Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

1995 • 1,195 citations

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

1995 • 610 citations

Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

2000 • 403 citations

Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

1995 • 400 citations

Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

1976 • 388 citations

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

2001 • 383 citations

Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity

2000 • 367 citations

Structural basis for activation of the titin kinase domain during myofibrillogenesis

1998 • 355 citations

Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle

2001 • 329 citations

Muscle assembly: a titanic achievement?

1999 • 323 citations

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

1995 • 314 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Titin Develops Restoring Force in Rat Cardiac Myocytes

1996 • 250 citations

Titin-Based Modulation of Calcium Sensitivity of Active Tension in Mouse Skinned Cardiac Myocytes

2001 • 248 citations

I-Band Titin in Cardiac Muscle Is a Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure

1999 • 237 citations

Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin

1997 • 230 citations

Myosin Binding Protein C, a Phosphorylation-Dependent Force Regulator in Muscle That Controls the Attachment of Myosin Heads by Its Interaction With Myosin S2

2000 • 223 citations

Changes in Titin and Collagen Underlie Diastolic Stiffness Diversity of Cardiac Muscle

2000 • 211 citations

Beta-adrenergic receptor stimulation increases unloaded shortening velocity of skinned single ventricular myocytes from rats.

1994 • 198 citations

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

2001 • 187 citations

cAPK‐phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin‐S2 in an on‐off fashion

1999 • 185 citations

Length Dependence of Tension Generation in Rat Skinned Cardiac Muscle

2001 • 180 citations

Mechanically Driven Contour-Length Adjustment in Rat Cardiac Titin’s Unique N2B Sequence

1999 • 165 citations

Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases.

1984 • 155 citations

Protein Kinase A Does Not Alter Economy of Force Maintenance in Skinned Rat Cardiac Trabeculae

1995 • 140 citations

Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics

1996 • 115 citations

Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction

1997 • 113 citations

Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.

1993 • 111 citations

Cardiac Myosin-Binding Protein C (MyBP-C): Identification of Protein Kinase A and Protein Kinase C Phosphorylation Sites

1998 • 97 citations

Molecular Dissection of N2B Cardiac Titin’s Extensibility

1999 • 91 citations

Effects of phosphorylation of troponin I and C protein on isometric tension and velocity of unloaded shortening in skinned single cardiac myocytes from rats.

1994 • 88 citations

The amino acid sequence of rabbit cardiac troponin I

1976 • 87 citations

Characterization of a 5.4 kb cDNA fragment from the Z-line region of rabbit cardiac titin reveals phosphorylation sites for proline-directed kinases

1995 • 63 citations

Beta-adrenergic modulation of currents produced by rat cardiac Na+ channels expressed in Xenopus laevis oocytes.

1994 • 56 citations

In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis

1997 • 43 citations

Effect of Troponin I Phosphorylation by Protein Kinase A on Length-Dependence of Tension Activation in Skinned Cardiac Muscle Fibers

2000 • 33 citations

In vivo phosphorylation of titin and nebulin in frog skeletal muscle

1987 • 31 citations

Dephosphorylation of cardiac myofibril C-protein by protein phosphatase 1 and protein phosphatase 2A

1987 • 26 citations

Protein Kinase A Increases the Tension Cost and Unloaded Shortening Velocity in Skinned Rat Cardiac Muscle

1997 • 20 citations