Gastrointestinal lymphoma: where morphology meets molecular biology

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

2003 • 2,949 citations

Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

1993 • 2,132 citations

Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

1991 • 1,874 citations

Helicobacter pylori Infection and Gastric Lymphoma

1994 • 1,845 citations

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

2000 • 978 citations

Malignant lymphoma of mucosa‐associated lymphoid tissue

1987 • 977 citations

Malignancy in coeliac disease--effect of a gluten free diet.

1989 • 971 citations

Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

1995 • 965 citations

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

1993 • 793 citations

Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma

2000 • 729 citations

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

1999 • 714 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

2003 • 524 citations

Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed

2000 • 505 citations

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

2003 • 498 citations

MALT lymphoma: from morphology to molecules

2004 • 490 citations

Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease

2003 • 449 citations

Eradication of Helicobacter pylori Infection in Primary Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue

1995 • 447 citations

T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

2002 • 414 citations

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

2001 • 409 citations

Primary B-cell gastric lymphoma: A clinicopathological study of 145 patients

1991 • 406 citations

Abnormal intestinal intraepithelial lymphocytes in refractory sprue

1998 • 393 citations

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

1999 • 383 citations

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

2004 • 378 citations

MALIGNANT HISTIOCYTOSIS OF THE INTESTINE: A T-CELL LYMPHOMA

1985 • 362 citations

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

1999 • 354 citations

HELICOBACTER PYLORI-SPECIFIC TUMOUR-INFILTRATING T CELLS PROVIDE CONTACT DEPENDENT HELP FOR THE GROWTH OF MALIGNANT B CELLS IN LOW-GRADE GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE

1996 • 352 citations

Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series

2003 • 343 citations

The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT-) type.

1997 • 343 citations

CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB

2001 • 328 citations

Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma

2003 • 325 citations

Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach.

1990 • 312 citations

Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group

1997 • 305 citations

Intestinal reticulosis as a complication of idiopathic steatorrhoea

1962 • 303 citations

Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment

2001 • 299 citations

NALOXONE AS AN ANTAGONIST IN SEVERE ALCOHOL INTOXICATION

1978 • 296 citations

Mucosal Intra-epithelial Lymphocytes in Enteropathy-Associated T-Cell Lymphoma, Ulcerative Jejunitis, and Refractory Celiac Disease Constitute a Neoplastic Population

1999 • 293 citations

High incidence of primary gastric lymphoma in northeastern Italy

1992 • 289 citations

t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

1997 • 259 citations

Gastric MALT lymphoma: from aetiology to treatment

2002 • 247 citations

Follicular Colonization in B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

1991 • 246 citations

T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10

2001 • 244 citations

Antibiotic Treatment of Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue: An Uncontrolled Trial

1999 • 242 citations

Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori

2001 • 239 citations

Identification of Paracaspases and Metacaspases

2000 • 233 citations

Most CD56+ Intestinal Lymphomas Are CD8+CD5− T-Cell Lymphomas of Monomorphic Small to Medium Size Histology

1998 • 216 citations

Diagnosis and posttreatment follow-up of Helicobacter pylori-positive gastric lymphoma of mucosa-associated lymphoid tissue: histology, polymerase chain reaction, or both?

1996 • 214 citations

Incidence and Subtype Specificity of API2-MALT1 Fusion Translocations in Extranodal, Nodal, and Splenic Marginal Zone Lymphomas

2000 • 211 citations

The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma

1995 • 206 citations

Malignant histiocytosis of the intestine

1978 • 203 citations

Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion.

1996 • 203 citations

The Product of the t(11;18), an API2-MLT Fusion, Marks Nearly Half of Gastric MALT Type Lymphomas without Large Cell Proliferation

2000 • 201 citations

Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation¹

2001 • 195 citations

MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma

2003 • 190 citations

Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways

2002 • 188 citations

Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen.

1995 • 188 citations

BCL10 Expression in Normal and Neoplastic Lymphoid Tissue

2000 • 186 citations

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

2003 • 183 citations

Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction

2001 • 182 citations

Somatic hypermutation in low-grade mucosa-associated lymphoid tissue- type B-cell lymphoma

1995 • 182 citations

Celiac sprue and refractory sprue

1978 • 180 citations

Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy-associated T-cell lymphoma.

1997 • 180 citations

Histological grading in gastric lymphoma: Pretreatment criteria and clinical relevance

1997 • 179 citations

Helicobacter pylori and primary gastric lymphoma

1997 • 174 citations

Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.

1999 • 169 citations

Study of the immunohistochemistry and T cell clonality of enteropathy-associated T cell lymphoma.

1995 • 169 citations

Low‐grade gastric B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT): a multifocal disease

1992 • 163 citations

Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes.

1988 • 152 citations

MALT lymphoma with t(14;18)(q32;q21)/IGH‐MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression

2005 • 148 citations

Chromosomal Gains at 9q Characterize Enteropathy-Type T-Cell Lymphoma

2002 • 143 citations

CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology to Herpesvirus-2 Protein E10

1999 • 142 citations

Clinical and Biochemical Syndrome in Lymphadenoma

1937 • 137 citations

Sp3 and Sp4 Can Repress Transcription by Competing with Sp1 for the Core cis-Elements on the Human ADH5/FDHMinimal Promoter

1999 • 126 citations

The mucosal immune system

2003 • 123 citations

Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma

1996 • 122 citations

Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.

1986 • 122 citations

mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule

1999 • 120 citations

API2-MALT1 Chimeric Transcripts Involved in Mucosa-Associated Lymphoid Tissue Type Lymphoma Predict Heterogeneous Products

2000 • 116 citations

Genetic evidence for a clonal link between low and high‐grade components in gastric MALT B‐cell lymphoma

1997 • 112 citations

CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-κB Activation and Apoptosis

1999 • 111 citations

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

1999 • 110 citations

Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways

2002 • 106 citations

B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis.

1998 • 103 citations

Equine Herpesvirus-2 E10 Gene Product, but Not Its Cellular Homologue, Activates NF-κB Transcription Factor and c-Jun N-terminal Kinase

1999 • 101 citations

Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue.

1997 • 98 citations

Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies.

1997 • 98 citations

Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas

2003 • 97 citations

Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue

2003 • 94 citations

Do vascular addressins mediate tissue specific lymphocyte extravasation?

1988 • 93 citations

Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes

2000 • 93 citations

HLA-DRB, -DQA, and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma

1995 • 93 citations

Distribution of dominant T cell receptor beta chains in human intestinal mucosa.

1994 • 89 citations

Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas

1997 • 86 citations

Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1

2003 • 82 citations

c-E10 Is a Caspase-recruiting Domain-containing Protein That Interacts with Components of Death Receptors Signaling Pathway and Activates Nuclear Factor-κB

1999 • 81 citations

Regulation of lymphocyte traffic by adhesion molecules

1999 • 76 citations

BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression

2002 • 75 citations

Regulatory Mechanisms of TRAF2-mediated Signal Transduction by Bcl10, a MALT Lymphoma-associated Protein

2000 • 75 citations

Detection of immunoglobulin heavy chain gene rearrangement by polymerase chain reaction in chronic active gastritis associated with Helicobacter pylori

1996 • 74 citations

Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease

1990 • 74 citations

Treatment of low grade gastric mucosa-associated lymphoid tissue lymphoma in stage I with Helicobacter pylori eradication. Long-term results after sequential histologic and molecular follow-up.

2001 • 69 citations

Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma

2000 • 65 citations

Helicobacter pylori and the t(11;18)(q21;q21) Translocation in Gastric Low‐grade B‐Cell Lymphoma of Mucosa‐associated Lymphoid Tissue Type

2000 • 65 citations

Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells.

1996 • 65 citations

Preferential Dissemination of B-Cell Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma to the Splenic Marginal Zone

1997 • 64 citations

Relapse of Low-Grade Gastric MALT Lymphoma After Helicobacter Pylori Eradication: True Relapse or Persistence? Long-Term Post-Treatment Follow-Up of a Multicenter Trial in the North-East of Italy and Evaluation of the Diagnostic Protocol’s Adequacy

2000 • 60 citations

Eradication of Helicobacter pylori and Stability of Remissions in Low-Grade Gastric B-Cell Lymphomas of the Mucosa-Associated Lymphoid Tissue: Results of an Ongoing Multicenter Trial

2000 • 60 citations

Heterogeneity in Intraepithelial Lymphocyte Subpopulations in Fetal and Postnatal Human Small Intestine

1989 • 58 citations

Low-Grade Primary B-Cell Lymphoma of the Lung: An Immunohistochemical, Molecular, and Cytogenetic Study of a Single Case

1990 • 58 citations

High Frequency of Genetic Aberrations in Enteropathy-Type T-Cell Lymphoma

2003 • 55 citations

Different bcl-2 protein expression in high-grade B-cell lymphomas derived from lymph node or mucosa-associated lymphoid tissue.

1991 • 55 citations

Primary Non-Hodgkin's Lymphoma of the Intestine: High Prevalence of Epstein-Barr Virus in Mexican Lymphomas as Compared With European Cases

1997 • 54 citations

bcl-6 protein is identified in high-grade but not low-grade mucosa-associated lymphoid tissue lymphomas of the stomach.

1998 • 51 citations

High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation

2002 • 51 citations

Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: Follow-up together with sequential molecular studies

1997 • 49 citations

Loss of heterozygosity at chromosome 9p21 is a frequent finding in enteropathy‐type T‐cell lymphoma

2004 • 47 citations

Epstein‐Barr virus (EBV) in enteropathy‐associated T‐cell lymphoma (EATL)

1993 • 47 citations

Clone-specific PCR reveals wide dissemination of gastric MALT lymphoma to the gastric mucosa

2000 • 46 citations

B-cell clonality and infection with Helicobacter pylori: implications for development of gastric lymphoma.

1996 • 40 citations

The Role of Microsatellite Instability in Gastric Low- and High-Grade Lymphoma Development

2000 • 37 citations

FAS (CD95) Mutations Are Rare in Gastric MALT Lymphoma but Occur More Frequently in Primary Gastric Diffuse Large B-Cell Lymphoma

2004 • 34 citations

High incidence of bcl-6 gene rearrangement in diffuse large b-cell lymphoma of primary gastric origin

1997 • 30 citations

Polymerase chain reaction in the assessment of lymphomas.

1997 • 29 citations

Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections

1996 • 26 citations

When can complete regression of low‐grade gastric lymphoma of mucosa‐associated lymphoid tissue be predicted after Helicobacter pylori eradication?

2000 • 25 citations

Mucosal change of the stomach with low-grade mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow-up study of 48 cases.

2000 • 21 citations

MALT Lymphoma With t(14;18)(q32;q21)/IGH-MALT1 Is Characterized by Strong Cytoplasmic MALT1 and BCL10 Expression

2006 • 19 citations

Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes

2000 • 18 citations

Deleted Work

1955 • 0 citations