989 • 185 citations

Risk of Childhood Leukemia Associated with Exposure to Pesticides and with Gene Polymorphisms

1999 • 183 citations

Incidence of Leukaemia after Exposure to Diagnostic Radiation in Utero

1960 • 183 citations

Parental occupation and childhood cancer: review of epidemiologic studies.

1990 • 171 citations

Prenatal and Neonatal Risk Factors for Childhood Lymphatic Leukemia

1995 • 167 citations

Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study

2003 • 166 citations

Childhood cancer and parental use of tobacco: deaths from 1971 to 1976

1997 • 160 citations

Occupation of father at time of birth of children dying of malignant diseases

1974 • 158 citations

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

2001 • 156 citations

Childhood cancer and parental use of tobacco: deaths from 1953 to 1955

1997 • 156 citations

A cohort study of cancer among benzene-exposed workers in China: Overall results

1996 • 151 citations

Leukemia among children in a suburban community

1963 • 149 citations

Diagnostic X-ray and ultrasound exposure and risk of childhood cancer

1994 • 147 citations

Parental occupational exposures and risk of childhood cancer.

1998 • 146 citations

An exploratory case-control study of brain tumors in children.

1989 • 145 citations

Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia

2004 • 145 citations

The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia

2001 • 144 citations

Parental Occupation and Other Environmental Factors in the Etiology of Leukemias and Non-Hodgkin'S Lymphomas in Childhood: A Case-Control Study

1990 • 142 citations

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children

2002 • 141 citations

Environmental Factors in the Etiology of Rhabdomyosarcoma in Childhood<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1982 • 137 citations

Preconception, intrauterine, and postnatal irradiation as related to leukemia.

1966 • 136 citations

Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study

2004 • 136 citations

Childhood and adult cancer after intrauterine exposure to ionizing radiation

1999 • 136 citations

Day-care, early common infections and childhood acute leukaemia: a multicentre French case–control study

2002 • 136 citations

Analysis of incidence of childhood cancer in the West Midlands of the United Kingdom in relation to proximity to main roads and petrol stations.

1999 • 135 citations

Incidence and risk factors for childhood brain tumors in the ILE DE France

1994 • 133 citations

Childhood cancer after prenatal exposure to diagnostic X-ray examinations in Britain

1990 • 131 citations

Childhood cancer incidence rates and hazardous air pollutants in California: an exploratory analysis.

2002 • 129 citations

An industry wide mortality study of chemical workers occupationally exposed to benzene. II. Dose response analyses.

1987 • 127 citations

Cured and broiled meat consumption in relation to childhood cancer: Denver, Colorado (United States)

1994 • 126 citations

Association of childhood leukaemia with factors related to the immune system

1999 • 125 citations

High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia

2002 • 124 citations

Childhood cancer and agricultural pesticide use: an ecologic study in California.

2002 • 124 citations

Childhood leukemia and road traffic: A population‐based case‐control study

2003 • 123 citations

Exposure to motor vehicle exhaust and childhood cancer

1998 • 122 citations

Prenatal and neonatal risk factors for childhood myeloid leukemia.

1995 • 120 citations

On the parental origin of de novo mutation in man.

1991 • 119 citations

Daycare attendance and risk of childhood acute lymphoblastic leukaemia

2002 • 118 citations

Paternal radiation exposure and leukaemia in offspring: the Ontario case-control study.

1993 • 115 citations

Review of the Epidemiologic Literature on EMF and Health

2001 • 115 citations

Agricultural pesticide use in California: pesticide prioritization, use densities, and population distributions for a childhood cancer study.

2001 • 115 citations

CHILDHOOD LEUKEMIA AND PARENTAL OCCUPATION

1985 • 115 citations

An update of mortality among chemical workers exposed to benzene.

1986 • 113 citations

Hazard proximities of childhood cancers in Great Britain from 1953-80.

1997 • 113 citations

Parental occupational exposure to hydrocarbons and risk of acute lymphocytic leukemia in offspring.

1999 • 112 citations

Leukemia, lymphoma, and multiple myeloma following selected medical conditions

1992 • 110 citations

Molecular genetics, natural history and the demise of childhood leukaemia

1999 • 110 citations

Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study

2003 • 108 citations

Determinants of recall and recall bias in studying drug and chemical exposure in pregnancy

1989 • 107 citations

Processed meats and risk of childhood leukemia (California, USA)

1994 • 107 citations

Benzene as a leukemogenic and carcinogenic agent

1985 • 105 citations

Critical Windows of Exposure for Children's Health: Cancer in Human Epidemiological Studies and Neoplasms in Experimental Animal Models

2000 • 103 citations

Pesticides and Childhood Cancer

1998 • 103 citations

Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group.

1993 • 102 citations

Residential Exposure to Traffic in California and Childhood Cancer

2004 • 102 citations

Parental cigarette smoking and the risk of acute leukemia in children

1999 • 102 citations

A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom.

1997 • 99 citations

Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia

2004 • 98 citations

Traffic Density and the Risk of Childhood Leukemia in a Los Angeles Case-Control Study

2002 • 98 citations

Prenatal irradiation and childhood cancer

1987 • 98 citations

THE RELATIONSHIP OF INTRA-UTERINE RADIATION TO SUBSEQTJENT MORTALITY AND DEVELOPMENT OF LEUKEMIA IN CHILDREN

1973 • 97 citations

Agricultural Pesticide Use and Childhood Cancer in California

2004 • 96 citations

Maternal Smoking in Pregnancy: Does it Increase the Risk of Childhood Cancer?

1992 • 96 citations

Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)

2004 • 95 citations

Maternal Herpesvirus Infections and Risk of Acute Lymphoblastic Leukemia in the Offspring

2003 • 92 citations

Parental occupations of children with leukaemia in west Cumbria, north Humberside, and Gateshead.

1991 • 92 citations

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis

2002 • 91 citations

An industry wide mortality study of chemical workers occupationally exposed to benzene. I. General results.

1987 • 89 citations

Occupational case‐control studies: I. Collecting information on work histories and work‐related exposures

1994 • 89 citations

Childhood cancer and parental use of alcohol and tobacco

1995 • 87 citations

An exploratory study of environmental and medical factors potentially related to childhood cancer

1991 • 85 citations

Bias in Studies of Parental Self-reported Occupational Exposure and Childhood Cancer

2003 • 85 citations

Molecular genetics in acute leukemia

2000 • 84 citations

Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children

1994 • 84 citations

Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada).

2000 • 84 citations

Associations between childhood cancer and ionizing radiation: results of a population-based case-control study in Germany.

1999 • 82 citations

Genetic polymorphisms of N-acetyltransferases 1 and 2 and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia.

2000 • 81 citations

Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California

2003 • 80 citations

Control Selection Strategies in Case-Control Studies of Childhood Diseases

2004 • 79 citations

Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group.

1994 • 79 citations

Allergic disorders and the risk of childhood acute lymphoblastic leukemia (United States).

2000 • 78 citations

Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201

2002 • 78 citations

Review of Reported Increases of Childhood Cancer Rates in the Vicinity of Nuclear Installations in the UK

1989 • 77 citations

Risk of childhood leukemia and parental self-reported occupational exposure to chemicals, dusts, and fumes: results from pooled analyses of German population-based case-control studies.

2000 • 73 citations

Household solvent exposures and childhood acute lymphoblastic leukemia

2001 • 73 citations

Traffic patterns and childhood cancer incidence rates in California, United States.

2002 • 73 citations

Cancer in the offspring of fathers in hydrocarbon-related occupations.

1976 • 72 citations

Molecular Genetics of Cancer Susceptibility

2000 • 71 citations

Glutathione S-transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukaemia

2002 • 70 citations

Do Confounding or Selection Factors of Residential Wiring Codes and Magnetic Fields Distort Findings of Electromagnetic Fields Studies?

2000 • 67 citations

Environmental exposure to gasoline and leukemia in children and young adults-an ecology study

1997 • 67 citations

Childhood leukaemia and exposure to pesticides: Results of a case-control study in Northern Germany

1996 • 66 citations

Occupational case‐control studies: II. Recommendations for exposure assessment

1994 • 65 citations

Childhood Cancer in Relation to Cured Meat Intake: Review of the Epidemiological Evidence

1999 • 65 citations

CANCER IN CHILDREN OF PARENTS EXPOSED TO HYDROCARBON-RELATED INDUSTRIES AND OCCUPATIONS

1980 • 63 citations

A Descriptive Epidemiology of Sport and Recreation Injuries in a Population-Based Sample: Results from the Alberta Sport and Recreation Injury Survey (ASRIS)

1998 • 62 citations

MATERNAL SMOKING DURING PREGNANCY AND THE RISK OF CHILDHOOD CANCER

1986 • 61 citations

Issues in Performing Retrospective Exposure Assessment

1991 • 61 citations

Acute myeloid leukaemia in one of identical twins

1937 • 59 citations

Childhood leukemia: electric and magnetic fields as possible risk factors.

2003 • 59 citations

Childhood Cancer and Population Mixing

2003 • 57 citations

Selection bias from differential residential mobility as an explanation for associations of wire codes with childhood cancer

1993 • 56 citations

Food Consumption by Children and the Risk of Childhood Acute Leukemia

2004 • 56 citations

Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children.

1994 • 53 citations

An epidemiological study of petroleum refinery employees.

1986 • 53 citations

DIAGNOSTIC X RAYS, DNA REPAIR GENES AND CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

2003 • 52 citations

Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia

2003 • 52 citations

Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility in childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology

1998 • 52 citations

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

2003 • 52 citations

Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia

2003 • 50 citations

Excess leukemia in a refinery population.

1985 • 50 citations

Mechanisms of carcinogenesis : contributions of molecular epidemiology

2004 • 46 citations

The Occupational Questionnaire in Retrospective Epidemiologic Studies: Recent Approaches in Community-Based Studies

1991 • 46 citations

Maternal Smoking During Pregnancy and Childhood Cancer

1996 • 45 citations

Acute myelocytic leukemia and prior allergies

1989 • 44 citations

The glutathione S-transferase mu polymorphism and susceptibility to acute lymphocytic leukemia

2000 • 42 citations

CHILDHOOD CANCER OCCURRENCE IN RELATION TO POWER LINE CONFIGURATIONS

1995 • 42 citations

Evidence on the infectious etiology of childhood leukemia: the role of low herd immunity (Greece).

2001 • 39 citations

Childhood cancer and environmental contaminants.

1998 • 38 citations

Leukaemia clusters in childhood: geographical analysis in Britain.

1994 • 38 citations

Metabolism of xenobiotics and chemical carcinogenesis.

1999 • 35 citations

Childhood leukaemia incidence and the population mixing hypothesis in US SEER data

2004 • 34 citations

Leukaemia and non-Hodgkin's lymphoma: incidence in children and young adults resident in the Dounreay area of Caithness, Scotland in 1968-91.

1994 • 33 citations

PRENATAL X-RAY AND CHILDHOOD CANCER: A REVIEW.

1964 • 33 citations

Factors that explain the power line configuration wiring code-childhood leukemia association: What would they look like?

2001 • 31 citations

Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.

1995 • 30 citations

Childhood leukemia incidence in the vicinity of La Hague nuclear-waste reprocessing facility (France)

1993 • 30 citations

Molecular analysis of HLA-DQB1 alleles in childhood common acute lymphoblastic leukaemia

1996 • 27 citations

The Assessment of Risk of Radiation-Induced Childhood Leukaemia in the Vicinity of Nuclear Installations

1989 • 24 citations

CANCER MORTALITY IN COUNTIES NEAR TWO FORMER NUCLEAR MATERIALS PROCESSING FACILITIES IN PENNSYLVANIA, 1950–1995

2003 • 23 citations

CHILDHOOD LEUKEMIA NEAR NUCLEAR PLANTS IN THE UNITED KINGDOM: THE EVOLUTION OF A SYSTEMATIC APPROACH TO STUDYING RARE DISEASE IN SMALL GEOGRAPHIC AREAS

1990 • 22 citations

Association of Parents' Occupational Exposure to Cancer in Children. A Case-control Study of Acute Lymphoblastic Leukemia.

1993 • 19 citations

Prenatal smoking in two consecutive pregnancies: Georgia, 1989-1992.

1997 • 19 citations

Oxford Survey of Childhood Cancers: progress report. IV. Reliability of data reported by case and control mothers.

1966 • 19 citations

HPA-RPD (formerly National Radiological Protection Board) Report of an independent Advisory Group on Non-ionising Radiation: Power Frequency Electromagnetic Fields, Melatonin and the Risk of Breast Cancer -

2006 • 18 citations

The Relative Merits of Contemporary Measurements and Historical Calculated Fields in the Swedish Childhood Cancer Study

2000 • 12 citations

Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

2003 • 11 citations

Childhood leukaemia and non-Hodgkin's lymphoma in relation to proximity to railways

2003 • 10 citations

Development and evaluation of parental occupational exposure questionnaires for a childhood leukemia study

2004 • 6 citations

Description of a new computer wire coding method and its application to evaluate potential control selection bias in the Savitz et al. childhood cancer study

2000 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

No citing papers found in database

Environmental and Genetic Risk Factors for Childhood Leukemia: Appraising the Evidence (2005) – Cancer Investigation | Metascience Observatory Explorer