Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons

1987 • 902 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions

1984 • 523 citations

Bifunctional messenger RNAs in eukaryotes

1986 • 405 citations

Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1

1987 • 355 citations

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

1989 • 341 citations

Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.

1985 • 329 citations

Latent Herpes Simplex Virus in Human Trigeminal Ganglia

1987 • 328 citations

Detection of herpes simplex virus type 1 transcripts during latent infection in mice

1987 • 300 citations

Herpes simplex virus latency-associated transcript is a stable intron.

1991 • 289 citations

Herpes simplex virus latent phase transcription facilitates in vivo reactivation

1990 • 274 citations

Alternative RNA splicing of the murine αA-crystallin gene: Protein-coding information within an intron

1983 • 251 citations

Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection.

1989 • 246 citations

The functional human dihydrofolate reductase gene.

1984 • 245 citations

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus

1989 • 237 citations

Physical characterization of the herpes simplex virus latency-associated transcript in neurons

1988 • 234 citations

Evidence that Neurons Harbor Latent Herpes Simplex Virus

1974 • 232 citations

Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site.

1986 • 230 citations

Neuron-specific expression of the rat brain type II sodium channel gene is directed by upstream regulatory elements

1990 • 227 citations

HPRT: GENE STRUCTURE, EXPRESSION, AND MUTATION

1985 • 227 citations

Localization of herpes simplex virus in the trigeminal and olfactory systems of the mouse central nervous system during acute and latent infections by in situ hybridization.

1984 • 211 citations

RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.

1987 • 206 citations

Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase

1984 • 203 citations

A herpes simplex virus transcript abundant in latently infected neurons is dispensable for for establishment of the latent state

1988 • 197 citations

Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript

1990 • 188 citations

Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA

1979 • 184 citations

Regulation of Protein Synthesis in Virus-Infected Animal Cells

1986 • 177 citations

The DNA Sequences of the Long Repeat Region and Adjoining Parts of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 172 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames

1988 • 167 citations

Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments.

1980 • 166 citations

Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's

1979 • 155 citations

The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection

1988 • 153 citations

Herpes Simplex Virus Latency: the Cellular Location of Virus in Dorsal Root Ganglia and the Fate of the Infected Cell Following Virus Activation

1980 • 145 citations

Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome

1988 • 140 citations

Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection

1988 • 135 citations

Mobile Introns and Intron-Encoded Proteins

1989 • 134 citations

In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model

1991 • 133 citations

Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1

1990 • 127 citations

Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts

1991 • 118 citations

Prominence of the Herpes Simplex Virus Latency-Associated Transcript in Trigeminal Ganglia from Seropositive Humans

1988 • 112 citations

Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes.

1980 • 112 citations

Latent herpes simplex virus type 1 transcription in human trigeminal ganglia

1988 • 105 citations

Mapping of Low Abundance Latency-associated RNA in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus Type 1

1990 • 103 citations

RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia

1988 • 99 citations

Detection and preliminary characterization of herpes simplex virus type 1 transcripts in latently infected human trigeminal ganglia

1988 • 97 citations

Sequence analysis of adenovirus DNA: Complete nucleotide sequence of the spliced 5′ noncoding region of adenovirus 2 hexon messenger RNA

1979 • 93 citations

A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection

1990 • 87 citations

A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.

1990 • 80 citations

Sequence of the latency-related gene of herpes simplex virus type 1

1989 • 78 citations

Orientation of herpes simplex virus type 1 immediate early mRNA's

1979 • 77 citations

In vitro Promoter Activity Associated with the Latency-associated Transcript Gene of Herpes Simplex Virus Type 1

1989 • 77 citations

Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion

1989 • 70 citations

An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1

1991 • 64 citations

Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes

1988 • 61 citations

The primary structure of the duck alpha D-globin gene: an unusual 5′ splice junction sequence.

1983 • 61 citations

Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase

1985 • 50 citations

A herpes simplex virus type 1 variant, deleted in the promoter region of the latency-associated transcripts, does not produce any detectable minor RNA species during latency in the mouse trigeminal ganglion

1990 • 42 citations

A tandemly reiterated DNA sequence in the long repeat region of herpes simplex virus type 1 found in close proximity to immediate-early mRNA 1

1984 • 41 citations

Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice

1987 • 16 citations