Activation of the RAS/Cyclic AMP Pathway Suppresses a TOR Deficiency in Yeast

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Current protocols in molecular biology

1988 • 7,584 citations

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1998 • 5,253 citations

Getting started with yeast

2002 • 3,496 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

[1] Getting started with yeast

1991 • 2,456 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

The economics of ribosome biosynthesis in yeast

1999 • 1,869 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

2000 • 1,105 citations

The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).

1996 • 1,050 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

1998 • 759 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

Function and Regulation of Yeast Hexose Transporters

1999 • 705 citations

Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae

1999 • 660 citations

The TOR signaling cascade regulates gene expression in response to nutrients

1999 • 593 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.

1987 • 504 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae.

1996 • 476 citations

Preparation of Yeast RNA

1993 • 437 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway inSaccharomyces cerevisiae

1999 • 378 citations

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

2002 • 357 citations

Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation

1998 • 356 citations

A Saccharomyces cerevisiae G‐protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose

1999 • 350 citations

The TOR Kinases Link Nutrient Sensing to Cell Growth

2001 • 348 citations

Novel System for Monitoring Autophagy in the Yeast Saccharomyces cerevisiae

1995 • 344 citations

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1999 • 339 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

2002 • 326 citations

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1998 • 308 citations

GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras-independent pathway

1998 • 302 citations

Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor

2002 • 296 citations

Starvation Induces Vacuolar Targeting and Degradation of the Tryptophan Permease in Yeast

1999 • 289 citations

cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae

1988 • 270 citations

Msn2p and Msn4p Control a Large Number of Genes Induced at the Diauxic Transition Which Are Repressed by Cyclic AMP in Saccharomyces cerevisiae

1998 • 269 citations

The G Protein-Coupled Receptor Gpr1 Is a Nutrient Sensor That Regulates Pseudohyphal Differentiation in Saccharomyces cerevisiae

2000 • 248 citations

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

2000 • 236 citations

TIP41 Interacts with TAP42 and Negatively Regulates the TOR Signaling Pathway

2001 • 235 citations

Tor Kinases Are in Distinct Membrane-associated Protein Complexes inSaccharomyces cerevisiae

2003 • 233 citations

Tripartite Regulation of Gln3p by TOR, Ure2p, and Phosphatases

2000 • 228 citations

Mechanism of Metabolic Control

2000 • 220 citations

Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase

1998 • 218 citations

Rapamycin Induces the G₀ Program of Transcriptional Repression in Yeast by Interfering with the TOR Signaling Pathway

1998 • 214 citations

Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1

2000 • 209 citations

RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway

1991 • 205 citations

A search in the genome ofSaccharomyces cerevisiae for genes regulated via stress response elements

1998 • 204 citations

Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase.

1989 • 199 citations

The TOR Signal Transduction Cascade Controls Cellular Differentiation in Response to Nutrients

2001 • 165 citations

The Npr1 Kinase Controls Biosynthetic and Endocytic Sorting of the Yeast Gap1 Permease

2001 • 162 citations

Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.

1994 • 162 citations

Multiple Roles of Tap42 in Mediating Rapamycin-Induced Transcriptional Changes in Yeast

2003 • 156 citations

Cloning and Characterization of BCY1, a Locus Encoding a Regulatory Subunit of the Cyclic AMP-Dependent Protein Kinase in Saccharomyces cerevisiae

1987 • 151 citations

Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal

2001 • 146 citations

[30] Labeling of RNA and phosphoproteins in Saccharomyces cerevisiae

1991 • 116 citations

RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p

2001 • 110 citations

Nutritional Control of Nucleocytoplasmic Localization of cAMP-dependent Protein Kinase Catalytic and Regulatory Subunits in Saccharomyces cerevisiae

2000 • 107 citations

Nutrient Availability and the RAS/Cyclic AMP Pathway Both Induce Expression of Ribosomal Protein Genes in Saccharomyces cerevisiae but by Different Mechanisms

1995 • 104 citations

Molecular mechanisms controlling the localisation of protein kinase A

2002 • 104 citations

The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

1998 • 97 citations

Protein Kinase A Mediates Growth-Regulated Expression of Yeast Ribosomal Protein Genes by Modulating RAP1 Transcriptional Activity

1994 • 68 citations

Regulation of APG14 Expression by the GATA-type Transcription Factor Gln3p

2001 • 67 citations

Mammalian Target of Rapamycin and Protein Kinase A Signaling Mediate the Cardiac Transcriptional Response to Glutamine

2003 • 67 citations

Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene.

1994 • 53 citations

Suppression of a Yeast Cyclic AMP-Dependent Protein Kinase Defect by Overexpression of SOK1, a Yeast Gene Exhibiting Sequence Similarity to a Developmentally Regulated Mouse Gene

1994 • 19 citations