Tumor Stromal-Derived Factor-1 Recruits Vascular Progenitors to Mitotic Neovasculature, where Microenvironment Influences Their Differentiated Phenotypes

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization

1999 • 3,280 citations

Exploiting tumour hypoxia in cancer treatment

2004 • 2,606 citations

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

2001 • 2,583 citations

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

2004 • 2,534 citations

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

1999 • 2,425 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

2001 • 1,999 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells

1999 • 1,852 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 1,666 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

In vitro differentiation of endothelial cells from AC133-positive progenitor cells

2000 • 1,001 citations

Molecular mechanisms of blood vessel growth

2001 • 999 citations

Transplanted cord blood–derived endothelial precursor cells augment postnatal neovascularization

2000 • 908 citations

Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature

2003 • 605 citations

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

2003 • 557 citations

Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines

2002 • 518 citations

SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

2004 • 517 citations

Contribution of bone marrow–derived endothelial cells to human tumor vasculature

2005 • 490 citations

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

2004 • 430 citations

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

2000 • 420 citations

CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers

2005 • 407 citations

The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells

2003 • 399 citations

The hypoxic response of tumors is dependent on their microenvironment

2003 • 396 citations

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

2004 • 395 citations

Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.

2000 • 371 citations

Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.

2003 • 337 citations

Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

2000 • 298 citations

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

2004 • 284 citations

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors

2003 • 245 citations

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

1997 • 226 citations

Studies on the chemotherapy of experimental brain tumors: development of an experimental model.

1970 • 221 citations

Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice.

2001 • 199 citations

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis Attenuates In vivo Tumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

2005 • 185 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 129 citations

Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras

1999 • 128 citations

SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion

2005 • 115 citations

Minor Contribution of Bone Marrow‐Derived Endothelial Progenitors to the Vascularization of Murine Gliomas

2003 • 113 citations

Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.

1995 • 104 citations

Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model1

2004 • 83 citations

Contribution of Bone Marrow-Derived Cells to Blood Vessels in Ischemic Tissues and Tumors

2005 • 79 citations

Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression

2000 • 76 citations

Efficacious immunomodulatory activity of the chemokine stromal cell–derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell–dependent antitumor responses

2002 • 71 citations

Human Cord Blood Progenitors Sustain Thymic T-Cell Development and a Novel Form of Angiogenesis

1999 • 64 citations

PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli.

2003 • 54 citations

Circulating vascular endothelial growth factor in cutaneous malignant melanoma

2005 • 40 citations