Biomarkers in diabetic nephropathy: Present and future

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

2017 • 28,714 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

A New Equation to Estimate Glomerular Filtration Rate

2009 • 21,756 citations

Global Prevalence of Diabetes

2004 • 15,420 citations

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Differential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach

2013 • 4,230 citations

Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children

2016 • 3,967 citations

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

2008 • 3,396 citations

Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes

1984 • 1,939 citations

Diabetic Nephropathy: Diagnosis, Prevention, and Treatment

2005 • 1,717 citations

Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts

1992 • 1,549 citations

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD

2014 • 1,544 citations

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

2015 • 1,504 citations

Albuminuria reflects widespread vascular damage

1989 • 1,390 citations

Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

2004 • 1,361 citations

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

1997 • 1,246 citations

Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

1999 • 1,054 citations

Estimating GFR Using Serum Cystatin C Alone and in Combination With Serum Creatinine: A Pooled Analysis of 3,418 Individuals With CKD

2008 • 997 citations

Familial Clustering of Diabetic Kidney Disease

1989 • 991 citations

Alpha-1-acid glycoprotein

2000 • 961 citations

Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics

2003 • 928 citations

Albuminuria and Kidney Function Independently Predict Cardiovascular and Renal Outcomes in Diabetes

2009 • 874 citations

Regression of Microalbuminuria in Type 1 Diabetes

2003 • 783 citations

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

2011 • 742 citations

Cystatin C: An Improved Estimator of Glomerular Filtration Rate?

2002 • 663 citations

Cytokine and Cytokine-Like Inflammation Markers, Endothelial Dysfunction, and Imbalanced Coagulation in Development of Diabetes and Its Complications

2009 • 613 citations

Renal Insufficiency in the Absence of Albuminuria and Retinopathy Among Adults With Type 2 Diabetes Mellitus

2003 • 595 citations

Relationship between Oxidative Stress and Inflammatory Cytokines in Diabetic Nephropathy

2010 • 587 citations

Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size

2010 • 582 citations

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

2014 • 549 citations

Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage

2008 • 541 citations

The missing link: A single unifying mechanism for diabetic complications

2000 • 517 citations

Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate

1994 • 514 citations

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

2010 • 485 citations

Tubular kidney injury molecule‐1 (KIM‐1) in human renal disease

2007 • 442 citations

Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes

2012 • 427 citations

Circulating TNF Receptors 1 and 2 Predict Stage 3 CKD in Type 1 Diabetes

2012 • 329 citations

Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration

2005 • 327 citations

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

2010 • 296 citations

Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients

2002 • 290 citations

Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

2009 • 289 citations

Acute-Phase Markers of Inflammation and Glomerular Structure in Patients with Type 2 Diabetes

2005 • 286 citations

In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria

2009 • 276 citations

Glomerular Structure in Nonproteinuric IDDM Patients With Various Levels of Albuminuria

1994 • 276 citations

Urinary Proteomics in Diabetes and CKD

2008 • 273 citations

New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes

2012 • 263 citations

Adult reference ranges for serum cystatin C, creatinine and predicted creatinine clearance

2000 • 257 citations

Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy

2012 • 250 citations

Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus

2003 • 237 citations

Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials

2013 • 225 citations

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase

2010 • 220 citations

Urinary Excretion of Fatty Acid-Binding Protein Reflects Stress Overload on the Proximal Tubules

2004 • 216 citations

Urine Biomarkers Predict the Cause of Glomerular Disease

2007 • 215 citations

Oxidative DNA damage in diabetes mellitus: its association with diabetic complications

1999 • 207 citations

Urinary 8-oxo-2′-deoxyguanosine — Source, significance and supplements

2000 • 205 citations

Metabolomics in chronic kidney disease

2013 • 202 citations

Susceptibility to Diabetic Nephropathy Is Related to Dicarbonyl and Oxidative Stress

2005 • 190 citations

Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker of Nephropathy in Diabetic Patients

2009 • 186 citations

Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy

2012 • 182 citations

Proteomic analysis for the assessment of diabetic renal damage in humans

2004 • 176 citations

Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

2007 • 165 citations

Markers of Diabetic Nephropathy

1998 • 156 citations

Urinary excretion of 8-oxo-7, 8-dihydro-2′-deoxyguanosine as a predictor of the development of diabetic nephropathy

2002 • 153 citations

Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations

2007 • 152 citations

A genome-wide association study for diabetic nephropathy genes in African Americans

2010 • 146 citations

Urinary Peptidome May Predict Renal Function Decline in Type 1 Diabetes and Microalbuminuria

2009 • 144 citations

Molecular identification of the liver- and the heart-type fatty acid-binding proteins in human and rat kidney. Use of the reverse transcriptase polymerase chain reaction

1992 • 142 citations

A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus

2012 • 136 citations

Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus

2014 • 135 citations

Neutrophil Gelatinase‐Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross‐sectional study and the effects of lisinopril

2010 • 132 citations

Oxidative stress and cellular stress response in diabetic nephropathy

2007 • 132 citations

Vascular endothelial growth factor (VEGF) and soluble VEGF receptor FLT-1 in diabetic nephropathy

2004 • 131 citations

Serum Concentrations of Markers of TNFα and Fas-Mediated Pathways and Renal Function in Nonproteinuric Patients with Type 1 Diabetes

2008 • 128 citations

Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy

2000 • 126 citations

Alpha 1-microglobulin: clinical laboratory aspects and applications

2004 • 124 citations

Genetics of Kidneys in Diabetes (GoKinD) Study

2006 • 123 citations

Urinary tumour necrosis factor- excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients

2006 • 122 citations

Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC–oaTOF-MS system

2009 • 121 citations

Diabetic nephropathy: Traditional to proteomic markers

2013 • 117 citations

Estimated glomerular filtration rate, albuminuria and mortality in type 2 diabetes: the Casale Monferrato study

2007 • 117 citations

Confirmation of Genetic Associations at ELMO1 in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy

2009 • 111 citations

Urinary α1-Microglobulin as a Marker of Nephropathy in Type 2 Diabetic Asian Subjects in Singapore

2003 • 110 citations

Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy

2014 • 110 citations

Inflammation and Insulin Resistance

2003 • 108 citations

Parallel Increase in Urinary Excretion Rates of Immunoglobulin G, Ceruloplasmin, Transferrin, and Orosomucoid in Normoalbuminuric Type 2 Diabetic Patients

2004 • 100 citations

Early Urinary Markers of Diabetic Kidney Disease: A Nested Case-Control Study From the Diabetes Control and Complications Trial (DCCT)

2010 • 100 citations

Plasma Metabolomic Profiles in Different Stages of CKD

2012 • 98 citations

Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy

2011 • 96 citations

Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations

2007 • 94 citations

Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patients

2012 • 93 citations

Defining the Mandate of Proteomics in the Post-Genomics Era: Workshop Report

2002 • 90 citations

Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients

2012 • 86 citations

Progression of microalbuminuria in type 1 diabetes: Ten-year prospective observational study

2005 • 81 citations

Changes of serum and urine neutrophil gelatinase-associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study

2009 • 79 citations

Increased Urinary Levels of Pentosidine, Pyrraline and Acrolein Adduct in Type 2 Diabetes.

2003 • 75 citations

The Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation is less accurate in patients with Type 2 diabetes when compared with healthy individuals

2010 • 75 citations

Tubular and Glomerular Injury in Diabetes and the Impact of ACE Inhibition

2009 • 73 citations

Increased Urinary Excretions of Immunoglobulin G, Ceruloplasmin, and Transferrin Predict Development of Microalbuminuria in Patients With Type 2 Diabetes

2006 • 70 citations

Pentosidine and N-Carboxymethyl-Lysine: Biomarkers for Type 2 Diabetic Retinopathy

2010 • 68 citations

Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration

2011 • 68 citations

Serum cystatin C and urinary enzymes as screening markers of renal dysfunction in diabetic patients.

2005 • 67 citations

Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor- and interleukin-6 in type 2 diabetic patients

2007 • 67 citations

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

2009 • 62 citations

Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease

2011 • 62 citations

Clinical Value of NGAL, L-FABP and Albuminuria in Predicting GFR Decline in Type 2 Diabetes Mellitus Patients

2013 • 59 citations

Genomewide Linkage Scan for Diabetic Renal Failure and Albuminuria: The FIND Study

2011 • 59 citations

Measuring urinary tubular biomarkers in type 2 diabetes does not add prognostic value beyond established risk factors

2012 • 59 citations

Type IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitus

2000 • 58 citations

Plasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitus

2004 • 57 citations

Novel Urinary Protein Biomarkers Predicting the Development of Microalbuminuria and Renal Function Decline in Type 1 Diabetes

2012 • 56 citations

Increased urinary transferrin excretion predicts microalbuminuria in patients with type 2 diabetes.

1999 • 53 citations

Increased Collagen IV Excretion in Diabetes

2001 • 51 citations

Urinary protein excretion in Type 2 diabetes with complications

2000 • 50 citations

Increased urinary excretion of orosomucoid is a risk predictor of diabetic nephropathy

2009 • 50 citations

Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease?

2008 • 49 citations

Increased Vascular Endothelial Growth Factor Serum Concentrations May Help to Identify Patients with Onset of Type 1 Diabetes during Childhood at Risk for Developing Persistent Microalbuminuria

2001 • 48 citations

Microproteinuria in Type 2 Diabetes Mellitus from Diagnosis

1990 • 47 citations

Transferrinuria in type 2 diabetic patients with early nephropathy and tubulointerstitial injury

2002 • 45 citations

Genome‐wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study

2008 • 42 citations

Urinary type IV collagen as a marker for early diabetic nephropathy

1996 • 41 citations

Acute-phase proteins and microalbuminuria among patients with type 2 diabetes

2004 • 39 citations

Serum cystatin C in diabetic patients

2007 • 39 citations

Follow-up study on urinary type IV collagen in patients with early stage diabetic nephropathy

1998 • 35 citations

Association of Plasma Angiotensin-(1–7) Level and Left Ventricular Function in Patients with Type 2 Diabetes Mellitus

2013 • 33 citations

Prospective evaluation of urinary N-acetyl-beta-D-glucosaminidase with respect to macrovascular disease in elderly type 2 diabetic patients.

1999 • 33 citations

Urinary excretion of type IV collagen and laminin in the evaluation of nephropathy in NIDDM: comparison with urinary albumin and markers of tubular dysfunction and/or damage

1995 • 32 citations

Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients

2006 • 31 citations

Should There Be an Expanded Role for Kidney Biopsy in the Management of Patients With Type I Diabetes?

1990 • 29 citations

Genetic Determinants of Diabetic Nephropathy

2003 • 27 citations

Serum cystatin C, enzymuria, tubular proteinuria and early renal insult in type 2 diabetes

2007 • 24 citations

Urinary excretion rate of ceruloplasmin in non-insulin-dependent diabetic patients with different stages of nephropathy

1995 • 21 citations

The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP

2012 • 21 citations

Glycemic Control Reverses Increases in Urinary Excretions of Immunoglobulin G and Ceruloplasmin in Type 2 Diabetic Patients with Normoalbuminuria

2001 • 21 citations

Proteomic Discovery of Diabetic Nephropathy Biomarkers

2010 • 20 citations

Retinopathy in type II diabetes mellitus associated with above-normal urinary excretion of RBP.

1994 • 17 citations

Early renal failure detection by cystatin C in Type 2 diabetes mellitus: varying patterns of renal analyte expression

2009 • 14 citations

<bold>Urinary protein excretion and renal function in young people with diabetes mellitus</bold>

1992 • 12 citations

Proteinuria and enzymuria in non-insulin-dependent diabetics

1993 • 12 citations

Cognitive spatial-motor processes

1991 • 10 citations

Microalbuminuria is closely related to diabetic macroangiopathy

1999 • 9 citations

Can We Use Plasma Fibronectin Levels as a Marker for Early Diabetic Nephropathy.

1995 • 9 citations

Clinical applications of immunoglobulin free light chain estimations

1993 • 9 citations

Do urinary levels of vascular endothelial growth factor predict proliferative retinopathy?

2001 • 5 citations