Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Cancer Cell Cycles

1996 • 5,379 citations

Wnt signalling in stem cells and cancer

2005 • 3,593 citations

Tumour stem cells and drug resistance

2005 • 3,535 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Generation of a functional mammary gland from a single stem cell

2006 • 1,939 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Stem Cells

2000 • 1,783 citations

Applying the principles of stem-cell biology to cancer

2003 • 1,623 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Caught up in a Wnt storm: Wnt signaling in cancer

2003 • 1,473 citations

Cancer Stem Cells: An Old Idea—A Paradigm Shift

2006 • 1,367 citations

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

2003 • 1,303 citations

Tissue repair and stem cell renewal in carcinogenesis

2004 • 1,192 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

2006 • 1,044 citations

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

2006 • 911 citations

Self-renewal and solid tumor stem cells

2004 • 894 citations

Genotype–phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC

2006 • 741 citations

Stem Cells and Cancer

2004 • 739 citations

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16^Ink4a and p19^Arf senescence pathways

2005 • 580 citations

Focus on hepatocellular carcinoma

2004 • 561 citations

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 • 532 citations

Enhanced Self-Renewal of Hematopoietic Stem Cells Mediated by the Polycomb Gene Product Bmi-1

2004 • 517 citations

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

2002 • 463 citations

Bmi1, stem cells, and senescence regulation

2004 • 442 citations

The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis

2005 • 432 citations

Bmi1, stem cells, and senescence regulation

2004 • 411 citations

Cell lineages and oval cell progenitors in rat liver development.

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Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver

2002 • 355 citations

Conditional Deletion of β-Catenin Reveals Its Role in Liver Growth and Regeneration

2006 • 339 citations

Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver

2000 • 293 citations

Hepatocellular Carcinoma: Molecular Pathways and New Therapeutic Targets

2005 • 282 citations

Changes in WNT/β-catenin pathway during regulated growth in rat liver regeneration

2001 • 270 citations

Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes

2002 • 265 citations

Human Umbilical Cord Blood as a Source of Transplantable Hepatic Progenitor Cells

2003 • 241 citations

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

2006 • 223 citations

β-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification

2003 • 216 citations

Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma

2002 • 215 citations

Hepatic ‘stem cell’ malignancies in adults: four cases

2003 • 205 citations

Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity.

1994 • 171 citations

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

2005 • 170 citations

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

2001 • 164 citations

Requirement for Phosphatidylinositol 3-Kinase in Epidermal Growth Factor-Induced AP-1 Transactivation and Transformation in JB6 P⁺ Cells

1996 • 150 citations

Wnt impacts growth and differentiation in ex vivo liver development

2003 • 137 citations

Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach

2004 • 111 citations

Fibroblast Growth Factor Enriches the Embryonic Liver Cultures for Hepatic Progenitors

2004 • 70 citations

Diversity of Hepatic Stem Cells in the Fetal and Adult Liver

2003 • 53 citations

RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA

2004 • 46 citations

Expression of hepatocyte and oval cell antigens in hepatocellular carcinomas produced by oncogene-transfected liver epithelial cells.

1990 • 42 citations