Long-Term Subclinical Carrier State Precedes Scrapie Replication and Adaptation in a Resistant Species: Analogies to Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease in Humans

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 • 1,740 citations

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

1996 • 857 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Bovine spongiform encephalopathy: epidemiological studies.

1988 • 721 citations

Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy

1994 • 663 citations

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 • 517 citations

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1992 • 440 citations

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

1991 • 385 citations

Strain-dependent Differences in β-Sheet Conformations of Abnormal Prion Protein

1998 • 313 citations

Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease

2000 • 300 citations

Species-barrier-independent prion replication in apparently resistant species

2000 • 293 citations

Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

1978 • 250 citations

The Genomic Identity of Different Strains of Mouse Scrapie Is Expressed in Hamsters and Preserved on Reisolation in Mice

1989 • 222 citations

Scrapie Infectivity and Proteinase K‐Resistant Prion Protein in Sheep Placenta, Brain, Spleen, and Lymph Node: Implications for Transmission and Antemortem Diagnosis

1998 • 195 citations

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent

1995 • 155 citations

Bovine spongiform encephalopathy: epidemiological features 1985 to 1990

1992 • 144 citations

The Host Range of Chronic Wasting Disease Is Altered on Passage in Ferrets

1998 • 142 citations

Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains

1986 • 137 citations

Molecular screening of sheep for bovine spongiform encephalopathy

1998 • 87 citations

Prion Protein and the Transmissible Spongiform Encephalopathy Diseases

1999 • 75 citations

Pathogenesis of Scrapie: Agent Multiplication in Brain at the First and Second Passage of Hamster Scrapie in Mice

1979 • 51 citations

EVIDENCE THAT TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT IS BIOLOGICALLY INACTIVE IN MICE

1986 • 34 citations

Transmission studies of BSE in cattle, hamsters, pigs and domestic fowl.

1991 • 18 citations