Angiotensin-(1–7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects

A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

2000 • 3,055 citations

A Human Homolog of Angiotensin-converting Enzyme

2000 • 1,970 citations

Angiotensin-converting enzyme 2 is an essential regulator of heart function

2002 • 1,745 citations

Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas

2003 • 1,735 citations

Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

2002 • 1,372 citations

Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors

2004 • 561 citations

Gene Expression in Fibroblasts and Fibrosis

2002 • 508 citations

Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts

1998 • 406 citations

The Cardiac Renin-Angiotensin System

1999 • 395 citations

Angiotensin-(1–7): an update

2000 • 383 citations

Identification of functional angiotensin II receptors on rat cardiac fibroblasts.

1993 • 361 citations

Angiotensin-(1–7) Attenuates the Development of Heart Failure After Myocardial Infarction in Rats

2002 • 323 citations

Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles

2003 • 311 citations

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

2003 • 251 citations

Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.

1994 • 243 citations

Significance of Ventricular Myocytes and Nonmyocytes Interaction During Cardiocyte Hypertrophy

1997 • 238 citations

Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes

2000 • 223 citations

Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.

1997 • 216 citations

Expression of an angiotensin-(1–7)-producing fusion protein produces cardioprotective effects in rats

2004 • 187 citations

Signal transduction mechanisms involved in angiotensin-(1-7)-stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells.

1998 • 178 citations

Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney

2004 • 175 citations

Tumor Necrosis Factor-α–Induced AT ₁ Receptor Upregulation Enhances Angiotensin II–Mediated Cardiac Fibroblast Responses That Favor Fibrosis

2002 • 147 citations

Antiproliferative Actions of Angiotensin-(1-7) in Vascular Smooth Muscle

1999 • 135 citations

Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor

1997 • 135 citations

Cardiac Angiotensin-(1-7) in Ischemic Cardiomyopathy

2003 • 132 citations

Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts

1995 • 103 citations

Tumor Necrosis Factor-α Upregulates Angiotensin II Type 1 Receptors on Cardiac Fibroblasts

1999 • 100 citations

Angiotensin-(1-7) Downregulates the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

2001 • 100 citations

Transcription Factor NF-κB Is Necessary for Up-regulation of Type 1 Angiotensin II Receptor mRNA in Rat Cardiac Fibroblasts Treated with Tumor Necrosis Factor-α or Interleukin-1β

2002 • 80 citations

Cardiac interstitial bradykinin and mast cells modulate pattern of LV remodeling in volume overload in rats

2003 • 42 citations