DNA Topology-Mediated Control of Global Gene Expression in Escherichia coli

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

1987 • 4,385 citations

Escherichia coli and Salmonella typhimurium: Cellular and molecular biology

1988 • 3,957 citations

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

DNA gyrase, topoisomerase IV, and the 4-quinolones

1997 • 1,249 citations

MOLECULAR BIOLOGY OF THE LysR FAMILY OF TRANSCRIPTIONAL REGULATORS

1993 • 1,040 citations

A Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase

1993 • 790 citations

Adenylate Energy Charge inEscherichia coliDuring Growth and Starvation

1971 • 772 citations

A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli

1988 • 719 citations

DNA Gyrase and the Supercoiling of DNA

1980 • 713 citations

Induction of proteins in response to low temperature in Escherichia coli

1987 • 599 citations

A large family of bacterial activator proteins.

1988 • 559 citations

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

1980 • 519 citations

E. coli DNA binding protein HU forms nucleosome-like structure with circular double-stranded DNA

1979 • 459 citations

Regulation of the genes for E. coli DNA gyrase: Homeostatic control of DNA supercoiling

1983 • 458 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

The cold‐shock response — a hot topic

1994 • 437 citations

The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli

1994 • 399 citations

Escherichia coli DNA topoisomerase I mutants: Increased supercoiling is corrected by mutations near gyrase genes

1982 • 376 citations

REGULATION OF ENZYME FUNCTION

1969 • 374 citations

Control of bacterial DNA supercoiling

1992 • 372 citations

Inhibitors of DNA topoisomerases

1988 • 340 citations

Roles of Topoisomerases in Maintaining Steady-state DNA Supercoiling in Escherichia coli

2000 • 326 citations

Use of site-specific recombination as a probe of DNA structure and metabolism in vivo

1987 • 297 citations

Identification of an UP element consensus sequence for bacterial promoters

1998 • 295 citations

Topology and Formation of Triple-Stranded H-DNA

1989 • 279 citations

Understanding DNA: The Molecule and How It Works

1992 • 276 citations

Biological Feedback Control at the Molecular Level

1965 • 250 citations

Adenine Nucleotide Concentrations and Turnover Rates. Their Correlation with Biological Activity in Bacteria and Yeast

1977 • 234 citations

Multiple Single-Stranded cis Elements Are Associated with Activated Chromatin of the Human c-myc Gene In Vivo

1996 • 223 citations

Stabilization of Z DNA in Vivo by Localized Supercoiling

1989 • 220 citations

Bacterial DNA supercoiling and [ATP]/[ADP] ratio: changes associated with salt shock

1991 • 202 citations

Understanding DNA: The molecule and how it works

1994 • 197 citations

Promoter Selectivity of Escherichia coli RNA Polymerase Eσ70 and Eσ38 Holoenzymes

1996 • 186 citations

Thermal denaturation of double-stranded nucleic acids: prediction of temperatures critical for gradient gel electrophoresis and polymerase chain reaction

1994 • 182 citations

Histone-like proteins in the purified Escherichia coli deoxyribonucleoprotein

1977 • 176 citations

Stable DNA unwinding, not "breathing," accounts for single-strand-specific nuclease hypersensitivity of specific A+T-rich sequences.

1988 • 165 citations

Biosynthesis of the Branched-Chain Amino Acids

2014 • 143 citations

Negative supercoiling induces spontaneous unwinding of a bacterial promoter.

1985 • 141 citations

Supercoils in prokaryotic DNA restrained in vivo.

1980 • 133 citations

Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions

1997 • 133 citations

Regulation of theEscherichia coliDNA topoisomerase I gene by DNA supercolling

1985 • 131 citations

Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12.

1980 • 130 citations

Torsional stress and local denaturation in supercoiled DNA.

1979 • 119 citations

DNA twist as a transcriptional sensor for environmental changes

1992 • 117 citations

Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters.

1986 • 111 citations

Duplex Destabilization in Superhelical DNA is Predicted to Occur at Specific Transcriptional Regulatory Regions

1996 • 109 citations

Genetic analysis of mutations that compensate for loss of Escherichia coli DNA topoisomerase I

1985 • 106 citations

Energetics of the strand separation transition in superhelical DNA

1992 • 104 citations

Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli

1988 • 103 citations

Topoisomerase IV, alone, unknots DNA in E. coli

2001 • 101 citations

Sites of predicted stress-induced DNA duplex destabilization occur preferentially at regulatory loci.

1993 • 100 citations

Nucleotide sequence of ilvGEDA operon attenuator region of Escherichia coli.

1980 • 99 citations

Localization of the HU Protein on the Escherichia coli Nucleoid

1978 • 99 citations

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.

1996 • 99 citations

Activation of Gene Expression by a Novel DNA Structural Transmission Mechanism That Requires Supercoiling-induced DNA Duplex Destabilization in an Upstream Activating Sequence

1998 • 98 citations

leu operon of Salmonella typhimurium is controlled by an attenuation mechanism.

1979 • 97 citations

Supercoiling response of the lac ps promoter in vitro

1985 • 96 citations

DNA supercoiling by DNA gyrase

1988 • 96 citations

Multiple promoters for transcription of the Escherichia coli DNA topoisomerase I gene and their regulation by DNA supercoiling

1988 • 91 citations

Escherichia coli DNA topoisomerase III: purification and characterization of a new type I enzyme

1984 • 88 citations

Molecular anatomy of a transcription activation patch: FIS-RNA polymerase interactions at the Escherichia coli rrnB P1 promoter

1997 • 85 citations

Exact method for numerically analyzing a model of local denaturation in superhelically stressed DNA

1999 • 81 citations

Supercoil-induced extrusion of a regulatory DNA hairpin

1997 • 81 citations

DNA supercoiling in vivo

1988 • 80 citations

Cross-talk Between Topoisomerase I and HU inEscherichia coli

1996 • 79 citations

Both fis-dependent and factor-independent upstream activation of the rrnB P1 promoter are face of the helix dependent

1992 • 79 citations

The twisted ‘life’ of DNA in the cell: bacterial topoisomerases

1995 • 78 citations

The Transcriptional Activator Protein FIS: DNA Interactions and Cooperative Interactions with RNA Polymerase at theEscherichia coli rrnBP1 Promoter

1995 • 78 citations

Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP.

1982 • 77 citations

DNA supercoiling allows enhancer action over a large distance

2001 • 76 citations

Transcriptional coupling between the divergent promoters of a prototypic LysR-type regulatory system, the ilvYC operon of Escherichia coli

1999 • 75 citations

DNA binding and bending are necessary but not sufficient for Fis-dependent activation of rrnB P1

1993 • 66 citations

FIS activates sequential steps during transcription initiation at a stable RNA promoter

1997 • 65 citations

Localized domains of DNA supercoiling: topological coupling between promoters

1996 • 60 citations

Topoisomerase mutations affect the relative abundance of many Escherichia coli proteins

1993 • 60 citations

Analysis of the Fis-dependent and Fis-independent transcription activation mechanisms of the Escherichia coli ribosomal RNA P1 promoter

1992 • 57 citations

DNA supercoiling‐dependent transcriptional coupling between the divergently transcribed promoters of the ilvYC operon of Escherichia coli is proportional to promoter strengths and transcript lengths

2001 • 54 citations

Energy buffering of DNA structure fails when Escherichia coli runs out of substrate

1995 • 50 citations

Theoretical analysis of heteropolymeric transitions in superhelical DNA molecules of specified sequence

1990 • 48 citations

Reduced 4,5',8-trimethylpsoralen cross-linking of left-handed Z-DNA stabilized by DNA supercoiling

1987 • 44 citations

DNA structure and transcription

1999 • 43 citations

Inhibition of DNA Supercoiling-dependent Transcriptional Activation by a Distant B-DNA to Z-DNA Transition

1999 • 41 citations

Activation of Gene Expression by a Ligand-induced Conformational Change of a Protein-DNA Complex

1998 • 40 citations

Nucleotide sequence of theilvB multivalent attenuator region ofEscherichia coliK12

1983 • 37 citations

The effects of DNA supercoiling on the expression of operons of the ilv regulon of Escherichia coli suggest a physiological rationale for divergently transcribed operons

2001 • 33 citations

Control of DNA structure and gene expression.

1990 • 32 citations

Theoretical analysis of transitions between B- and Z-conformations in torsionally stressed DNA

1980 • 32 citations

Effects of Integration Host Factor and DNA Supercoiling on Transcription from the ilvPG Promoter of Escherichia coli

1996 • 30 citations

Characterization of the integration host factor binding site in the ilvPG1 promoter region of the ilvGMEDA operon of Escherichia coli.

1990 • 29 citations

Mechanisms of upstream activation of the rrnD promoter P1 of Escherichia coli

1993 • 28 citations

Activation of Escherichia coli leuV Transcription by FIS

1999 • 25 citations

Expression of the recA gene is reduced in Escherichia coli topoisomerase I mutants

1990 • 24 citations

Activation and repression of transcription initiation by a distant DNA structural transition

2001 • 24 citations

Multiple Mechanisms Are Used for Growth Rate and Stringent Control of leuV Transcriptional Initiation in Escherichia coli

1999 • 21 citations

Altered topoisomerase activities may be involved in the regulation of DNA supercoiling in aerobic-anaerobic transitions inEscherichia coli

1993 • 19 citations

Regulation of DNA supercoiling in Escherichia coli: Genetic basis of a compensatory mutation in DNA gyrase

1989 • 17 citations

An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein

1992 • 13 citations

Monte Carlo analysis of conformational transitions in superhelical DNA

1995 • 13 citations

Escherichia coli DNA Topoisomerase I Mutants Have Compensatory Mutations at or near DNA Gyrase Genes

1983 • 10 citations

The effects of DNA supercoiling on the expression of operons of the ilv regulon of Escherichia coli suggest a physiological rationale for divergently transcribed operons

2001 • 5 citations